The Next Evolution of HemoDialysis eXpanded: From a Delphi Questionnaire-Based Approach to the Real Life of Italian Dialysis Units

Dellepiane, Sergio; Marengo, Marita; D'Arezzo, Mario; Donati, Gabriele; Fabbrini, Paolo; Lacquaniti, Antonio; Ronco, Claudio; Cantaluppi, Vincenzo

doi:10.1159/000522038

Cited by 5 publications

(4 citation statements)

References 57 publications

(69 reference statements)

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“…Validity is related to the purpose of measurement. The same measurement tool has high validity in some measurements, but not in others [ 19 ]. For example, a ruler with high reliability has good validity in measuring height, but not in measuring blood pressure.…”

Section: Methodsmentioning

confidence: 99%

The Acceptability of Traditional Culture under the Background of Deep Learning

Sima

2022

Computational Intelligence and Neuroscience

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The cultural values of a country impact its national psychology and identity. Citizens’ values and public opinions are conveyed to state leaders over the media and other information channels, both directly and indirectly influencing decisions on foreign policy. The traditional cultural values that affect the psyche of the Chinese people are harmony, generosity, morality, courtesy, wisdom, honesty, loyalty, and filial piety. This study aims to analyze the attitudes of Chinese college students toward traditional culture. The reliability and effect factors of the traditional culture acceptability questionnaire are set in the context of deep learning. A questionnaire on traditional culture education of college students is compiled using the indicator evaluation methods, and the current situation of traditional culture education is investigated for college students. A total of 300 valid respondents are returned from five universities including Shanghai Jiaotong University, Fudan University, Yunnan University, Kunming University of Science and Technology, and Yunnan Normal University. Results show that 28% of college students believe that practical activities including visiting and learning and traditional festival commemoration are the most effective ways to educate traditional culture for them, which accounts for the largest percentage. Similarly, 19% of students suggest online publicity, while 16% believe that lecture reports are particularly important, and 12% of students advocate the teaching courses. In addition, about 23% of the students choose other methods, such as seminars, setting up Chinese culture festivals, and building cultural associations. The outcomes of this study provide data support for identifying the shortcomings in traditional cultural education and formulating strategies.

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Section: Methodsmentioning

confidence: 99%

The Acceptability of Traditional Culture under the Background of Deep Learning

Sima

2022

Computational Intelligence and Neuroscience

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“…Hemodiafiltration and medium cut-off (MCO) dialyzers applied to standard hemodialysis, defined as "expanded hemodialysis" (HDx), improved the elimination of middle-to large-sized molecular toxins [103,104], see Figure 1.…”

Section: Uremic Toxin Involvementmentioning

confidence: 99%

Immune System Dysfunction and Inflammation in Hemodialysis Patients: Two Sides of the Same Coin

Campo

Lacquaniti

Trombetta

et al. 2022

JCM

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Biocompatibility in hemodialysis (HD) has considerably improved in recent decades, but remains an open issue to be solved, appearing essential to reduce systemic inflammation and enhance patients’ clinical outcomes. Clotting prevention, reduction in complement and leukocyte activation, and improvement of antioxidant effect represent the main goals. This review aims to analyze the different pathways involved in HD patients, leading to immune system dysfunction and inflammation. In particular, we mostly review the evidence about thrombogenicity, which probably represents the most important characteristic of bio-incompatibility. Platelet activation is one of the first steps occurring in HD patients, determining several events causing chronic sub-clinical inflammation and immune dysfunction involvement. Moreover, oxidative stress processes, resulting from a loss of balance between pro-oxidant factors and antioxidant mechanisms, have been described, highlighting the link with inflammation. We updated both innate and acquired immune system dysfunctions and their close link with uremic toxins occurring in HD patients, with several consequences leading to increased mortality. The elucidation of the role of immune dysfunction and inflammation in HD patients would enhance not only the understanding of disease physiopathology, but also has the potential to provide new insights into the development of therapeutic strategies.

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“…Whereas several studies have assessed the relationship between FLCs and mortality risk in chronic kidney disease (CKD) [ 31 , 32 , 33 ], FLCs received only marginal attention as uremic toxins in non-multiple myeloma HD patients. Lamy evaluated their reduction with different dialyzers, revealing a better removal of κFLCs, but not λFLCs, after hemodiafiltration (HDF) if compared to bicarbonate dialysis [ 34 ]; expanded HD (HDx), based on medium cut-off (MCO) dialyzers, recently demonstrated non-inferiority results about FLC removal, when compared with HDF data [ 35 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

Free Light Chains, High Mobility Group Box 1, and Mortality in Hemodialysis Patients

Lacquaniti

Campo

Falliti

et al. 2022

JCM

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Background: Uremic toxins are associated with immune dysfunction and inflammation. The inadequate removal by hemodialysis (HD) of serum free light chains (FLCs) determines their accumulation. This study evaluated FLCs in HD patients, analyzing their relations with other biomarkers, such as serum high mobility group box 1 (HMGB1). Methods: FLC and HMGB1 were evaluated in a cohort of 119 HD patients. κFLC and λFLC were summated to give a combined (c) FLC concentration. Patients were followed prospectively until the end of the observation period of four years, or until the endpoint: the patient’s death. Results: cFLC values in HD patients were 244.4 (197.9–273.5) mg/L. We detected a significant reduction in CD8+ cells and a decreased CD4+/CD8+ ratio. HMGB1 levels were 94.5 (55–302) pg/mL. After multivariate analysis, cFLCs correlated with β2-microglobulin and the CD4+/CD8+ ratio. Subjects with cFLC values above 263 mg/L and with sHMGB1 values < 80 pg/mL experienced a significantly faster evolution to the endpoint (mean follow-up time to progression of 27.5 and 28.5 months, respectively; p < 0.001). After an adjusted multivariate Cox analysis, cFLCs were associated with 11% increased risk of death, whereas low sHMGB1 increased this risk by 5%. Conclusions: cFLCs and HMGB1 reflect the inflammation and immune dysfunction in HD patients representing two strong and independent risk markers of mortality.

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The Next Evolution of HemoDialysis eXpanded: From a Delphi Questionnaire-Based Approach to the Real Life of Italian Dialysis Units

Cited by 5 publications

References 57 publications

The Acceptability of Traditional Culture under the Background of Deep Learning

The Acceptability of Traditional Culture under the Background of Deep Learning

Immune System Dysfunction and Inflammation in Hemodialysis Patients: Two Sides of the Same Coin

Free Light Chains, High Mobility Group Box 1, and Mortality in Hemodialysis Patients

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