The Next Frontier in Neurocritical Care in Resource-Constrained Settings

Raees, Madiha; Cheserem, Beverly; Mutiso, Benjamin; Laeke, Tsegazeab; Brotherton, B. Jason

doi:10.1016/j.ccc.2022.06.016

Cited by 3 publications

(1 citation statement)

References 152 publications

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“…Due to domestic and ambulatory injuries, the prevalence rises after the age of 70. On the other hand, the burden of morbidity and mortality is greatest in the low-income countries, accounting for nearly 90% of the total morbidities and mortalities (Dewan et al 2018 ; Raees et al 2022 ). Nevertheless, traumatic brain injury (TBI) contributes to more than 30% of all injury-related deaths in the USA and represents more than 75,000 deaths each year in Europe (Jullienne et al 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Nervous System Response to Neurotrauma: A Narrative Review of Cerebrovascular and Cellular Changes After Neurotrauma

Ali,

Sula,

AbuHamdia

et al. 2024

J Mol Neurosci

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Neurotrauma is a significant cause of morbidity and mortality worldwide. For instance, traumatic brain injury (TBI) causes more than 30% of all injury-related deaths in the USA annually. The underlying cause and clinical sequela vary among cases. Patients are liable to both acute and chronic changes in the nervous system after such a type of injury. Cerebrovascular disruption has the most common and serious effect in such cases because cerebrovascular autoregulation, which is one of the main determinants of cerebral perfusion pressure, can be effaced in brain injuries even in the absence of evident vascular injury. Disruption of the blood–brain barrier regulatory function may also ensue whether due to direct injury to its structure or metabolic changes. Furthermore, the autonomic nervous system (ANS) can be affected leading to sympathetic hyperactivity in many patients. On a cellular scale, the neuroinflammatory cascade medicated by the glial cells gets triggered in response to TBI. Nevertheless, cellular and molecular reactions involved in cerebrovascular repair are not fully understood yet. Most studies were done on animals with many drawbacks in interpreting results. Therefore, future studies including human subjects are necessarily needed. This review will be of relevance to clinicians and researchers interested in understanding the underlying mechanisms in neurotrauma cases and the development of proper therapies as well as those with a general interest in the neurotrauma field.

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Section: Introductionmentioning

confidence: 99%

Nervous System Response to Neurotrauma: A Narrative Review of Cerebrovascular and Cellular Changes After Neurotrauma

Ali,

Sula,

AbuHamdia

et al. 2024

J Mol Neurosci

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Global neurotrauma: A systematic review and summary of the current state of registries around the world

O’Leary,

Sherwood,

Gundlach

et al. 2024

Journal of Clinical Neuroscience

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The Current Update of Conventional and Innovative Treatment Strategies for Central Nervous System Injury

Tsai,

Wu,

et al. 2024

Biomedicines

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This review explores the complex challenges and advancements in the treatment of traumatic brain injury (TBI) and spinal cord injury (SCI). Traumatic injuries to the central nervous system (CNS) trigger intricate pathophysiological responses, frequently leading to profound and enduring disabilities. This article delves into the dual phases of injury—primary impacts and the subsequent secondary biochemical cascades—that worsen initial damage. Conventional treatments have traditionally prioritized immediate stabilization, surgical interventions, and supportive medical care to manage both the primary and secondary damage associated with central nervous system injuries. We explore current surgical and medical management strategies, emphasizing the crucial role of rehabilitation and the promising potential of stem cell therapies and immune modulation. Advances in stem cell therapy, gene editing, and neuroprosthetics are revolutionizing treatment approaches, providing opportunities not just for recovery but also for the regeneration of impaired neural tissues. This review aims to emphasize emerging therapeutic strategies that hold promise for enhancing outcomes and improving the quality of life for affected individuals worldwide.

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The Next Frontier in Neurocritical Care in Resource-Constrained Settings

Cited by 3 publications

References 152 publications

Nervous System Response to Neurotrauma: A Narrative Review of Cerebrovascular and Cellular Changes After Neurotrauma

Nervous System Response to Neurotrauma: A Narrative Review of Cerebrovascular and Cellular Changes After Neurotrauma

Global neurotrauma: A systematic review and summary of the current state of registries around the world

The Current Update of Conventional and Innovative Treatment Strategies for Central Nervous System Injury

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