The New Histologic Classification of Lung Primary Adenocarcinoma Subtypes Is a Reliable Prognostic Marker and Identifies Tumors With Different Mutation Status

Lupo, Audrey; Bobbio, Antonio; Blons, Hélène; Becht, Étienne; Ouakrim, Hanane; Didelot, Audrey; Charpentier, Marie-Christine; Bain, Serge; Marmey, B; Bonjour, Patricia; Biton, Jérôme; Cremer, Isabelle; Dieu-Nosjean, Marie-Caroline; Sautès-Fridman, Catheriné; Régnard, Jean-François; Laurent‐Puig, Pierre; Alifano, Marco; Damotte, Diane

doi:10.1378/chest.13-2499

Cited by 83 publications

(69 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a series of 407 adenocarcinomas from France [21], high stage had adverse survival impact, as did high grade (mostly solid adenocarcinoma). In a study of 904 patients published by TSUTA et al [14], stage was of critical importance and 5-and 10-year overall survival followed the predominant histology; this group also shows a contribution of lymphovascular invasion to adverse prognosis of T1 patients.…”

Section: Prognosis Across All Stagesmentioning

confidence: 99%

Prognostic considerations of the new World Health Organization classification of lung adenocarcinoma

Borczuk

2016

Eur Respir Rev

View full text Add to dashboard Cite

The 2015 World Health Organization (WHO) lung adenocarcinoma classification divides tumours into categories of indolent pre-invasive, minimally invasive and predominantly lepidic and, by examining predominant patterns of invasion, allows for further stratification into intermediate and highgrade tumours. The impact of the 2015 classification on prognosis was reviewed by a PubMed search for search terms "adenocarcinoma", "lung pathology" and "prognosis" and relevant publications reviewed. These were sorted for data on stage and survival as impacted by histological classification, and survival studies were separated into all stage versus stage 1 studies. Predictive aspects of histological classification were also examined, but molecular correlates were not. The separation of adenocarcinoma in situ and minimally invasive adenocarcinoma from invasive subtypes as distinct prognostic entities and the prognostic significance, for disease specific and overall survival for low-and high-grade categories, are discussed. The impact on stage at presentation including risk of node metastasis by histology is examined, as well as histology in relation to recurrence after surgery. Early data with regard to the value of predominant histology in the prediction of chemotherapy response will also be explored. @ERSpublications Lepidic lung ADC often early stage and indolent; solid and micropapillary tumours often metastatic and recurrent http://ow.ly/DCiT305xExK

show abstract

Section: Prognosis Across All Stagesmentioning

confidence: 99%

Prognostic considerations of the new World Health Organization classification of lung adenocarcinoma

Borczuk

2016

Eur Respir Rev

View full text Add to dashboard Cite

show abstract

“…6 Additionally, prognostic signifi cance of histologic subtypes-based on the 2011 International Association for the Study of Lung Cancer, American Th oracic Society, and European Respiratory Society (IASLC/ATS/ERS) lung adenocarcinoma classifi cation system 7 -has been validated in large, independent cohorts spanning multiple countries. [8][9][10][11][12] A limitation of the IASLC/ATS/ERS classifi cation is that the majority ( . 40%) of adenocarcinoma cases are classified as intermediate-grade, acinar or papillary subtype, and these patients also displayed a wide spectrum of clinical outcomes.…”

Section: [ 1 4 8 # 3 C H E S T S E P T E M B E R 2 0 1 5 ]mentioning

confidence: 99%

“…40%) of adenocarcinoma cases are classified as intermediate-grade, acinar or papillary subtype, and these patients also displayed a wide spectrum of clinical outcomes. [8][9][10][11][12] Th us, it would be helpful to identify significant prognostic factors that can further stratify patients within the intermediate-grade group. In this study, we investigated whether tumor budding can predict patient disease recurrence and can be used to further stratify patients with histologically intermediate-grade tumors into prognostic subgroups.…”

Section: [ 1 4 8 # 3 C H E S T S E P T E M B E R 2 0 1 5 ]mentioning

confidence: 99%

Tumor Budding Correlates With the Protumor Immune Microenvironment and Is an Independent Prognostic Factor for Recurrence of Stage I Lung Adenocarcinoma

Kadota

Yeh

Villena-Vargas

et al. 2015

CHEST

View full text Add to dashboard Cite

show abstract

“…The International Society for the Study of Lung Cancer (IASLC), the American Thoracic Society and the European Respiratory Society jointly published a histological classification of lung adenocarcinomas in 2011 (3). The main interest of such classification is its prognostic value, since histological type is closely associated with clinical, pathological and molecular parameters (4,5).…”

Section: Introductionmentioning

confidence: 99%

Primary mucinous adenocarcinoma of the lung: A case report and review of the literature

et al. 2017

View full text Add to dashboard Cite

Abstract. Mucinous adenocarcinoma is an unusual histological type of lung cancer, and its clinicopathological feature is distinctive from that of other histopathological types of lung adenocarcinoma. Mucinous adenocarcinoma has a mucus-producing function, which explains its name. The present study reports a rare case of a mucus-producing adenocarcinoma of the lung. A 60-year-old Chinese female patient was diagnosed with mucinous adenocarcinoma of the lung, which manifested as respiratory symptoms, including fever, cough and expectoration. The patient received thoracic exploratory operation and right pneumonectomy, since the above respiratory symptoms seriously affected her daily life, and other inspections could not establish the diagnosis. Histopathology revealed no mutations in epidermal growth factor receptor. The patient received adjuvant chemotherapy using taxol and cisplatin. However, metastases in the left lung were detected 7 months after the operation. Pemetrexed and cisplatin were used as the second-line treatment. The patient survived 3 years after the initial diagnosis. The present study reports a rare mucus-producing adenocarcinoma of the lung, which is of bad prognosis. Therefore, further studies on this type of cancer are urgently required. IntroductionLung cancer is the leading cancer in terms of mortality and morbidity in the world, and adenocarcinomas are common histological types of lung cancer (1,2). The International Society for the Study of Lung Cancer (IASLC), the American Thoracic Society and the European Respiratory Society jointly published a histological classification of lung adenocarcinomas in 2011 (3). The main interest of such classification is its prognostic value, since histological type is closely associated with clinical, pathological and molecular parameters (4,5).Mucinous adenocarcinoma is the rarest type of lung adenocarcinoma (6). According to a recent classification (3), mucinous adenocarcinoma includes mucinous adenocarcinoma in situ, minimally invasive adenocarcinoma and invasive mucinous adenocarcinoma. These tumors tend to present KRAS mutations and commonly lack thyroid transcription factor-1 expression, and computed tomography (CT) usually indicates nodules of consolidation with air bronchograms that are generally multinodular and multilobular in distribution (5). Mucinous adenocarcinoma of the lung is morphologically characterized by tall columnar cells with abundant cytoplasm that contain varying amounts of mucin (6,7). Mucus secreted by cancer cells can commonly be discharged as sputum. However, if airway obstruction happens, obstructive pneumonia occurs immediately, since the mucus fails to drain (8-10). Case reportThe patient was a 60-year-old female. On October 2011, the patient developed fever, with a temperature fluctuation between 37.5 and 39.0˚C, in addition to cough and yellow sputum, but no chills or shivering, abdominal pain or diarrhea, sore throat, urinary frequency or urgency, or dysuria. In the Hospital of Traditional Chinese Medicine, a CT scan of t...

show abstract

The New Histologic Classification of Lung Primary Adenocarcinoma Subtypes Is a Reliable Prognostic Marker and Identifies Tumors With Different Mutation Status

Cited by 83 publications

References 36 publications

Prognostic considerations of the new World Health Organization classification of lung adenocarcinoma

Prognostic considerations of the new World Health Organization classification of lung adenocarcinoma

Tumor Budding Correlates With the Protumor Immune Microenvironment and Is an Independent Prognostic Factor for Recurrence of Stage I Lung Adenocarcinoma

Primary mucinous adenocarcinoma of the lung: A case report and review of the literature

Contact Info

Product

Resources

About