The NF-κB family member dorsal plays a role in immune response against Gram-positive bacterial infection in mud crab (Scylla paramamosain)

Deng, Hengwei; Hu, Lei; Li, Jingjing; Yan, Wenyan; Song, Enhui; Kuang, Mingqing; Liu, Shanshan; He, Jianguo; Weng, Shaoping

doi:10.1016/j.dci.2019.103581

Cited by 12 publications

(4 citation statements)

References 53 publications

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“…rosenbergii . These findings agreed with those of earlier results (Deng et al., 2020; Li et al., 2019). Previous studies have shown that PI3K is actively involved in the activation of NF‐κB and LPS‐induced signalling (Li, Zhao, et al., 2019).…”

Section: Discussionsupporting

confidence: 94%

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Identifying the function of the PI3K‐AKT pathway during the pathogenic infection of Macrobrachium rosenbergii

Zhan,

Zhou,

Shi

et al. 2023

Journal of Fish Diseases

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The phosphoinositide‐3‐kinase/protein kinase b (PI3K‐Akt) pathway is a signalling pathway based on protein phosphorylation and can be activated by a wide range of factors. To investigate the function of the PI3K‐AKT signalling pathway in antibacterial immunity, we analysed the gene expression level of three key factors (PI3K, AKT and FoxO) and innate immune factors in immune tissues at different time points after Vibrio parahaemolyticus and Staphylococcus aureus infection. Tissues analysis showed that PI3K, AKT, and FoxO were expressed at high levels in the intestinal, hemocytes and hepatopancreas. Moreover, the expression levels of PI3K, AKT and FoxO can be regulated postinfection by different pathogens. In hemocytes and the intestine, V. parahaemolyticus infection was found to regulate the levels of PI3K, AKT, and FoxO more rapidly; however, an S. aureus infection regulated the levels of these factors more rapidly in the hepatopancreas and gills. Analysis showed that V. parahaemolyticus and S. aureus infection caused changes in the gene expression level of crustin, caspase 3 and NF‐κB. Therefore, PI3K‐AKT regulates the downstream immune pathway differentially in different immune tissues and participates in the regulation of cell apoptosis and the inflammatory response by activating caspase and NF‐κB, respectively, following infection with V. parahaemolyticus and S. aureus.

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Section: Discussionsupporting

confidence: 94%

“…In this investigation, we discovered that NF-κB was activated by bacterial infection in the immune tissue of M. rosenbergii. These findings agreed with those of earlier results (Deng et al, 2020;. Previous studies have shown that PI3K is actively involved in the activation of NF-κB and LPSinduced signalling (Li, Zhao, et al, 2019).…”

Section: Discussionsupporting

confidence: 94%

Identifying the function of the PI3K‐AKT pathway during the pathogenic infection of Macrobrachium rosenbergii

Zhan,

Zhou,

Shi

et al. 2023

Journal of Fish Diseases

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“…Dorsal is one of the only two transcription factor members of the NF-κB family of crustaceans and is important for antiviral responses ( 26 , 36 ). In static cells, Dorsal is coupled with Cactus, a homolog of the NF-κB inhibitor IκB, to be retained in the cytoplasm.…”

Section: Discussionmentioning

confidence: 99%

White Spot Syndrome Virus (WSSV) Inhibits Hippo Signaling and Activates Yki To Promote Its Infection in Penaeus vannamei

et al. 2023

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“…Pellino can also interact with Pelle in shrimp. The expression of Pellino is up-regulated upon pathogens stimulation, and to increase the activity of Dorsal, thus enhancing AMPs expression with V. parahaemolyticus challenge ( 85 ), in which Dorsal is also involved in defense against gram-positive bacterial in S. paramamosain ( 90 ). However, the ubiquitinated substrates of Pellino in shrimp (such as whether MyD88 is ubiquitinated) is currently unknown.…”

Section: Ubiquitination In Host-pathogen Interactionsmentioning

confidence: 99%

Ubiquitination as an Important Host-Immune Response Strategy in Penaeid Shrimp: Inferences From Other Species

et al. 2021

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Shrimp aquaculture is an essential economic venture globally, but the industry faces numerous challenges, especially pathogenic infections. As invertebrates, shrimp rely mainly on their innate immune system for protection. An increasing number of studies have shown that ubiquitination plays a vital role in the innate immune response to microbial pathogens. As an important form of posttranslational modification (PTM), both hosts and pathogens have exploited ubiquitination and the ubiquitin system as an immune response strategy to outwit the other. This short review brings together recent findings on ubiquitination and how this PTM plays a critical role in immune modulation in penaeid shrimps. Key findings inferred from other species would help guide further studies on ubiquitination as an immune response strategy in shrimp-pathogen interactions.

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The NF-κB family member dorsal plays a role in immune response against Gram-positive bacterial infection in mud crab (Scylla paramamosain)

Cited by 12 publications

References 53 publications

Identifying the function of the PI3K‐AKT pathway during the pathogenic infection of Macrobrachium rosenbergii

Identifying the function of the PI3K‐AKT pathway during the pathogenic infection of Macrobrachium rosenbergii

White Spot Syndrome Virus (WSSV) Inhibits Hippo Signaling and Activates Yki To Promote Its Infection in Penaeus vannamei

Ubiquitination as an Important Host-Immune Response Strategy in Penaeid Shrimp: Inferences From Other Species

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