The NLRP3 inflammasome: Multiple activation pathways and its role in primary cells during ventricular remodeling

Yan, Zhipeng; Qi, Zhongwen; Yang, Xinggang; Ji, Nan; Wang, Yueyao; Shi, Qi; Li, Meng; Zhang, Junping; Zhu, Yue

doi:10.1002/jcp.30285

Cited by 27 publications

(17 citation statements)

References 154 publications

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“…In addition to cardiovascular diseases such as ischemic heart disease, hypertension, and arrhythmia, inflammation also plays an important role in heart failure ( Pieske et al, 2019 ; Groenewegen et al, 2020 ; Schiattarella et al, 2020 ). Studies have shown that inflammatory factors can lead to ventricular remodeling, which in turn affects the development of heart failure ( Al-Taweel et al, 2017 ; Tan et al, 2021 ; Yan et al, 2021 ). In addition, there are also animal studies and clinical studies focusing on the positive effects of anti-inflammatory treatments on cardiovascular diseases ( Bäck and Hansson, 2015 ; Huang and Frangogiannis, 2018 ; Ma et al, 2019 ; Gao et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Periodontitis Is Associated With Heart Failure: A Population-Based Study (NHANES III)

Yan

Mao

et al. 2022

Front. Physiol.

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Objectives: The aim of this study was to investigate the relationship between periodontitis and heart failure using the Third National Health and Nutrition Examination Survey (NHANES III).Methods: Participants who had received a periodontal examination were included and investigated for the occurrence of heart failure. The included participants were divided into no/mild periodontitis and moderate/severe periodontitis groups according to their periodontal status. Weighted prevalence of heart failure was calculated, and weighted logistic regressions models were used to explore the association between periodontitis and heart failure. Possible influencing factors were then explored through subgroup analysis.Results: Compared with that of the no/mild periodontitis group, the incidence of heart failure in participants with moderate/severe periodontitis was 5.72 times higher (95% CI: 3.76–8.72, p < 0.001). After adjusting for gender, age, race, body mass index, poverty income ratio, education, marital status, smoking status, drinking status, hypertension, diabetes, stroke, and asthma, the results showed that the incidence of heart failure in the moderate/severe group was 3.03 times higher (95% CI: 1.29–7.13, p = 0.012). Subgroup analysis showed that criteria, namely, male, 40–60 years old, non-Hispanic white, body mass index >30, poverty income ratio ≥1, not more than 12 years of education, currently drinking, stroke but no diabetes, or asthma supported moderate/severe periodontitis as a risk factor for heart failure (p < 0.05).Conclusion: According to data from this nationally representative sample from the United States, periodontitis is associated with an increased risk of heart failure.

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Section: Introductionmentioning

confidence: 99%

Periodontitis Is Associated With Heart Failure: A Population-Based Study (NHANES III)

Yan

Mao

et al. 2022

Front. Physiol.

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“…Recent research indicates that activation of the NLRP3 inflammasome has a role in basic structural alterations in VR after AMI [ 40 ]. Cardiac pressure overload causes Ca 2+ influx and triggers the activation of NLRP3 inflammasome in cardiomyocytes, which results in the recruitment of cardiac macrophages, the formation of fibrosis, and the development of myocardial dysfunction [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Exploring the Mechanism of Ling-Gui-Zhu-Gan Decoction in Ventricular Remodeling after Acute Myocardial Infarction Based on UPLC and In Vivo Experiments

Zhou

Zhang

Zhao

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Ventricular remodeling (VR) after acute myocardial infarction (AMI) is an important pathophysiological basis for the development of chronic heart failure (CHF). At present, Ling-Gui-Zhu-Gan decoction (LGZGD) has been widely reported in the clinical treatment and basic research of cardiovascular diseases (CVDs), such as myocardial infarction, heart failure, and angina pectoris. However, the mechanism of LGZGD against VR after AMI remains unclear. Ultra-performance liquid chromatography (UPLC) was applied to investigate the major constituents of LGZGD, and molecular docking was used to predict the targets on the NLRP3/Caspase-1/GSDMD signaling pathway. In vivo, histological changes in the myocardium were visualized using HE staining and Masson staining, and cardiomyocyte apoptosis was detected using TUNEL. IL-1β activity in rat serum was determined by ELISA. Finally, NLRP3, Caspase-1, and GSDMD expressions were analyzed through RT-qPCR and Western blotting. The results showed that 8 authentic reference substances have been detected in LGZGD. Molecular docking showed that the major chemical constituents of LGZGD had a good binding activity with NLRP3, Caspase-1, and GSDMD. Our results showed that LGZGD treatment markedly improved cardiac pathology, decreased cardiomyocyte apoptosis, reduced IL-1β activity, and regulated the expression of genes and proteins related to the NLRP3/Caspase-1/GSDMD signal pathway. These results suggest that LGZGD protects against VR after AMI through NLRP3/Caspase-1/GSDMD signal pathway.

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“…VR is an important factor leading to the poor prognosis of many cardiovascular diseases in the middle and late stages ( 39 ). Therefore, delaying VR is of great significance for improving the quality of life.…”

Section: Discussionmentioning

confidence: 99%

Guanxin V Acts as an Antioxidant in Ventricular Remodeling

Liang

et al. 2022

Front. Cardiovasc. Med.

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Background: Our previous studies have shown that Guanxin V (GXV) is safe and effective in the treatment of ventricular remodeling (VR), but its mechanism related to oxidative stress has not been studied deeply.Methods: We applied integrating virtual screening and network pharmacology strategy to obtain the GXV-, VR-, and oxidative stress-related targets at first, and then highlighted the shared targets. We built the networks and conducted enrichment analysis. Finally, the main results were validated by molecular docking and solid experiments.Results: We obtained 251, 11,425, and 9,727 GXV-, VR-, and oxidative stress-related targets, respectively. GXV-component-target-VR and protein–protein interaction networks showed the potential mechanism of GXV in the treatment of VR. The following enrichment analysis results gathered many biological processes and “two GXV pathways” of oxidative stress-related to VR. All our main results were validated by molecular docking and solid experiments.Conclusion: GXV could be prescribed for VR through the mechanism, including complex interactions between related components and targets, as predicted by virtual screening and network pharmacology and validated by molecular docking and solid experiments. Our study promotes the explanation of the biological mechanism of GXV for VR.

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The NLRP3 inflammasome: Multiple activation pathways and its role in primary cells during ventricular remodeling

Cited by 27 publications

References 154 publications

Periodontitis Is Associated With Heart Failure: A Population-Based Study (NHANES III)

Periodontitis Is Associated With Heart Failure: A Population-Based Study (NHANES III)

Exploring the Mechanism of Ling-Gui-Zhu-Gan Decoction in Ventricular Remodeling after Acute Myocardial Infarction Based on UPLC and In Vivo Experiments

Guanxin V Acts as an Antioxidant in Ventricular Remodeling

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