The new quinazoline derivative (N-methyl-N-[(thiophen-2-yl)methyl]quinazoline-2,4-diamine) vasodilates isolated mesenteric arteries through endothelium-independent mechanisms and has acute hypotensive effects in Wistar rats

Chatturong, Usana; Chootip, Krongkarn; Martin, Hélène; Tournier-Nappey, Maude; Ingkaninan, Kornkanok; Temkitthawon, Prapapan; Sermsenaphorn, Saharat; Somarin, Thanachon; Konsue, Adchatawut; Gleeson, M. Paul; Totoson, Perle; Demougeot, Céline

doi:10.1016/j.ejphar.2023.175829

Cited by 2 publications

(1 citation statement)

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“… 3 Also, imide derivatives at 0.5 kg/ha preemergent gave slight (10–30%) control of weeds. 4 On the other hand, quinazoline derivatives cause vasodilation in animals, 5 , 6 and in vivo, testing showed that this in vitro activity translated to animal models predictive of chronic diseases such as depression and inflammation. 7 , 8 As well as, several advanced malignant bacterial forms have emerged because inappropriate antibiotic use in one patient can result in the establishment of a resistant strain that spreads to other people, each with varying levels of resistance to a therapeutic agent.…”

Section: Introductionmentioning

confidence: 99%

Powerful Approach for New Drugs as Antibacterial Agents via Molecular Docking and In Vitro Studies of Some New Cyclic Imides and Quinazoline-2,5-diones

Nasser Binjawhar,

Abu Ali,

Alqahtani

et al. 2024

ACS Omega

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We generated novel elven 1,2,3,6-tetrahydrophthalimides and tetrahydroquinazoline derivatives from 1,2,3,6-tetrahydrophthalic anhydride (1) in response to our interest in using the anhydrides to produce heterocyclic nitrogen compounds. The elemental and spectral analyses of the produced compounds validated the recommended configurations and MOE 2014.09 (Molecular Operating Environment) computations were used to perform their in silico analysis. The synthesized compounds have been analyzed and put through various experiments, including in vitro and in silico methods to assess their biological activity against Escherichia coli Penicillin-Binding Protein 3 (PBP3) and Staphylococcus aureus Penicillin-Binding Protein 2 (PBP2), among these compounds showing promising data as antibacterial drugs.

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Section: Introductionmentioning

confidence: 99%

Powerful Approach for New Drugs as Antibacterial Agents via Molecular Docking and In Vitro Studies of Some New Cyclic Imides and Quinazoline-2,5-diones

Nasser Binjawhar,

Abu Ali,

Alqahtani

et al. 2024

ACS Omega

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Biological activities of recent advances in quinazoline

Gamal Al-Kaf,

Abdullah Al-Robaidi

2024

Recent Advances on Quinazoline

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Quinazolines are important stable heterocyclic compounds of great biological activates. Naturally, they are found in many plants that are the source of these quinazolines in addition they are synthesized chemically. Recently quinazolines represent a nucleus of the vast majority of novel compounds that have promising biological activity. They show different activities by acting on different body targets such activities are anticancer, antihypertensive, antimicrobial, antifungal, antibacterial, analgesic, anti-inflammatory, antituberculosis, and antimalarial activity. This chapter highlights the recent advance in the biological activates of quinazolines and quinazolines derivatives on different biological targets.

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The new quinazoline derivative (N-methyl-N-[(thiophen-2-yl)methyl]quinazoline-2,4-diamine) vasodilates isolated mesenteric arteries through endothelium-independent mechanisms and has acute hypotensive effects in Wistar rats

Cited by 2 publications

References 36 publications

Powerful Approach for New Drugs as Antibacterial Agents via Molecular Docking and In Vitro Studies of Some New Cyclic Imides and Quinazoline-2,5-diones

Powerful Approach for New Drugs as Antibacterial Agents via Molecular Docking and In Vitro Studies of Some New Cyclic Imides and Quinazoline-2,5-diones

Biological activities of recent advances in quinazoline

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