The NF-κB RelA transcription factor is not required for CD8+ T-cell function in acute viral infection and cancer
Allison Voisin,
Maud Plaschka,
Marlène Perrin-Niquet
et al.
Abstract:CD8+ T cells are critical mediators of pathogen clearance and anti-tumor immunity. Although signaling pathways leading to the activation of NF-κB transcription factors have crucial functions in the regulation of immune responses, the CD8+ T cell-autonomous roles of the different NF-κB subunits, are still unresolved. Here, we investigated the function of the ubiquitously expressed transcription factor RelA in CD8+ T-cell biology using a novel mouse model and gene-edited human cells. We found that CD8+ T cell-sp… Show more
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