The new era in the pharmacological treatment of overactive bladder (OAB): mirabegron – a new selective β3agonist

The actions of neurotensin in rat bladder detrusor contractility

“…Conservative treatment options for OAB include lifestyle modification, pelvic floor exercises and medication. Although many researches have focused on the use of anticholinergic medications to treat OAB, the effectiveness is still not satisfactory 28 . Anticholinergics are considered to be the most effective drugs at present.…”

Can botox improve night‐time overactive bladder symptoms in women?

“…The first‐line pharmacotherapy for OAB starts with antimuscarinics or mirabegron . These oral therapies are not sufficiently effective for many patients.…”

“…14,15 The first-line pharmacotherapy for OAB starts with antimuscarinics or mirabegron. 16,17 These oral therapies are not sufficiently effective for many patients. Antimuscarinics can be useful in OAB with nocturia; however, their effectiveness in reduction of nocturia episodes may be still not sufficient enough in many patients.…”

Incidence of Ambulatory Care Visits and Association with Comorbidities of Overactive Bladder in Taiwan

“…The 2014 survey in Taiwan also revealed that 35% of Taiwanese women were aware of their OAB symptoms. OAB symptoms often negatively affect the social life, work, mood, family life, and sex life of patients and thus seriously affect their quality of life [18,19,[22][23][24][25][26][27][28][29][30].…”

“…With the effects of OAB symptoms on their careers, the daily work of 24.9% of male patients is affected and job decisions for 10% of male patients are underdetermined and thus prompt them to change jobs or become dismissed; early retirement is documented in 7.8% of male patients; female patients also experience similar cases [6,28].…”