The Nla28S/Nla28 Two-Component Signal Transduction System Regulates Sporulation in Myxococcus xanthus

Sarwar, Zaara; Garza, Anthony G.

doi:10.1128/jb.00225-12

Cited by 16 publications

(29 citation statements)

References 55 publications

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“…Indeed, the developmental phenotypes of the nla28S mutant are different on media containing different levels of nutrients (67). While no significant defect in aggregation or sporulation efficiency was observed when the ⌬nla28S strain developed on stringent-starvation agar containing no added nutrients, aggregation was delayed and the sporulation efficiency was reduced when the strain was placed on slow-starvation agar containing low levels of essential nutrients.…”

Section: Figmentioning

confidence: 99%

“…Nla6S and Nla28S are predicted to be cytoplasmic and membrane-bound histidine kinase sensors, respectively (28). The signal detected by Nla6S is unknown; however, it has been proposed that the cell density reporter known as A-signal or nutrient levels (starvation) may be the activating signal for Nla28S (67). It is believed that Nla6S modulates the activity of the Nla6 response regulator via dephosphorylation, whereas Nla28S modulates the activity of the Nla28 response regulator via phosphorylation (38,67).…”

Section: Figmentioning

confidence: 99%

“…The signal detected by Nla6S is unknown; however, it has been proposed that the cell density reporter known as A-signal or nutrient levels (starvation) may be the activating signal for Nla28S (67). It is believed that Nla6S modulates the activity of the Nla6 response regulator via dephosphorylation, whereas Nla28S modulates the activity of the Nla28 response regulator via phosphorylation (38,67). Nla6 is a transcriptional activator that regulates genetic loci such as exo, MXAN2688, and MXAN3259 that are important for spore differentiation and spore stress resistance (59).…”

Section: Figmentioning

confidence: 99%

“…However, one candidate is A-signal, which is an early-acting cell density reporter (13,14,16). In particular, expression of nla28S increases when exogenous A-signal is added to A-signal-deficient cells (67) and, since expression of the nla28S-nla28 operon is autoregulated (43), it is possible that Nla28S is involved in the detection of A-signal.…”

Section: Figmentioning

confidence: 99%

“…First, the nla28S and nla28 genes are expressed shortly after starvation initiates development (59,67). Second, a mutation in nla28 starts to affect developmental gene expression patterns 1 h poststarvation (43).…”

Section: Figmentioning

confidence: 99%

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Two-Component Signal Transduction Systems That Regulate the Temporal and Spatial Expression of Myxococcus xanthus Sporulation Genes

Sarwar

Garza

2016

J Bacteriol

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bWhen starved for nutrients, Myxococcus xanthus produces a biofilm that contains a mat of rod-shaped cells, known as peripheral rods, and aerial structures called fruiting bodies, which house thousands of dormant and stress-resistant spherical spores. Because rod-shaped cells differentiate into spherical, stress-resistant spores and spore differentiation occurs only in nascent fruiting bodies, many genes and multiple levels of regulation are required. Over the past 2 decades, many regulators of the temporal and spatial expression of M. xanthus sporulation genes have been uncovered. Of these sporulation gene regulators, twocomponent signal transduction circuits, which typically contain a histidine kinase sensor protein and a transcriptional regulator known as response regulator, are among the best characterized. In this review, we discuss prototypical two-component systems (Nla6S/Nla6 and Nla28S/Nla28) that regulate an early, preaggregation phase of sporulation gene expression during fruiting body development. We also discuss orphan response regulators (ActB and FruA) that regulate a later phase of sporulation gene expression, which begins during the aggregation stage of fruiting body development. In addition, we summarize the research on a complex two-component system (Esp) that is important for the spatial regulation of sporulation.

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Section: Figmentioning

confidence: 99%

Section: Figmentioning

confidence: 99%

Section: Figmentioning

confidence: 99%

Section: Figmentioning

confidence: 99%

Section: Figmentioning

confidence: 99%

See 3 more Smart Citations

Two-Component Signal Transduction Systems That Regulate the Temporal and Spatial Expression of Myxococcus xanthus Sporulation Genes

Sarwar

Garza

2016

J Bacteriol

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Decomposition of aromatic hydrocarbon intermediates by recombinant hydroxyquinol 1,2-dioxygenase from Arthrobacter chlorophenolicus A6 and its structure characterization

Kwon

Suma

Tiwari

et al. 2014

International Biodeterioration & Biodegradation

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The Evolution of Aggregative Multicellularity and Cell–Cell Communication in the Dictyostelia

Kawabe

Schilde

et al. 2015

Journal of Molecular Biology

107

109

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Aggregative multicellularity, resulting in formation of a spore-bearing fruiting body, evolved at least six times independently amongst both eukaryotes and prokaryotes. Amongst eukaryotes, this form of multicellularity is mainly studied in the social amoeba Dictyostelium discoideum. In this review, we summarise trends in the evolution of cell-type specialisation and behavioural complexity in the four major groups of Dictyostelia. We describe the cell–cell communication systems that control the developmental programme of D. discoideum, highlighting the central role of cAMP in the regulation of cell movement and cell differentiation. Comparative genomic studies showed that the proteins involved in cAMP signalling are deeply conserved across Dictyostelia and their unicellular amoebozoan ancestors. Comparative functional analysis revealed that cAMP signalling in D. discoideum originated from a second messenger role in amoebozoan encystation. We highlight some molecular changes in cAMP signalling genes that were responsible for the novel roles of cAMP in multicellular development.

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The Nla28S/Nla28 Two-Component Signal Transduction System Regulates Sporulation in Myxococcus xanthus

Cited by 16 publications

References 55 publications

Two-Component Signal Transduction Systems That Regulate the Temporal and Spatial Expression of Myxococcus xanthus Sporulation Genes

Two-Component Signal Transduction Systems That Regulate the Temporal and Spatial Expression of Myxococcus xanthus Sporulation Genes

Decomposition of aromatic hydrocarbon intermediates by recombinant hydroxyquinol 1,2-dioxygenase from Arthrobacter chlorophenolicus A6 and its structure characterization

The Evolution of Aggregative Multicellularity and Cell–Cell Communication in the Dictyostelia

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