1988
DOI: 10.1016/0169-328x(88)90062-9
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The NGF and kallikrein genes of mouse, the African rat Mastomys natalensis and man: their distribution and mode of expression in the salivary gland

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Cited by 12 publications
(5 citation statements)
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“…Proteolytic cleavage at the C-terminus of p-NGF may be peculiar to 7s complex formation in the mouse salivary glands. Although p-NGF is typically found associated with high molecular weight complexes, the 7s complex has been unequivocally detected only in mouse saliva and salivary glands (Bowcock et al, 1988;Darling and Fahnestock, 1988;Drinkwater et al, 1988;Schwarz et al, 1989). There is no information concerning the exact size of P-NGF (i.e., 118 versus 120 amino acids) synthesized in the CNS.…”
Section: I991mentioning
confidence: 99%
“…Proteolytic cleavage at the C-terminus of p-NGF may be peculiar to 7s complex formation in the mouse salivary glands. Although p-NGF is typically found associated with high molecular weight complexes, the 7s complex has been unequivocally detected only in mouse saliva and salivary glands (Bowcock et al, 1988;Darling and Fahnestock, 1988;Drinkwater et al, 1988;Schwarz et al, 1989). There is no information concerning the exact size of P-NGF (i.e., 118 versus 120 amino acids) synthesized in the CNS.…”
Section: I991mentioning
confidence: 99%
“…Salivary constituents have a number of biological functions, which in some ways are keys to maintaining oral health. Saliva has been recognized as a rich source of growth factors such as epidermal growth factor (EGF) and nerve growth factor (NGF) (2). EGF has hormone‐like properties and consists of 53 amino acids (3).…”
mentioning
confidence: 99%
“…A large family of enzymes with TK-related sequences has been detected in the mouse with as many as 24 to 25 genes, of which 10 to 14 are functional (Mason et al, 1983;Evans et al, 1987;Berg et al, 1992). A similar large number of 11 to 17 genes has been described in the rat (Wines et al, 1991), and in the African rat Mastomys (Bowcock et al, 1988). It has been suggested that these enzymes, differing in substrate specificities, are functionally important because of their ability to selectively cleave very many specific polypeptide precursors of bioactive peptides (Mason et al, 1983;Bothwell et al, 1979).…”
Section: Introductionmentioning
confidence: 84%
“…Large TK multigene families have been identified only in the rat (Wines et al, 1991), mouse (Evans et al, 1987;Berg et al, 1992), and the African rat Mastomys (Bowcock et al, 1988), which are closely related species. Similar multigene families comprising around 10 members have been reported for the trypsins of man (Emi et al, 1986), rat (Craik et al, 1984) and mouse (Stevenson et al, 1986).…”
Section: Discussionmentioning
confidence: 99%