The newly discovered natural compounds against rheumatoid arthritis-an overview

Wang, Xueni; Fang, Gang; Yang, Yang; Pang, Yuzhou

doi:10.1016/j.phytol.2019.09.011

Cited by 14 publications

(9 citation statements)

References 103 publications

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“…As per the WHO, approximately 80% of the global population utilizes indigenous systems of medicine for their primary health care [ 1 ]. Recently, various potential phytocandidates such as β-elemene, brazilin, bufalin, cardamonin, cryptotanshinone, isogarcinol, curcumin, celastrol, lapachol, nobiletin, oroxylin A, thymoquinone, resveratrol, torilin, and swertiamarin have been identified to have pharmacological properties [ 2 ]. Thymoquinone (TQ) is a crucial active ingredient obtained from the black seed of the plant Nigella sativa (NS) and Caramcarvil , with potential antioxidant and anti-inflammatory activities [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Recent Findings on Thymoquinone and Its Applications as a Nanocarrier for the Treatment of Cancer and Rheumatoid Arthritis

et al. 2021

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Cancer causes a considerable amount of mortality in the world, while arthritis is an immunological dysregulation with multifactorial pathogenesis including genetic and environmental defects. Both conditions have inflammation as a part of their pathogenesis. Resistance to anticancer and disease-modifying antirheumatic drugs (DMARDs) happens frequently through the generation of energy-dependent transporters, which lead to the expulsion of cellular drug contents. Thymoquinone (TQ) is a bioactive molecule with anticancer as well as anti-inflammatory activities via the downregulation of several chemokines and cytokines. Nevertheless, the pharmacological importance and therapeutic feasibility of thymoquinone are underutilized due to intrinsic pharmacokinetics, including short half-life, inadequate biological stability, poor aqueous solubility, and low bioavailability. Owing to these pharmacokinetic limitations of TQ, nanoformulations have gained remarkable attention in recent years. Therefore, this compilation intends to critically analyze recent advancements in rheumatoid arthritis and cancer delivery of TQ. This literature search revealed that nanocarriers exhibit potential results in achieving targetability, maximizing drug internalization, as well as enhancing the anti-inflammatory and anticancer efficacy of TQ. Additionally, TQ-NPs (thymoquinone nanoparticles) as a therapeutic payload modulated autophagy as well as enhanced the potential of other drugs when given in combination. Moreover, nanoformulations improved pharmacokinetics, drug deposition, using EPR (enhanced permeability and retention) and receptor-mediated delivery, and enhanced anti-inflammatory and anticancer properties. TQ’s potential to reduce metal toxicity, its clinical trials and patents have also been discussed.

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Section: Introductionmentioning

confidence: 99%

Recent Findings on Thymoquinone and Its Applications as a Nanocarrier for the Treatment of Cancer and Rheumatoid Arthritis

et al. 2021

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“…In addition to acting as a protective mechanism against ROS, antioxidants could suppress the expression of the cytokines and collagenase induced by TNF‐α, which is also a protective mechanism against arthritis (Halliwell et al., 1988; Sato et al., 1996). It is hypothesized that natural compounds with antioxidant properties may exert protective effects against RA (Bae et al., 2003; Wang et al., 2019). Propolis is a natural compound that is expected to be effective in reducing oxidative stress levels (Abass et al., 2017; Mujica et al., 2017; Pahlavani et al., 2020).…”

Section: Methodsmentioning

confidence: 99%

Does propolis have any effect on rheumatoid arthritis? A review study

Nattagh‐Eshtivani

Pahlavani

Ranjbar

et al. 2022

Food Science & Nutrition

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Rheumatoid arthritis (RA) is a chronic autoimmune disease in which inflammation and oxidative stress play a key role in its pathophysiology. Complementary therapies along with medications may be effective in the control of RA. Propolis is a natural substance extracted from beehives, which have confirmed anti‐inflammatory and antioxidant effects. The present study aimed to review the possible effects of propolis on inflammation, oxidative stress, and lipid profile in patients with RA. English articles in online databases such as PubMed‑Medline, AMED, Google Scholar, EMBASE, Scopus, and Web of Science databases were searched. Pieces of evidence show that supplementation with propolis may have therapeutic effects on RA patients. Due to increased inflammation and oxidative stress in the affected joints of RA patients, propolis could inhibit the inflammatory cascades by inhibiting the nuclear factor kappa B pathway and reducing reactive oxygen species, malondialdehyde, and interleukin‐17 by increasing some antioxidants. Therefore, inflammation and pain reduce, helping improve and control RA in patients. Further investigations are required with larger sample sizes and different doses of propolis to demonstrate the definite effects of propolis on various aspects of RA.

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“…Since synthetic drugs have the highest possibility of adverse events, nowadays, natural/herbal drugs are more prominent. Some of the natural molecules possessing anti-rheumatic activity are brazilin, βelemene, cardamonin, bufalin, celastrol, curcumin, isogarcinol, etc [7]. The reason for the impairment of joint is due to the multifaceted interaction of the immune modulators.…”

Section: Fig 1 Stages Of Rheumatoid Arthritismentioning

confidence: 99%

A Comprehensive Review on Rheumatoid Arthritis

Nithyashree

Deveswaran

2020

JPRI

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Rheumatoid arthritis is an enduring inflammatory disease that is categorized by bumping off the joint and rigidity, bone and cartilage devastation all above the joints. It is an autoimmune disease or disease caused by factors like smoking, obesity, etc. Cytokines are the main inducers for rheumatoid arthritis which produce interleukin 1β and interleukin 6 factors that cause the devastation of synovium and cartilage present at the joints. The deformation of skeletal muscles is observed in an arthritic patient. The present review is a discussion on rheumatoid arthritis that includes etiology, pathology and pathogenesis, signs and symptoms, clinical complications, diagnosis, treatment, therapy, certain patents and applications. The patents include the development of numerous novel techniques for the management of rheumatoid arthritis and diseases associated with rheumatoid arthritis. The targets to treat rheumatoid arthritis are interleukins, tumor necrosis factor-alpha, sialoprotein I and several other factors. Different biomarkers are used for different types of rheumatoid arthritis and the mechanism also varies. Certain marketed formulations were enlisted. Recent trends in the management of rheumatoid arthritis are the main concern of this article.

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The newly discovered natural compounds against rheumatoid arthritis-an overview

Cited by 14 publications

References 103 publications

Recent Findings on Thymoquinone and Its Applications as a Nanocarrier for the Treatment of Cancer and Rheumatoid Arthritis

Recent Findings on Thymoquinone and Its Applications as a Nanocarrier for the Treatment of Cancer and Rheumatoid Arthritis

Does propolis have any effect on rheumatoid arthritis? A review study

A Comprehensive Review on Rheumatoid Arthritis

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