The new two-component conformity index formula (TCCI) and dose-volume comparisons of the pituitary gland and tonsil cancer IMRT plans using a linear accelerator and helical Tomotherapy

Piotrowski, Tomasz; Martenka, Piotr; Patoul, N. De; Jodda, A.; Coevoet, M.; Malicki, Julian; Vynckier, Stefaan

doi:10.1016/s1507-1367(10)60028-4

Cited by 15 publications

(12 citation statements)

References 27 publications

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“…1 Many indices are available to measure dose conformity and uniformity. 2,3 However, because of variations within the tumour structure, some regions respond differently to radiation. A prime example of this involves hypoxic regions within the tumour, which have been found to have a negative impact on the response to radiotherapy [4][5][6][7] and have been associated with radioresistance.…”

Section: Introductionmentioning

confidence: 99%

Comparison of treatment planning parameters for dose painting head and neck plans delivered with tomotherapy

Skórska

Piotrowski

Ryczkowski

et al. 2016

BJR

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Objective: The aim of this study was to determine which physical delivery parameter changes are most suitable for multiple-level dose-painting treatment plans with helical tomotherapy (HT). Methods: A total of 96 treatment plans were generated for 12 patients who had undergone fluorine-18 fludeoxyglucose positron emission tomography/CT ( 18 F-FDG-PET/CT) scan to plan head and neck cancer treatment. Based on these PET-CT images, the dose was escalated to 96 Gy in 32 fractions as a function of PET intensity values. The intensity-based prescription was converted into seven discrete dose levels. For the same patient, different HT plans were optimized by varying parameters such as field width (FW), pitch (PF) and modulation factor (MF). Dose conformity was evaluated using quality-volume histograms, quality factors (QFs), weighted index of achievement (IOA w ), coldness (IOC w ) and hotness (IOH w ). Moreover, doses to organs at risk (OARs), target volumes and execution time were analyzed. Results: Median QFs were the best for FW 5 1.05 cm (QF 5 2.10) and the worst for FW 5 2.5 cm (QF 5 3.04). The same trend was observed for IOA w , IOC w and IOH w . Combination of FW 5 1.05 cm and MF 5 5 leads to the longest beam-on time (above 25 min), whereas FW 5 2.5 cm and MF 5 3 lead to the shortest time (below 8 min). Data analyzed based on dose-volume histogram showed that changes in FW had the strongest impact on plan quality, whereas the effect of MF and PF changes was moderate. Conclusion: HT is suitable for multiple-level dose-painting treatment plans. Advances in knowledge: Changes in FW and MF had the greatest impact on dose distribution quality and beam-on time. Changes in PF only influenced doses to the OARs.

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Section: Introductionmentioning

confidence: 99%

Comparison of treatment planning parameters for dose painting head and neck plans delivered with tomotherapy

Skórska

Piotrowski

Ryczkowski

et al. 2016

BJR

Self Cite

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“…were specified in the literature to distinguish between plans. 11,12 The formulas of the indices mentioned before, are based mainly on simple rates of selected dosimetric parameters for target volume and healthy tissue. More appropriate analysis of dose distribution, which takes into account complex shape of the DVH curves and the priority of each structure, is very often impossible with available indices.…”

Section: Introductionmentioning

confidence: 99%

Comparison of dose distribution in IMRT and RapidArc technique in prostate radiotherapy

Leszczyński¹,

Ślosarek²,

Szlag³

2012

Reports of Practical Oncology & Radiotherapy

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“…IMRT, in contrast, although more complex2,13,16,34, allows for more homogenous dose deposition in the target while sparing surrounding normal tissues. Moreover, IMRT allows for integration of the boost dose (SIB) in one course of the treatment, thus resulting in a higher fraction dose (hypofractionation, i.e.…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, IMRT has become the primary treatment technique in H&N cancers due to its better dose conformity, demonstrated very well in the treatment of lesions with complex anatomy which are adjacent to vital structures such as the spinal cord or brain stem 7,9–11. However, this improved the conformity to the target which may have an undesirable drawback as the large number of fields used in IMRT can potentially lead to higher doses outside the planning treatment volume (PTV) 9,12,13. IMRT also requires more complex quality assurance procedures 2,14–17…”

Section: Introductionmentioning

confidence: 99%

Doses in organs at risk during head and neck radiotherapy using IMRT and 3D-CRT

Peszyńska-Piorun¹,

Malicki²

2012

Radiology and Oncology

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Background.Treatment planning for head and neck (H&N) cancer is complex due to the number of organs at risk (OAR) located near the planning treatment volume (PTV). Distant OAR must also be taken into consideration. Intensity-modulated radiotherapy (IMRT) and three-dimensional conformal radiotherapy (3D-CRT) are both common H&N treatment techniques with very different planning approaches. Although IMRT allows a better dose conformity in PTV, there is much less evidence as to which technique less dose to OAR is delivered. Therefore, the aim of the study was to compare IMRT to 3D-CRT treatment in terms of dose distribution to OAR in H&N cancer.Patients and methods.This was a prospective study of a series of 25 patients diagnosed with stage cT3–4N0–2 laryngeal cancer. All patients underwent total laryngectomy and bilateral selective neck dissections. In all cases, patients were treated with IMRT, although a 3D-CRT treatment plan was also developed for the comparative analysis. To compare doses to specific OAR, we developed a new comparative index based on sub-volumes.Results.In general, IMRT appears to deliver comparable or greater doses to OAR, although the only significant differences were found in the cerebellum, in which 3D-CRT was found to better spare the organ.Conclusions.Organs located outside of the IMRT beam (i.e., distant organs) are generally thought to be well-spared. However, the results of this study show that, in the case of the cerebellum, this was not true. This finding suggests that larger studies should be performed to understand the effects of IMRT on distant tissues. Anthropomorphic phantom studies could also confirm these results.

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The new two-component conformity index formula (TCCI) and dose-volume comparisons of the pituitary gland and tonsil cancer IMRT plans using a linear accelerator and helical Tomotherapy

Cited by 15 publications

References 27 publications

Comparison of treatment planning parameters for dose painting head and neck plans delivered with tomotherapy

Comparison of treatment planning parameters for dose painting head and neck plans delivered with tomotherapy

Comparison of dose distribution in IMRT and RapidArc technique in prostate radiotherapy

Doses in organs at risk during head and neck radiotherapy using IMRT and 3D-CRT

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