The New Changes of Epidemiology, Etiology, and Clinical Characteristics of Pyogenic Liver Abscesses: A Retrospective Study in a Hospital in Northern China

JinHua, Cui; Liu, YaMan; Li, Jian

doi:10.2147/idr.s416860

Cited by 3 publications

(2 citation statements)

References 39 publications

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“…The results demonstrated that patients with GFPLA had worse liver function, more severe in ammatory responses, and a higher in-hospital mortality rate than patients with non-GFPLA, in line with previous studies indicating that GFPLA has more severe clinical characteristics [6, 8, [22][23][24]. Investigations of risk factors associated with GFPLA can help clarify the underlying pathological mechanisms of the greater disease severity in patients with GFPLA.…”

Section: Discussionsupporting

confidence: 87%

Gas Formation in Pyogenic Liver Abscess Is Independently Correlated with Diabetes Mellitus but not with Pathogenic Bacteria

Guo,

Wang,

Gong

et al. 2024

Preprint

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Background Gas formation is a typical imaging feature of pyogenic liver abscess (PLA). However, the underlying mechanism of gas formation and its impact on the clinical characteristics of PLA remains unclear. The current study investigated the clinical characteristics of gas-forming PLA (GFPLA) and explored risk factors for GFPLA from both the host and pathogenic bacterium perspectives. Results The GFPLA group exhibited greater disease severity and a higher in-hospital mortality rate. The proportions of patients with diabetes mellitus (DM, P < 0.001) and biliary abnormality (P = 0.001) were higher in the GFPLA group. DM was an independent risk factor for GFPLA, whereas the time from symptom onset to CT and positivity for Klebsiella pneumoniae and Escherichia coli were not independent risk factors for GFPLA. 16S rDNA sequencing revealed no significant differences in bacterial community richness, diversity, evenness, and composition between the groups(P all > 0.05). In vitro fermentation experiments illustrated that high glucose levels was associated with greater gas production by both Klebsiella pneumoniae and Escherichia coli than low glucose levels (both P < 0.01). Conclusion GFPLA was associated with more severe disease and greater in-hospital mortality than non-GFPLA. Gas formation in PLA might be related to high blood glucose levels, but not to pathogenic bacteria composition.

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Section: Discussionsupporting

confidence: 87%

Gas Formation in Pyogenic Liver Abscess Is Independently Correlated with Diabetes Mellitus but not with Pathogenic Bacteria

Guo,

Wang,

Gong

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…However, if the infection is not effectively managed, it can progress to disseminated infection, sepsis, and potentially death, especially in individuals with type 2 diabetes mellitus (T2DM). 5,7,8 PLA patients with DM tend to experience more severe symptoms compared to PLA patients without DM. 9,10 Over 140 million Chinese adults were estimated to have diabetes in 2021, and this number is projected to increase to over 174 million by 2045.…”

Section: Introductionmentioning

confidence: 99%

Alterations of Gut Microbiota in Pyogenic Liver Abscess Patients with and without Type 2 Diabetes Mellitus

Liu,

Ge,

et al. 2024

IDR

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The clinical manifestations of pyogenic liver abscess (PLA) vary between patients with and without diabetes mellitus (DM). However, the relationship between PLA and the gut microbiome remains unknown. This study analyzed the composition of gut microbiota in PLA patients with and without DM and healthy controls (HCs) with the goal of identifying potential reasons for the observed variations in clinical manifestations. Patients and Methods: Using 16S ribosomal RNA(16S rRNA) gene sequencing, we analyzed the compositions of gut microbiota in 32 PLA patients with DM, 32 PLA patients without DM, and 29 matched HCs. Results: In PLA patients with DM, the D-dimer level, fibrinogen degradation products, and thrombin time were significantly higher compared to the PLA patients without DM (P < 0.05). The abundance and diversity of intestinal flora were reduced in both groups of PLA patients compared with the HCs (P < 0.05). Specifically, the PLA patients with DM showed significant decreases in the relative abundances of Bacteroides, Blautia, Prevotella9, and Faecalibacterium, whereas Enterococcus and Escherichia-Shigella were relatively more abundant (P < 0.05). Compared to PLA patients without DM, those with DM had lower relative abundances of Lactobacillus and Klebsiella (P < 0.05) and showed different bacterial flora, including Anaerosporobacter and Megamonas. Conclusion: PLA patients with DM exhibited more severe clinical manifestations of PLA compared to patients without DM. It is important to monitor blood coagulation in PLA patients with DM to prevent the development of thrombotic diseases. Additionally, PLA patients with DM exhibit distinct differences in the composition and diversity of their intestinal flora compared to both PLA patients without DM and HCs.

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Iron regulatory protein 2 contributes to antimicrobial immunity by preserving lysosomal function in macrophages

Cheng,

Xing,

Zhang

et al. 2024

Proc. Natl. Acad. Sci. U.S.A.

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Colorectal cancer and Crohn’s disease patients develop pyogenic liver abscesses due to failures of immune cells to fight off bacterial infections. Here, we show that mice lacking iron regulatory protein 2 ( Irp2 ), globally ( Irp2 −/− ) or myeloid cell lineage ( Lysozyme 2 promoter-driven, LysM )-specifically ( Irp2 ΔLysM ) , are highly susceptible to liver abscesses when the intestinal tissue was injured with dextran sodium sulfate treatment. Further studies demonstrated that Irp2 is required for lysosomal acidification and biogenesis, both of which are crucial for bacterial clearance. In Irp2 -deficient liver tissue or macrophages, the nuclear location of transcription factor EB (Tfeb) was remarkably reduced, leading to the downregulation of Tfeb target genes that encode critical components for lysosomal biogenesis. Tfeb mislocalization was reversed by hypoxia-inducible factor 2 inhibitor PT2385 and, independently, through inhibition of lactic acid production. These experimental findings were confirmed clinically in patients with Crohn’s disease and through bioinformatic searches in databases from Crohn’s disease or ulcerative colitis biopsies showing loss of IRP2 and transcription factor EB (TFEB)-dependent lysosomal gene expression. Overall, our study highlights a mechanism whereby Irp2 supports nuclear translocation of Tfeb and lysosomal function, preserving macrophage antimicrobial activity and protecting the liver against invading bacteria during intestinal inflammation.

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The New Changes of Epidemiology, Etiology, and Clinical Characteristics of Pyogenic Liver Abscesses: A Retrospective Study in a Hospital in Northern China

Cited by 3 publications

References 39 publications

Gas Formation in Pyogenic Liver Abscess Is Independently Correlated with Diabetes Mellitus but not with Pathogenic Bacteria

Gas Formation in Pyogenic Liver Abscess Is Independently Correlated with Diabetes Mellitus but not with Pathogenic Bacteria

Alterations of Gut Microbiota in Pyogenic Liver Abscess Patients with and without Type 2 Diabetes Mellitus

Iron regulatory protein 2 contributes to antimicrobial immunity by preserving lysosomal function in macrophages

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