The new mycobacteria: an update

Tortoli, Enrico

doi:10.1111/j.1574-695x.2006.00123.x

Cited by 130 publications

(96 citation statements)

References 58 publications

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“…Fanti et al (2004), Floyd et al (1996Floyd et al ( , 2000, Haas et al (1997), Karassova et al (1965), Levi et al (2003), Meier et al (1993), Pourahmad et al (2008), Selvarangan et al (2004), Springer et al (1993Springer et al ( , 1996b, Torkko et al (2002), Tortoli (2003Tortoli ( , 2006, Tortoli et al (1996aTortoli et al ( , b, 1997Tortoli et al ( , 2002Tortoli et al ( , 2005a, Turenne et al (2004a, b) …”

Section: E Tortoli and Othersmentioning

confidence: 99%

Mycobacterium europaeum sp. nov., a scotochromogenic species related to the Mycobacterium simiae complex

Tortoli

Böttger

Fabio

et al. 2011

International Journal of Systematic and Evolutionary Microbiology

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Mycobacterium europaeum sp. nov., a scotochromogenic species related to the Mycobacterium simiae complex Four strains isolated in the last 15 years were revealed to be identical in their 16S rRNA gene sequences to MCRO19, the sequence of which was deposited in GenBank in 1995. In a polyphasic analysis including phenotypic and genotypic features, the five strains (including MCRO19), which had been isolated in four European countries, turned out to represent a unique taxonomic entity. They are scotochromogenic slow growers and are genetically related to the group that included Mycobacterium simiae and 15 other species. The novel species Mycobacterium europaeum sp. nov. is proposed to accommodate these five strains. Strain FI-95228 T (5DSM 45397 T 5CCUG 58464 T ) was chosen as the type strain. In addition, a thorough revision of the phenotypic and genotypic characters of the species related to M. simiae was conducted which leads us to suggest the denomination of the 'Mycobacterium simiae complex' for this group.A unique genetic signature characterizes a limited number of slowly growing non-tuberculous mycobacteria; it is represented by a 12 nt deletion in the 16S rRNA gene starting at Escherichia coli position 459. About 20 years ago, when genetic sequencing of the 16S rRNA gene began to be used for the taxonomic characterization of mycobacteria, Mycobacterium simiae appeared to be the only slowly growing mycobacterial species presenting the aforesaid deletion (Rogall et al., 1990; Kirschner et al., 1993b). Mycobacterium interjectum (Springer et al., 1993) was the first species to be newly described that was recognized to share this genetic marker with M. simiae and, in subsequent years, the group of M. simiae-like organisms has steadily extended and includes 16 species at present (Böttger et al., 1993;Fanti et al., 2004;Floyd et al., 1996Floyd et al., , 2000Haas et al., 1997;Karassova et al., 1965;Levi et al., 2003;Meier et al., 1993; Pourahmad et al., 2008;Selvarangan et al., 2004;Springer et al., 1993Springer et al., , 1996b

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Section: E Tortoli and Othersmentioning

confidence: 99%

Mycobacterium europaeum sp. nov., a scotochromogenic species related to the Mycobacterium simiae complex

Tortoli

Böttger

Fabio

et al. 2011

International Journal of Systematic and Evolutionary Microbiology

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“…The organism is aerobic, and growth occurs at 30°C to 37°C on Lowenstein-Jensen and MacConkey agars without crystal violet but not on 5% NaCl LJ medium. Isolates exhibit arylsulfatase activity at 3 days, low level of heat-stable catalase, and hydrolysis in Tween 80 but no nitrate reductase activity (2,6).…”

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confidence: 99%

First Report of Mycobacterium canariasense Catheter-Related Bacteremia in the Americas

et al. 2014

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e Mycobacterium canariasense is a recently described late-pigmenting, rapidly growing mycobacterium linked to bacteremia in patients with underlying malignant diseases. We report a case of M. canariasense infection in a patient from Massachusetts with underlying diffuse B cell lymphoma, which was identified both by multilocus sequence typing and matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS). To our knowledge, this is the first description after its original identification in Spain and the first report of this opportunistic pathogen in the Americas. CASE REPORT We report a case of catheter-related bacteremia by Mycobacterium canariasense in a 42-year-old patient from Massachusetts with a history of intravenous drug abuse, hepatitis C, and diffuse B cell lymphoma.The patient presented complaining of fever (101.2°F), chills, vomiting, and nausea since 2 days prior to his admission. Six weeks earlier, he had been admitted and diagnosed with presumptive osteomyelitis of the sacroiliac joint for which he received empirical treatment with intravenous vancomycin for 6 weeks, completed a week prior to admission. Multiple sets of blood cultures were negative during this admission. At that time, a bone marrow biopsy was also performed for pancytopenia, and the patient was diagnosed with diffuse large B cell lymphoma with plasmacytoid features. He received two cycles of antineoplastic chemotherapy with cyclophosphamide, doxorubicin hydrochloride, vincristine, and prednisolone (R-CHOP), with the second cycle administered 2 days prior to admission and coinciding with the onset of fever.He did not report rashes, headache, cough, or gastrointestinal complaints, and his prior medical history was significant for bipolar and major depressive disorder as well as essential hypertension. Liver function tests were monitored for hepatitis C exacerbation but were within reference limits. A complete blood count was notable for total leukocytes of 5,150/mm 3 , with 50.5% neutrophils and 16.8% lymphocytes, decreased hemoglobin of 8.6 g/dl, hematocrit of 31.2%, and a normal platelet count of 381,000/mm 3 . Blood urea nitrogen, serum creatinine, and glucose were within reference ranges.Shortly after admission during a febrile episode, blood cultures were drawn and the peripherally inserted central catheter was removed and sent for culture using the roll-plate semiquantitative technique described by Maki et al. (1). The blood cultures in the aerobic bottles grew Candida dubliniensis, Candida albicans, Pseudomonas aeruginosa, and numerous Gram-variable rods. Candida species were determined with both the API 20C AUX and matrixassisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) systems. The catheter tip grew numerous Gram-variable rods as well as a group B beta-streptococcus.The Gram-variable rods (which grew from 4/4 bottles collected in two sets 3 days apart) grew on Lowenstein-Jensen (LJ) medium after 4 days (at 37°C) and revealed small, smooth, nonpigmented coloni...

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“…In fact, roughly 20% (n=16) of the pulmonary infections were caused by members of the M. simiae complex and among these, 14 belonged to an unidentified taxon (n=14 (Tortoli, 2003(Tortoli, , 2006Tortoli et al, 2010). However, among these species, only M. simiae is recognized as a real cause of pulmonary infections, as reported in areas such as the Southwest of the United States, Israel and Cuba .…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Nontuberculous Mycobacterial Infections in the State of Para, an Endemic Region for Tuberculosis in North of Brazil

Costa¹,

Lopes²,

Sousa³

et al. 2012

Pulmonary Infection

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The new mycobacteria: an update

Cited by 130 publications

References 58 publications

Mycobacterium europaeum sp. nov., a scotochromogenic species related to the Mycobacterium simiae complex

Mycobacterium europaeum sp. nov., a scotochromogenic species related to the Mycobacterium simiae complex

First Report of Mycobacterium canariasense Catheter-Related Bacteremia in the Americas

Pulmonary Nontuberculous Mycobacterial Infections in the State of Para, an Endemic Region for Tuberculosis in North of Brazil

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