The NF-κB Nucleolar Stress Response Pathway

Thoms, Hazel C.; Stark, Lesley A.

doi:10.3390/biomedicines9091082

Cited by 10 publications

(9 citation statements)

References 126 publications

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“…Regarding the inflammatory response, numerous studies have been conducted on the role of NF‐κB and its relationship with atherosclerosis; the NF‐κB signaling pathway has been implicated in lipid dysregulation and inflammation [56–57] . NF‐κB, a B‐cell nuclear factor, binds to the immunoglobulin κ site [58] and can specifically bind to the κB site in various promoters. When stimulated by inflammatory factors, activation of the upstream kinase IKK of IκB phosphorylates IκB (P‐IκB) for degradation [59] .…”

Section: Discussionmentioning

confidence: 99%

Butanol Extract of Acanthopanax senticosus (Rupr. et Maxim.) Harms Alleviates Atherosclerosis in Apolipoprotein E‐Deficient Mice Fed a High‐Fat Diet

Jia

Shi

Zhang

et al. 2023

Chemistry & Biodiversity

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This study investigated the effect of butanol extract of AS (ASBUE) on atherosclerosis in apolipoprotein Edeficient (ApoE À /À ) mice. The mice were administered ASBUE (390 or 130 mg/kg/day) or rosuvastatin (RSV) via oral gavage for eight weeks. In ApoE À /À mice, ASBUE suppressed the abnormal body weight gain and improved serum and liver biochemical indicators. ASBUE remarkably reduced the aortic plaque area, improved liver pathological conditions, and lipid metabolism abnormalities, and altered the intestinal microbiota structure in ApoE À /À mice. In the vascular tissue of ASBUE-treated mice, P-IKKβ, P-NFкB, and P-IкBα levels tended to decrease, while IкB-α increased in high fat-diet-fed atherosclerotic mice. These findings demonstrated the antiatherosclerotic potential of ASBUE, which is mediated by the interaction between the gut microbiota and lipid metabolism and regulated via the Nuclear Factor-kappa B (NF-кB) pathway. This work paves the groundwork for subsequent studies to develop innovative drugs to treat atherosclerosis.

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Section: Discussionmentioning

confidence: 99%

Butanol Extract of Acanthopanax senticosus (Rupr. et Maxim.) Harms Alleviates Atherosclerosis in Apolipoprotein E‐Deficient Mice Fed a High‐Fat Diet

Jia

Shi

Zhang

et al. 2023

Chemistry & Biodiversity

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Section: Deregulation Of Ribosome Biogenesis In Cancermentioning

confidence: 99%

“…Therefore, RPs are essential molecules for constructing ribosomal subunits and mature ribosomes. In ribosome biogenesis, TP53, PTEN, and Rb function as potent ribosome biogenesis suppressors [103,104]; conversely, PI3K-Akt-mTOR, c-MYC, RAS-MAPK, and NF-κB function as activators [105][106][107][108][109]. Interestingly, the deregulation of ribosome biogenesis exhibits a paradoxical function from a hypo-proliferative cellular response to a hyper-proliferative oncogenic phenotype, which was referred to as Dameshek's riddle [110].…”

Section: Deregulation Of Ribosome Biogenesis In Cancermentioning

confidence: 99%

Ribosomes and Ribosomal Proteins Promote Plasticity and Stemness Induction in Glioma Cells via Reprogramming

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Shibahara

Inukai

et al. 2022

Cells

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Glioblastoma multiforme (GBM) is a lethal tumor that develops in the adult brain. Despite advances in therapeutic strategies related to surgical resection and chemo-radiotherapy, the overall survival of patients with GBM remains unsatisfactory. Genetic research on mutation, amplification, and deletion in GBM cells is important for understanding the biological aggressiveness, diagnosis, and prognosis of GBM. However, the efficacy of drugs targeting the genetic abnormalities in GBM cells is limited. Investigating special microenvironments that induce chemo-radioresistance in GBM cells is critical to improving the survival and quality of life of patients with GBM. GBM cells acquire and maintain stem-cell-like characteristics via their intrinsic potential and extrinsic factors from their special microenvironments. The acquisition of stem-cell-like phenotypes and aggressiveness may be referred to as a reprogramming of GBM cells. In addition to protein synthesis, deregulation of ribosome biogenesis is linked to several diseases including cancer. Ribosomal proteins possess both tumor-promotive and -suppressive functions as extra-ribosomal functions. Incorporation of ribosomes and overexpression of ribosomal protein S6 reprogram and induce stem-cell-like phenotypes in GBM cells. Herein, we review recent literature and our published data on the acquisition of aggressiveness by GBM and discuss therapeutic options through reprogramming.

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“…Recent studies found that the p53 protein participates in the pathogenesis of podocyte apoptosis (Choy Liang et al, 2021;Yang et al, 2021). As a tumor suppressor, p53 could safeguard the genome and prevent malignant transformation by halting the cell cycle and promoting apoptosis (Jiang et al, 2021;Thoms and Stark, 2021). p53 is increased under stimulation, and then upregulates the expression of pro-apoptotic genes (Eliaš and Macnamara, 2021).…”

Section: P53 Pathwaysmentioning

confidence: 99%

Natural Products Against Renal Fibrosis via Modulation of SUMOylation

et al. 2022

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Renal fibrosis is the common and final pathological process of kidney diseases. As a dynamic and reversible post-translational modification, SUMOylation and deSUMOylation of transcriptional factors and key mediators significantly affect the development of renal fibrosis. Recent advances suggest that SUMOylation functions as the promising intervening target against renal fibrosis, and natural products prevent renal fibrosis via modulating SUMOylation. Here, we introduce the mechanism of SUMOylation in renal fibrosis and therapeutic effects of natural products. This process starts by summarizing the key mediators and enzymes during SUMOylation and deSUMOylation and its regulation role in transcriptional factors and key mediators in renal fibrosis, then linking the mechanism findings of SUMOylation and natural products to develop novel therapeutic candidates for treating renal fibrosis, and concludes by commenting on promising therapeutic targets and candidate natural products in renal fibrosis via modulating SUMOylation, which highlights modulating SUMOylation as a promising strategy for natural products against renal fibrosis.

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The NF-κB Nucleolar Stress Response Pathway

Cited by 10 publications

References 126 publications

Butanol Extract of Acanthopanax senticosus (Rupr. et Maxim.) Harms Alleviates Atherosclerosis in Apolipoprotein E‐Deficient Mice Fed a High‐Fat Diet

Butanol Extract of Acanthopanax senticosus (Rupr. et Maxim.) Harms Alleviates Atherosclerosis in Apolipoprotein E‐Deficient Mice Fed a High‐Fat Diet

Ribosomes and Ribosomal Proteins Promote Plasticity and Stemness Induction in Glioma Cells via Reprogramming

Natural Products Against Renal Fibrosis via Modulation of SUMOylation

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