The Neutrophil-to-Lymphocyte Ratio Predicts Malignant Potential in Intraductal Papillary Mucinous Neoplasms

Abstract

Preoperative NLR is a useful supportive marker to predict IPMC in patients with IPMN.

Elevated NLR in gallbladder cancer and cholangiocarcinoma – making bad cancers even worse: results from the US Extrahepatic Biliary Malignancy Consortium

“…This finding is consistent with other smaller studies demonstrating that elevated NLR portends poor prognosis in solid tumor malignancies. [1][2][3][4][5][6][7][8][9][10][11][12][13] Other studies in patients with hepato-pancreato-biliary (HPB) cancers agree with the findings presented in this paper. In a study of 452 patients who underwent a HPB procedure for malignant disease, NLR >5 was found to be associated with worse OS.…”

Predictive performance of factors associated with malignancy in intraductal papillary mucinous neoplasia of the pancreas

“…1). Of these studies, 33 investigated mural nodules5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 21 examined dilatation of the main pancreatic duct (MPD)7 9, 15 16, 18 21, 23 26, 27 30, 32 36, 38, 39, 40, 41, 42, 43, 44, 45, 46, 21 analysed cyst size5 7, 8, 9 14, 15 18, 20 23, 25 27, 28 31, 36 38, 40 41, 43 47, 48, 49, 17 assessed CA19‐9 increase…”

Updates and Critical Evaluation on Novel Biomarkers for the Malignant Progression of Intraductal Papillary Mucinous Neoplasms of the Pancreas

“…Also, preoperative NLR, in intraductal papillary mucinous carcinoma (IPMC), was significantly higher in patients with IPMC (2,510±8.4 cells/mm 3 ) than in patients with IPMN (2,010±7.1 cells/mm 3 , p=0.0079) and healthy volunteers (1,370±3.3 cells/mm 3 , p<0.0001) (80). NLR was significantly reduced after curative tumor resection.…”

“…The main duct type (p=0.0231) and NLR >2.074 (p=0.0329) were independent predictors of IPMC in all patients. Combined criteria, including international consensus guidelines, CA19-9 >37 IU/ml and NLR >2.074, showed a high positive predictive value of 78 % and high specificity of 96% (80). Table I restates the promising biomarkers in order to study the clinical management of IPMNs.…”