“…Presented methods may be useful in many areas of the simulation-based engineering and science, e.g. temperature fields (Styrylska and Pietraszek, 1992) or the statistical estimation of an uncertainty (Pietraszek and Gadek-Moszczak, 2014;Goroshko and Royzman, 2015;Kozien and Kozien, 2017a), especially with non-parametric (Pietraszek et al, 2017a;Pietraszek et al, 2017b) or even fuzzy (Pietraszek and Skrzypczak-Pietraszek, 2014;Pietraszek et al, 2016) approach. Such simulations require systematic approach usually based on the design of experiments methodology (Montgomery, 2008) which is applied widely from biotechnology (Skrzypczak-Pietraszek et al, 2018a;Skrzypczak-Pietraszek et al, 2018b) and phytochemistry (Skrzypczak- Pietraszek and Pietraszek, 2009;Skrzypczak-Pietraszek et al, 2017) through materials science (Scendo et al, 2014;Klimecka-Tatar et al, 2015), the machining (Dwornicka et al, 2017;Radek et al, 2018a;Radek et al, 2018b), the technical stereology (Gadek-Moszczak, 2017;Gadek-Moszczak and Matusiewicz, 2017) up to a large scale research facilities (Baussan et al, 2014;Singh et al, 2016;Singh et al, 2017), a commercialization of scientific research (Kozien and Kozien, 2017b) and a factory lean management (Ulewicz et al, 2013;Ulewicz, 2016;Maszke et al, 2018).…”