The Noncoding RNA Taurine Upregulated Gene 1 Is Required for Differentiation of the Murine Retina

Young, Tracy L.; Matsuda, Takehisa; Cepko, Constance L.

doi:10.1016/j.cub.2005.02.027

Cited by 445 publications

(364 citation statements)

References 44 publications

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“…This reflected varying roles for TUG1 in different cancer types. Inhibition of IncRNA TUG1 resulted in increased apoptosis in murine retina [21]. In esophageal squamous cell carcinoma, TUG1 promoted proliferation and migration in vitro [18].…”

Section: Discussionmentioning

confidence: 95%

Double‐negative feedback loop between long non‐coding RNA TUG1 and miR‐145 promotes epithelial to mesenchymal transition and radioresistance in human bladder cancer cells

et al. 2015

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a b s t r a c tLncRNAs have a critical role in the regulation of cellular processes such as cancer progression and metastasis. In the present study, we confirmed that TUG1 was overexpressed in bladder cancer tissues and established cell lines. Knockdown of TUG1 inhibited bladder cancer cell metastasis both in vitro and in vivo. Furthermore, we found that TUG1 promoted cancer cell invasion and radioresistance through inducing epithelial-to-mesenchymal transition (EMT). Interestingly, TUG1 decreased the expression of miR-145 and there was a reciprocal repression between TUG1 and miR-145 in an Argonaute2-dependent manner. ZEB2 was identified as a down-stream target of miR-145 and TUG1 exerted its function through the miR-145/ZEB2 axis. In summary, our data indicated that blocking TUG1 function may be an effective anti-cancer therapy.

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Section: Discussionmentioning

confidence: 95%

Double‐negative feedback loop between long non‐coding RNA TUG1 and miR‐145 promotes epithelial to mesenchymal transition and radioresistance in human bladder cancer cells

et al. 2015

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“…lncRNA TUG1 (Taurine Up-regulated Gene 1, TUG1), which is induced by p53, also binds to PRC2, and has a role in repressing specific genes involved in cell-cycle regulation (Khalil et al, 2009). TUG1 was originally identified as a transcript Up-regulated by Taurine, and it was found that knockdown of TUG1 in developing mouse eye blocks retinal development (Young et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

“…LncRNA Taurine Up -regulated Gene 1 (TUG1) was initially identified as a transcript up -regulated by taurine, siRNA -based depletion of TUG1 suppresses mouse retinal development (Young et al, 2005). Previous studies suggest TUG1 can regulate cell cycle by binding to PRC2.…”

Section: Introductionmentioning

confidence: 99%

Down-regulation of Long Non-coding RNA TUG1 Inhibits Osteosarcoma Cell Proliferation and Promotes Apoptosis

Zhang¹,

Geng²,

Yin³

et al. 2013

Asian Pacific Journal of Cancer Prevention

177

137

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Objective: To investigate the expression level of TUG1 and one of its transcript variants (n377360) in osteosarcoma cells and assess the role of TUG1 in proliferation and apoptosis in the U2OS cell line. Methods: TUG1 and n377360 expression levels in patients with osteosarcomas and the U2OS human osteosarcoma cell line were evaluated using real-time quantitative PCR. U2OS cells were transected with TUG1 and n377360 siRNA or non-targeting siRNA. MTS was performed to assess the cell proliferation and flow cytometry was applied to analyze apoptosis. Results: We found significantly higher TUG1 and n377360 expression levels in osteosarcoma tissues compared with matched non-tumorous tissues. In line with this, suppression of TUG1 and n377360 expression by siRNA significantly impaired the cell proliferation potential of osteosarcoma cells. Furthermore, inhibition of TUG1 expression significantly promoted osteosarcoma cell apoptosis. Conclusions: The overexpression of TUG1 and n377360 in osteosarcoma specimens and the functional role of TUG1 and n377360 regarding cell proliferation and apoptosis in an osteosarcoma cell line provided evidence that the use of TUG1 or n377360 may be a viable but an as yet unexplored therapeutic strategy in tumors that over express these factors.

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“…Due to limited read length and computational methods, previous studies did not determine whether these transcripts are spliced. Interestingly, several functionally studied lincRNAs, including Tug1 (Young et al 2005), HOTAIR (Rinn et al 2007), and HOTTIP , are divergent transcripts. We therefore hypothesized that other divergently transcribed transcripts may be spliced and polyadenylated lincRNAs.…”

Section: Divergently Transcribed Lincrnasmentioning

confidence: 99%

Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses

Cabili¹,

Trapnell²,

Goff³

et al. 2011

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Large intergenic noncoding RNAs (lincRNAs) are emerging as key regulators of diverse cellular processes. Determining the function of individual lincRNAs remains a challenge. Recent advances in RNA sequencing (RNA-seq) and computational methods allow for an unprecedented analysis of such transcripts. Here, we present an integrative approach to define a reference catalog of >8000 human lincRNAs. Our catalog unifies previously existing annotation sources with transcripts we assembled from RNA-seq data collected from~4 billion RNA-seq reads across 24 tissues and cell types. We characterize each lincRNA by a panorama of >30 properties, including sequence, structural, transcriptional, and orthology features. We found that lincRNA expression is strikingly tissue-specific compared with coding genes, and that lincRNAs are typically coexpressed with their neighboring genes, albeit to an extent similar to that of pairs of neighboring protein-coding genes. We distinguish an additional subset of transcripts that have high evolutionary conservation but may include short ORFs and may serve as either lincRNAs or small peptides. Our integrated, comprehensive, yet conservative reference catalog of human lincRNAs reveals the global properties of lincRNAs and will facilitate experimental studies and further functional classification of these genes.

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The Noncoding RNA Taurine Upregulated Gene 1 Is Required for Differentiation of the Murine Retina

Abstract: A function for a newly identified ncRNA, TUG1, has been established. TUG1 is necessary for the proper formation of photoreceptors in the developing rodent retina.

Cited by 445 publications

References 44 publications

Double‐negative feedback loop between long non‐coding RNA TUG1 and miR‐145 promotes epithelial to mesenchymal transition and radioresistance in human bladder cancer cells

Double‐negative feedback loop between long non‐coding RNA TUG1 and miR‐145 promotes epithelial to mesenchymal transition and radioresistance in human bladder cancer cells

Down-regulation of Long Non-coding RNA TUG1 Inhibits Osteosarcoma Cell Proliferation and Promotes Apoptosis

Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses

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