The NOD/Shi-<i>scid</i>/IL-2Rγ<sup>null</sup>mice xenograft model recapitulates anaplastic large cell lymphoma dissemination to the bladder

Daifu, Tomoo; Umeda, Katsutsugu; Kouzuki, Kagehiro; Hamabata, Takayuki; Noudomi, Seishiro; Saida, Satoshi; Kato, Ikunoshin; Hiramatsu, Hidefumi; Watanabe, Kenichiro; Terada, Naoki; Imamura, Masaaki; Ogawa, Osamu; Heike, Toshio; Adachi, Souichi

doi:10.3109/10428194.2014.966244

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…In all previous reports except one it has been considered a secondary involvement by an advanced stage ALCL (as occurred in our patient). Median age at diagnosis of reported cases was 28‐year‐old, but encompassing a wide range (10‐ to 78‐year‐old) . Most corresponded to male patients (10/12, 83%), as in our case.…”

Section: Discussionsupporting

confidence: 58%

ALK‐negative anaplastic large cell lymphoma with urinary bladder involvement diagnosed in urine cytology: A case report and literature review

Lobo

Henrique

Monteiro

et al. 2017

Diagnostic Cytopathology

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Anaplastic large cell lymphoma is an aggressive T-cell neoplasm. It rarely involves the urinary bladder, with just twelve cases reported thus far and only one being ALK-negative. Immunophenotyping (particularly for ALK) is mandatory, both for prognostic and therapeutic reasons. Herein, we report the case of a patient with an ALK-negative anaplastic large cell lymphoma involving the bladder which was diagnosed and fully characterized by immunocytochemistry in urine cytology. The patient underwent a cystoscopy and the urine sample disclosed tumor diathesis background and aggregates of atypical cells, with evidence of multinucleation and mitotic figures. Immunocytochemistry revealed strong membrane/Golgi positivity for CD30 and negativity for ALK. The patient was submitted to transurethral resection for therapeutic purposes, which confirmed the diagnosis. To the best of our knowledge, this represents only the third case of anaplastic large cell lymphoma with bladder involvement diagnosed in urine cytology and the very first with diagnostic findings allowing for immunophenotyping of the disease in a bladder wash. The present report reinforces the role of urine cytology as a suitable method for establishing an earlier diagnosis and characterization of the disease, avoiding submitting patients to invasive procedures like transurethral resections. Diagn. Cytopathol. 2017;45:354-358. © 2016 Wiley Periodicals, Inc.

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Section: Discussionsupporting

confidence: 58%

ALK‐negative anaplastic large cell lymphoma with urinary bladder involvement diagnosed in urine cytology: A case report and literature review

Lobo

Henrique

Monteiro

et al. 2017

Diagnostic Cytopathology

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Xenograft models for pediatric cancer therapies

McNerney¹,

Teachey²

2021

Fac Rev

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The prognosis for childhood cancer has improved considerably over the past 50 years. This improvement is attributed to well-designed clinical trials which have incorporated chemotherapy, surgery, and radiation. With an increased understanding of cancer biology and genetics, we have entered an era of precision medicine and immunotherapy that provides potential for improved cure rates. However, preclinical evaluation of these therapies is more nuanced, requiring more robust animal models. Evaluation of targeted treatments requires molecularly defined xenograft models that can capture the diversity within pediatric cancer. The development of novel immunotherapies ideally involves the use of animal models that can accurately recapitulate the human immune response. In this review, we provide an overview of xenograft models for childhood cancers, review successful examples of novel therapies translated from xenograft models to the clinic, and describe the modern tools of xenograft biobanks and humanized xenograft models for the study of immunotherapies.

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The NOD/Shi-scid/IL-2Rγ^nullmice xenograft model recapitulates anaplastic large cell lymphoma dissemination to the bladder

Cited by 2 publications

References 9 publications

ALK‐negative anaplastic large cell lymphoma with urinary bladder involvement diagnosed in urine cytology: A case report and literature review

ALK‐negative anaplastic large cell lymphoma with urinary bladder involvement diagnosed in urine cytology: A case report and literature review

Xenograft models for pediatric cancer therapies

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The NOD/Shi-scid/IL-2Rγnullmice xenograft model recapitulates anaplastic large cell lymphoma dissemination to the bladder

Cited by 2 publications

References 9 publications

ALK‐negative anaplastic large cell lymphoma with urinary bladder involvement diagnosed in urine cytology: A case report and literature review

ALK‐negative anaplastic large cell lymphoma with urinary bladder involvement diagnosed in urine cytology: A case report and literature review

Xenograft models for pediatric cancer therapies

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The NOD/Shi-scid/IL-2Rγ^nullmice xenograft model recapitulates anaplastic large cell lymphoma dissemination to the bladder