Abstract:N 6 -methyladenosine (m 6 A) is the most prevalent internal RNA post-transcriptional modification in eukaryotes. This type of modification is dynamically reversible and epigenetically regulated by a collaborative interplay of methyltransferases, demethylases, and m 6 A-binding proteins. Modification of m 6 A plays a critical role in post-transcriptional regulation of gene expression, involving various processes in RNA metabolism, such as RNA processing, nuclear export, and translation, thereby participating in… Show more
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