The NOD2 receptor modulates the cytokine response but does not alter the clinical outcome of Group B Streptococcus-infected mice
Abstract:The nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is an intracellular receptor capable of sensing bacteria-derived muramyl dipeptide. We investigated the role of NOD2 in the pathogenesis of Group B Streptococcus (GBS) capsular type III, a crucial agent of life-threatening invasive infections, by using an adult NOD2-/-mouse model of infection. We demonstrated that NOD2 is not a key receptor to fight GBS infection and only partially contributes to the inflammatory response. This Research … Show more
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