The nonsteroidal anti-inflammatory drug, ibuprofen, affects the immune parameters in the clam Ruditapes philippinarum

NSAID-manufacturing plant effluent induces geno- and cytotoxicity in common carp ( Cyprinus carpio )

“…In contrast, in a study by Matozzo et al (2012), exposure to IBP (100, 500 and 1000 μg L −1 ) did not induce cytotoxicity on hemocytes of R. philippinarum . Tables 3 and 4 show, respectively, the positive correlations observed at certain exposure times between NSAID concentrations and biomarkers of geno-and cytotoxicity (comet assay at 12 h, micronucleus test at 48 and 72 h, caspase-3 activity at 48 h), and among geno-and cytotoxicity biomarkers (comet assay and micronucleus test at 96 h, comet and TUNEL assays at 24 and 48 h, micronucleus test and caspase-3 activity at 24 and 48 h, caspase-3 activity and TUNEL assay at 96 h).…”

“…NSAIDs induce both geno-and cytotoxicity on aquatic organisms such as Oryzias latipes, Dreissena polymorpha, Ruditapes philippinarum and Daphnia magna Hong et al, 2007;Matozzo et al, 2012;Parolini et al, 2010). In addition, pharmaceutical effluents that contain analgesics have been shown to induce genotoxicity in Allium cepa and Swiss mice (Bakare et al, 2009;Oliveira-Júnior et al, 2013).…”

Genotoxic and immunotoxic potential effects of selected psychotropic drugs and antibiotics on blue mussel (Mytilus edulis) hemocytes

“…Mammals receptors may be indeed conserved in invertebrates but not always their specific function, leading to unexpected chronic effects in these organisms (Crane et al, 2006). The effects of pharmaceuticals exposure on freshwater and marine bivalves ranged from the molecular level, such as disturbed enzyme functions, DNA damage, and modulated gene expression (Contardo-Jara et al, 2011;Franzellitti et al, 2013;Gonzalez-Rey and Bebianno, 2013;Parolini et al, 2013;Quinn et al, 2011), to cellular level with increased oxidative stress, cytotoxicity and immunotoxicity (Aguirre-Martínez et al, 2013;Binelli et al, 2009;Canesi et al, 2007;Gagn e et al, 2006a;Gust et al, 2012;MartinDiaz et al, 2009;Matozzo et al, 2012;Munari et al, 2014;Parolini et al, 2011;Tsiaka et al, 2013) to the fitness of organisms with embryotoxicity Hazelton et al, 2013;Di Poi et al, 2014), reprotoxicity (Bringolf et al, 2010;Cortez et al, 2012;Fong and Ford, 2014;Hazelton et al, 2014;Lazzara et al, 2012) and decrease of feeding rate (Sol e et al, 2010). While the effect characterization has already been addressed as one of the big question of pharmaceuticals in the environment (Boxall et al, 2012), their effects on invertebrates remained sometimes controversial.…”

Simulation of a conventional water treatment plant for the minimization of new emerging pollutants in drinking water sources: process optimization using response surface methodology

“…Although, to date, there is no strong evidence regarding the adverse effects of ibuprofen on human health at trace levels, it would be benecial to consider the principle of precaution and make the drinking water free from ibuprofen, thus reducing the potential long term risks. 14 The negative impacts of ibuprofen on the biological systems were well studied and are inevitable. The toxic response of frog embryos towards various doses of ibuprofen using a frog embryo teratogenesis assay-Xenopus (FETAX) has been studied by Richards and Cole.…”