The normal serum cystine aminopeptidase (CAP) range in pregnancy

Chapman, L.; Burrows-Peakin, R.; Jowett, T.P.; Rege, Vaijayanti P.; Silk, E.

doi:10.1016/0009-8981(73)90063-6

Cited by 12 publications

(6 citation statements)

References 5 publications

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“…Serum cystyl aminopeptidase levels increase during normal pregnancy until shortly before the onset of labour (119,176,177). Cystyl aminopeptidase activity in amniotic fluid shows a decrease during pregnancy (53).…”

Section: Cystyl Aminopeptidasementioning

confidence: 99%

Human Aminopeptidases: A Review of the Literature

Sanderink¹,

Artur²,

Siest³

1988

Clinical Chemistry and Laboratory Medicine

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Summary:The aminopeptidases constitute a group of enzymes with closely related activities. In clinical chemistry the analysis of the aminopeptidases and of their multiple forms in serum has for a long time been hindered by considerable confusion concerning their identification, and by a lack of characterization. This is in part due to the often large, and sometimes overlapping substrate specificities of the aminopeptidases. This paper reviews the biochemical properties of the different aminopeptidases, the specificities of the assays used for their analysis in serum, some aspects of their multiple forms -which are especially known to occur for alanine äminopeptidase (EC 3.4.11.2) -and the importance of the determination of aminopeptidases and their multiple forms in clinical chemistry.

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Section: Cystyl Aminopeptidasementioning

confidence: 99%

Human Aminopeptidases: A Review of the Literature

Sanderink¹,

Artur²,

Siest³

1988

Clinical Chemistry and Laboratory Medicine

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“…with cysteineamides was greater than that with the corresponding cystineamides. The increase in the enzyme activity in normal pregnancy, using any of the above substrates, followed the S-shaped curve, which previous workers have described (14,24). The increasing rate and the range of the enzyme activities were different for each substrate used.…”

Section: Discussionmentioning

confidence: 94%

“…5). A similar pattern of enzyme activity was observed in various rat tissues such as liver, brain, heart etc., but in the kidney and small intestine the greatest enzyme activity was obtained with i-cysteine-jS-naphthylamide, followed 14 i 60 "e l 5. with S*benzyl'L-cysteine-p-nitTQ2LW\ide and cystineamides.…”

Section: Correlation Between Cystyl-amino Peptidase Activity and Oestmentioning

confidence: 92%

“…Serum cystyl-amino peptidase (EC 3.4.11.3) catalytic activity is known to increase with advancing gestation, the highest levels being found at term (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). Serial serum cystyl-amino peptidase estimations appear to be helpful in the diagnosis of placental failure (17)(18)(19)(20) and the management of intrauterine fetal growth retardation and fetal distress, etc (21)(22)(23)(24)(25)(26)(27), but there is some controversy (28)(29)(30)(31)(32).…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Substrates for Measuring Cystyl-Amino Peptidase. Activity in Serum of Pregnancy and Hepatic Disease and in Various Tissues

Uete¹,

Motokura²,

Kitano³

et al. 1981

CCLM

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“…Serum CAS levels could be used as a rough guide to birth weight in normotensive mothers but not in mothers with hypertension or pre-eclampsia, which are associated with high CAS levels, although the babies tend to be of low birth weight. Hashimoto (1961) made serial assays of CAS and found that a greater rate of increase was associated with preterm delivery, and maximum and minimum limits for weekly CAS increases have also been laid down (Chapman et al, 1973). By using these, it might be possible to exclude anticipated premature spontaneous deliveries when foretelling the birth weight.…”

Section: Discussionmentioning

confidence: 99%

Serum cystyl aminopeptidase activity in the 36th week of pregnancy.

Durham¹,

Rewell²

1979

J Clin Pathol

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SUMMARY Serum cystyl aminopeptidase (CAS) activity was estimated at 36 weeks' gestation in 209 normotensive pregnancies. The highest activity was found in 31 women who had spontaneous deliveries before 38 weeks' gestation and the lowest in 76 women who were induced after term. The enzyme levels in 117 women who developed hypertension of pregnancy were higher than for normotensives; the highest levels were found in 32 women with pre-eclampsia. A correlation was found between serum CAS activity at 36 weeks' gestation and the birth weight of babies of women who went into spontaneous labour at term (277 to 283 days' gestation).

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The normal serum cystine aminopeptidase (CAP) range in pregnancy

Cited by 12 publications

References 5 publications

Human Aminopeptidases: A Review of the Literature

Human Aminopeptidases: A Review of the Literature

Comparison of Substrates for Measuring Cystyl-Amino Peptidase. Activity in Serum of Pregnancy and Hepatic Disease and in Various Tissues

Serum cystyl aminopeptidase activity in the 36th week of pregnancy.

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