The new age of insecticide discovery-the crop protection industry and the impact of natural products

Sparks, Thomas C.; Wessels, Frank J.; Lorsbach, Beth A.; Nugent, Benjamin M.; Watson, Gerald B.

doi:10.1016/j.pestbp.2019.09.002

Cited by 97 publications

(130 citation statements)

References 36 publications

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“…For instance, between 1981 and 2014 over 50% of newly developed drugs were developed from NPs [1]. NPs and their derivatives are also actively studied in food [4][5][6][7][8], cosmetic industries [9,10] and in agriculture, with natural pesticides development [11]. This growing interest over NPs and their application resolved in uncontrollable growth of the number of published open and commercial databases, industrial catalogues, books of NPs and collections of structures provided in supplementary materials or research articles, compiling NPs from various organisms, geographical locations, targeted diseases and traditional uses.…”

Section: Introductionmentioning

confidence: 99%

Review on natural products databases: where to find data in 2020

2020

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Natural products (NPs) have been the centre of attention of the scientific community in the last decencies and the interest around them continues to grow incessantly. As a consequence, in the last 20 years, there was a rapid multiplication of various databases and collections as generalistic or thematic resources for NP information. In this review, we establish a complete overview of these resources, and the numbers are overwhelming: over 120 different NP databases and collections were published and re-used since 2000. 98 of them are still somehow accessible and only 50 are open access. The latter include not only databases but also big collections of NPs published as supplementary material in scientific publications and collections that were backed up in the ZINC database for commercially-available compounds. Some databases, even published relatively recently are already not accessible anymore, which leads to a dramatic loss of data on NPs. The data sources are presented in this manuscript, together with the comparison of the content of open ones. With this review, we also compiled the open-access natural compounds in one single dataset a COlleCtion of Open NatUral producTs (COCONUT), which is available on Zenodo and contains structures and sparse annotations for over 400,000 non-redundant NPs, which makes it the biggest open collection of NPs available to this date.

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Section: Introductionmentioning

confidence: 99%

Review on natural products databases: where to find data in 2020

2020

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“…There has been a greater emphasis and expanded use during the past 25 years of narrower spectrum insecticides such as the neonicotinoids and tetramic acid insecticides for sucking insect pests, and diamides and spinosyns for chewing insect pests such as lepidopterans. 16,17 This situation provides the opportunity to conceive of and patent potential mixtures of insecticides to address the needs for controlling broad complexes of sap-feeding and chewing (e.g. lepidopteran) insect pests.…”

Section: Trendsmentioning

confidence: 99%

“…This interest in mixtures is potentially associated, at least in part, with a decline in the use and sales of broad‐spectrum insecticides such as organophosphates and carbamates, due to a variety of factors including resistance in pest insects and environmental concerns. There has been a greater emphasis and expanded use during the past 25 years of narrower spectrum insecticides such as the neonicotinoids and tetramic acid insecticides for sucking insect pests, and diamides and spinosyns for chewing insect pests such as lepidopterans . This situation provides the opportunity to conceive of and patent potential mixtures of insecticides to address the needs for controlling broad complexes of sap‐feeding and chewing (e.g.…”

Section: Trendsmentioning

confidence: 99%

Intellectual property in entomology: Analysis and perspective on recent trends in global patent publications

Hamm

Gregg²,

Sparks

2020

Pest Management Science

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Intellectual property (IP) is an important consideration for entomological research and provides a means to capture value from new discoveries. Herein, we describe an analysis of more than 26 000 patent publications from 2007–2017 related to the field of entomology. These patents were divided among 8000 patent assignees; however, only 5% of the assignees had ≥10 patents. Corporations accounted for the largest share of patents (59%), with individuals (20%), academic institutions (17%) and government organizations (4%) making up the remaining segments. From 2007–2017 the number of entomological patents increased by 400%, with the largest number being from China. However, unlike patents from Europe, Japan or the US, which target a range of countries, the Chinese patents almost exclusively focus on China. Among the array of subjects covered are transgenic insects and plants, repellents, recombinant insect cells, with the highest proportion of patents focused on insecticides (39%), followed by insecticide mixtures (27%) and formulations (21%). The top 30 patent assignees included companies/institutions from China (18), Europe (3), Japan (6) and the US (3). Among the top 12 entities, IP from the US assignees was distributed across insecticides, mixtures and insecticidal traits while those from China were more focused on mixtures. However, given expanding IP numbers from China it is expected that in the future there will be a greater impact on new insecticides and related technologies. © 2020 Society of Chemical Industry

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“…Thus, to maintain a useful chemical arsenal for controlling mosquitoes and their transmission of pathogens, the discovery and development of insecticides with novel modes of action are required (Hemingway et al, 2006;Shaw and Catteruccia, 2019). Plant secondary metabolites are valuable resources for discovering and developing new insecticides Norris et al, 2018;Sparks et al, 2019). Notably, several successful classes of insecticides exploit similar modes of action as plant secondary metabolites, including pyrethroids, neonicotinoids, carbamates, and diamides.…”

Section: Introductionmentioning

confidence: 99%

Stop the crop: insights into the insecticidal mode of action of cinnamodial against mosquitoes

Kalsi

Walter

Lee

et al. 2020

Preprint

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Cinnamodial (CDIAL) is a drimane sesquiterpene dialdehyde found in the bark of Malagasy medicinal plants (Cinnamosma species; family Canellaceae). We previously demonstrated that CDIAL was insecticidal, antifeedant, and repellent against Aedes aegypti mosquitoes. The goal of the present study was to generate insights into the insecticidal mode of action for CDIAL, which is presently unknown. We evaluated the effects of CDIAL in vitro on the contractility of the ventral diverticulum (crop) in adult female Ae. aegypti. The crop is a food storage organ surrounded by visceral muscle that spontaneously contracts in vitro. We found that CDIAL completely inhibited spontaneous contractions of the crop as well as those stimulated by the agonist 5-hydroxytryptamine. Several derivatives of CDIAL with known insecticidal activity also inhibited crop contractions. Morphometric analyses of crops suggested that CDIAL induced a tetanic paralysis that was dependent on extracellular Ca 2+ and inhibited by Gd 3+ , a non-specific blocker of plasma membrane Ca 2+ channels. Screening of numerous pharmacological agents revealed that a Ca 2+ ionophore (A23187) was the only compound other than CDIAL to completely inhibit crop contractions via a tetanic paralysis. Taken together, our results suggest that CDIAL inhibits crop contractility by elevating intracellular Ca 2+ through the activation of plasma membrane Ca 2+ channels thereby leading to a tetanic paralysis, which may explain the insecticidal effects of CDIAL against mosquitoes. Our pharmacological screening efforts also revealed the presence of two regulatory pathways in mosquito crop contractility not previously described: an inhibitory glutamatergic pathway and a stimulatory octopaminergic pathway. The latter was also completely inhibited by CDIAL.

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The new age of insecticide discovery-the crop protection industry and the impact of natural products

Cited by 97 publications

References 36 publications

Review on natural products databases: where to find data in 2020

Review on natural products databases: where to find data in 2020

Intellectual property in entomology: Analysis and perspective on recent trends in global patent publications

Stop the crop: insights into the insecticidal mode of action of cinnamodial against mosquitoes

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