The new Y Chromosome Haplotype Reference Database

Willuweit, Sascha; Roewer, Lutz

doi:10.1016/j.fsigen.2014.11.024

Cited by 193 publications

(117 citation statements)

References 21 publications

Supporting

Mentioning

113

Contrasting

Unclassified

Order By: Relevance

“…No exact match with the King's STR haplotype was found in the current databases (Willuweit and Roewer 2015;Fatolitis and Ballantyne 2008). The closest haplotype to that of King Béla III was found in the YHRD and showed a one-repeat difference in marker DYS389II.…”

Section: Discussionmentioning

confidence: 87%

DNA profiling of Hungarian King Béla III and other skeletal remains originating from the Royal Basilica of Székesfehérvár

Olasz

Seidenberg²,

Hummel³

et al. 2018

Archaeol Anthropol Sci

View full text Add to dashboard Cite

A few decades after the collapse of the Avar Khaganate (c. 822 AD), Hungarian invaders conquered the Carpathian Basin (c. 862-895 AD). The first Hungarian ruling dynasty, the Árpáds played an important role in European history during the Middle Ages. King Béla III (1172-1196) was one of the most significant rulers of the dynasty. He also consolidated Hungarian dominance over the Northern Balkans. The provostry church of the Virgin Mary (commonly known as the Royal Basilica of Székesfehérvár) played a prominent role as a coronation church and burial place of medieval Hungarian kings. The basilica's building and graves had been destroyed over the centuries. The only royal graves that remained intact were those of King Béla III and his first spouse, Anna of Antioch. These graves were discovered in 1848. We defined the autosomal STR (short tandem repeat) fingerprints of the royal couple and eight additional individuals (two females and six males) found in the Royal Basilica. These results revealed no evidence of first-degree relationship between any of the investigated individuals. Y-chromosomal STR profiles were also established for all the male skeletons. Based upon the Y-chromosomal data, one male skeleton showed an obvious patrilineal relationship to King Béla III. A database search uncovered an existing Y-chromosomal haplotype, which had a single-repeat difference compared to that of King Béla. It was discovered in a person living in an area close to Hungary. This current male line is probably related paternally to the Árpád Dynasty. The control region of the mitochondrial DNA was determined in the royal couple and in the remains of the inferred relative. The mitochondrial results excluded sibling relationship between the King and the patrilineal relative. In summary, we successfully defined a Y-chromosomal profile of King Béla III, which can serve as a reference for the identification of further remains and disputed living descendants of the Árpád Dynasty. Among the examined skeletons, we discovered an Árpád member, whose exact affiliation, however, has not yet been established.

show abstract

Section: Discussionmentioning

confidence: 87%

DNA profiling of Hungarian King Béla III and other skeletal remains originating from the Royal Basilica of Székesfehérvár

Olasz

Seidenberg²,

Hummel³

et al. 2018

Archaeol Anthropol Sci

View full text Add to dashboard Cite

show abstract

“…To assess the information value of the 133 complete Y-STR profiles (116 PowerPlex Y23, 17 Yfiler profiles), all haplotypes were searched against the YHRD database [20], release 49, February 2015. Of these haplotypes, 93% (124/133) did not match a reference sample.…”

Section: Resultsmentioning

confidence: 99%

Validation of a combined autosomal/Y-chromosomal STR approach for analyzing typical biological stains in sexual-assault cases

Purps

Geppert

Nagy

et al. 2015

Forensic Science International: Genetics

Self Cite

View full text Add to dashboard Cite

DNA testing is an established part of the investigation and prosecution of sexual assault. The primary purpose of DNA evidence is to identify a suspect and/or to demonstrate sexual contact. However, due to highly uneven proportions of female and male DNA in typical stains, routine autosomal analysis often fails to detect the DNA of the assailant. To evaluate the forensic efficiency of the combined application of autosomal and Y-chromosomal short tandem repeat (STR) markers, we present a large retrospective casework study of probative evidence collected in sexual-assault cases. We investigated up to 39 STR markers by testing combinations of the 16-locus NGMSElect kit with both the 23-locus PowerPlex Y23 and the 17-locus Yfiler kit. Using this dual approach we analyzed DNA extracts from 2077 biological stains collected in 287 cases over 30 months. To assess the outcome of the combined approach in comparison to stand-alone autosomal analysis we evaluated informative DNA profiles. Our investigation revealed that Y-STR analysis added up to 21% additional, highly informative (complete, single-source) profiles to the set of reportable autosomal STR profiles for typical stains collected in sexual-assault cases. Detection of multiple male contributors was approximately three times more likely with Y-chromosomal profiling than with autosomal STR profiling. In summary, 1/10 cases would have remained inconclusive (and could have been dismissed) if Y-STR analysis had been omitted from DNA profiling in sexual-assault cases.

show abstract

“…QC tools were put in place in conjunction with databasing efforts (EMPOP at http://empop.online [16] and YHRD at http://yhrd.org [17]) to avoid the publication of erroneous data [16,18,19]. The editors of the leading forensic genetic journals; Forensic Science International: Genetics [20] and International Journal of Legal Medicine [21] require QC of mtDNA and Y-STR population data prior to submission of the research papers to the journals.…”

Section: Status Quo Of Autosomal Str Quality Control and Databasingmentioning

confidence: 99%

Recommendations of the DNA Commission of the International Society for Forensic Genetics (ISFG) on quality control of autosomal Short Tandem Repeat allele frequency databasing (STRidER)

Bodner

Bastisch

Butler

et al. 2016

Forensic Science International: Genetics

145

View full text Add to dashboard Cite

The new Y Chromosome Haplotype Reference Database

Cited by 193 publications

References 21 publications

DNA profiling of Hungarian King Béla III and other skeletal remains originating from the Royal Basilica of Székesfehérvár

DNA profiling of Hungarian King Béla III and other skeletal remains originating from the Royal Basilica of Székesfehérvár

Validation of a combined autosomal/Y-chromosomal STR approach for analyzing typical biological stains in sexual-assault cases

Recommendations of the DNA Commission of the International Society for Forensic Genetics (ISFG) on quality control of autosomal Short Tandem Repeat allele frequency databasing (STRidER)

Contact Info

Product

Resources

About