The NMDA receptor and cocaine: Evidence that MK-801 can induce behavioral sensitization effects

Carey, Robert J.; Dai, Huiliang; Krost, Markus; Huston, Joseph P.

doi:10.1016/0091-3057(95)00074-7

Cited by 44 publications

(16 citation statements)

References 27 publications

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“…Abekawa et al (2007) prenatally treated rats with MK-801; however, it was shown that prenatal exposure to MK-801 neither enhanced the acute eff ects of methamphetamine on postnatal day 35 nor the development of behavioural sensitisation to methamphetamine. Carey et al (1995) found that an NMDA receptor antagonist enhanced behavioural responses evoked by drug stimuli (cocaine) and in this way promoted behavioural sensitisation in rats, which is consistent with our results obtained in the group n 4 where repeated co-administration of methamphetamine + felbamate resulted, after the methamphetamine challenge dose, in the development of behavioural sensitisation to the stimulatory eff ects of methamphetamine.…”

Section: Discussionsupporting

confidence: 82%

The effect of felbamate on behavioural sensitization to methamphetamine in mice

Landa¹,

Šlais²,

Šulcová³

2012

Vet. Med. - Czech

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ABSTRACT:It has been shown that methamphetamine (Met) similary to other psychostimulants induces a progressive augmentation of behavioural responses after repeated administration, so called behavioural sensitisation. Numerous studies refer to an important role for N-methyl-d-aspartate (NMDA) receptors in the development of behavioural sensitisation. Activating antiepileptic drugs of the newer second generation, such as felbamate (Fel), also invoke psychotropic effects. They may possess attention-enhancing and antidepressant activity, causing anxiety, insomnia, and agitation. Although not all pharmacological effects of felbamate are fully elucidated yet, many of its clinical effects may be related to the inhibition of NMDA currents. Thus, the present study was focused on investigating the influence of felbamate on sensitisation to the effects of methamphetamine on mouse locomotor behaviour in the Open field test. Mice of the albino out-bred strain ICR were randomly allocated into four groups and were administered drugs seven times (from the 7 th to 13 th day of the experiment) as follows: (a)

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Section: Discussionsupporting

confidence: 82%

The effect of felbamate on behavioural sensitization to methamphetamine in mice

Landa¹,

Šlais²,

Šulcová³

2012

Vet. Med. - Czech

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“…Our behavioral results also showed a non-significant trend to increase the d-AMPH response 8 days following one injection of MK-801 in the No Stress group. It has been reported that repeated MK-801 treatment increases locomotor activity and can develop sensitization to its own injection (Carey et al, 1995;Segal et al, 1995;Sripada et al, 1998;Vanderschuren et al, 1997;Wolf and Khansa, 1991). However, when MK-801 is coadministered with AMPH, the development of sensitization was blocked suggesting that MK-801 itself produces sensitization through a different mechanism than AMPH (Wolf and Khansa, 1991).…”

Section: Discussionmentioning

confidence: 82%

A Glutamate–Dopamine Interaction in the Persistent Enhanced Response to Amphetamine in Nucleus Accumbens Core but not Shell Following a Single Restraint Stress

Pacchioni

Cador

Bregonzio

et al. 2006

Neuropsychopharmacol

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The administration of psychostimulant drugs or stress can elicit a sensitized response to the stimulating and reinforcing properties of the drug. We previously demonstrated that a single restraint stress session enhanced d-amphetamine (d-AMPH)-induced locomotion the day after the stress session, which lasted up to 8 days. The present experiments were designed to identify the contribution of major dopamine (DA) brain areas in the short-and long-lasting enhancement of d-AMPH-induced locomotion following a single stress, and to test the involvement of N-methyl-D-aspartate (NMDA) receptors in that phenomena. To achieve our goal, 24 h and 8 days after a 2-h restraint stress session either with or without a NMDA receptor blockade, we measured locomotor activity and DA overflow in nucleus accumbens (NAcc) core and shell and caudate putamen (CPu) following a d-AMPH injection (0.5 mg/kg i.p.). The stimulant effect of d-AMPH on DA overflow was enhanced in all nuclei at 24 h after a single stress, while at 8 days the enhanced responsiveness was maintained only in the NAcc core. When the rats were administered with MK-801 (0.1 mg/kg i.p.) 30 min before restraint stress, the d-AMPH-induced enhancement on locomotor activity and DA neurotransmission was prevented in all studied brain areas at both times. These findings show that a glutamate-dopamine link is underlying the short-and long-term d-AMPH-induced enhancement on DA and locomotor activity following stress. The persistent glutamate-dependent DA enhancement in NAcc core highlights the relevance of this region in the long-term proactive effects of stress on vulnerability to drug abuse.

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“…As with PCP, MK801 induces large neuronal vacuoles (Olney's lesions) within 30 min of administration [39]. Furthermore, MK801 paradoxically induces behavioral sensitization and place preference to itself, while blocking the development of these behaviors to other drugs [28,34,[40][41][42][43][44]. Thus, it is difficult to interpret the chronic behavioral effects of co-administering MK801 with psychostimulants as anything other than ambiguous.…”

Section: Introductionmentioning

confidence: 90%

The competitive NMDA receptor antagonist CPP disrupts cocaine-induced conditioned place preference, but spares behavioral sensitization

Carmack

Kim²,

Sage³

et al. 2013

Behavioural Brain Research

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h i g h l i g h t sCPP co-administration with cocaine altered the acute response to cocaine. NMDAR antagonism with CPP had no effect on cocaine-induced behavioral sensitization. NMDAR antagonism with CPP abolished cocaine-induced conditioned place preference. a r t i c l e i n f o a b s t r a c tRecently, the notion that memory and addiction share similar neural substrates has become widely accepted. N-methyl-d-aspartate receptors (NMDAR) are the cornerstones of synaptic models of memory. The present study examined the effect of the competitive NMDAR antagonist CPP on the induction of behavioral sensitization and conditioned place preference to cocaine. Conditioned place preference is an associative memory model of drug seeking, while sensitization is a non-associative model of the transition from casual to compulsive use. There were three principal findings: (1) co-administration of CPP and cocaine altered the acute response to cocaine, suggesting a direct interaction between the two drugs; (2) NMDAR antagonism had no effect on behavioral sensitization; and (3) NMDAR antagonism abolished conditioned place preference. A review of prior evidence supporting a role for NMDARs in sensitization suggests that NMDAR antagonists directly interfere with cocaine's psychostimulant effects, and this interaction could be misinterpreted as a disruption of sensitization. Finally, we suggest that addiction recruits multiple kinds of plasticity, with sensitization recruiting NMDAR-independent mechanisms.

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The NMDA receptor and cocaine: Evidence that MK-801 can induce behavioral sensitization effects

Cited by 44 publications

References 27 publications

The effect of felbamate on behavioural sensitization to methamphetamine in mice

The effect of felbamate on behavioural sensitization to methamphetamine in mice

A Glutamate–Dopamine Interaction in the Persistent Enhanced Response to Amphetamine in Nucleus Accumbens Core but not Shell Following a Single Restraint Stress

The competitive NMDA receptor antagonist CPP disrupts cocaine-induced conditioned place preference, but spares behavioral sensitization

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