The Neutrophil-to-Lymphocyte Ratio Correlates with Age in Patients with Papillary Thyroid Carcinoma

Liu, Jifeng; Du, Jing; Fan, Jinchuan; Liu, Kun; Zhang, Bing; Wang, Shaoxin; Wang, Wei; Wang, Zhaohui; Cai, Yongcong; Li, Chunhua; Yu, Tao; Zhu, Guiquan; Chen, Jin; Li, Chao

doi:10.1159/000375534

Cited by 40 publications

(51 citation statements)

References 19 publications

(35 reference statements)

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“…and Kocer et al 13. were in accord with this, but Liu et al .’s14 only for patients 45 years and older. However, Liu et al 14.…”

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confidence: 62%

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Association between neutrophil-to-lymphocyte ratio and differentiated thyroid cancer: a meta-analysis

Liu

et al. 2016

Sci Rep

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The association between neutrophil-to-lymphocyte ratio (NLR) and differentiated thyroid cancer (DTC) is undecided. To rectify this question, we conducted a systematic meta-analysis based on 7 prospective cohort studies published between 2013 and 2015, comprising 7349 patients. Six of these cohorts included pretreatment (baseline) NLR data for patients with thyroid nodules. The meta-analysis of these 6 cohorts showed that the NLR of patients with DTC (4617 cases) was statistically similar to patients with benign nodules only (1666 cases), with a mean difference (MD) of 0.19 (95% CI: −0.09 to 0.46; I2 = 93%; P < 0.001). No significant difference in NLR was found between patients with DTC and patients with benign nodules. Two studies addressed an association between NLR and papillary thyroid carcinoma in patients stratified by age <45 and ≥45 years (496 and 891 cases, respectively); the pooled MD was 0.09 (95% CI: −0.37 to 0.55; I2 = 92.2%, P < 0.001). An elevated NLR seems not a reliable indicator of progressing DTC in patients with goiters, and there was no difference in NLR between patients aged <45 years and those aged ≥45 years. Well-designed and large-scale investigations are warranted to understand the value of NLR in the prognosis of DTC.

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“…and Kocer et al 13. were in accord with this, but Liu et al .’s14 only for patients 45 years and older. However, Liu et al 14.…”

mentioning

confidence: 62%

“…Therefore, 7 studies comprising 7349 patients, published between 2013 and 2015, were included in the present meta-analysis4121314151617 (Table 1). Three studies were conducted in Korea12151617, three studies were performed in China, and one in Turkey13.…”

Section: Resultsmentioning

confidence: 99%

Association between neutrophil-to-lymphocyte ratio and differentiated thyroid cancer: a meta-analysis

Liu

et al. 2016

Sci Rep

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“…This serves as a well-established biomarker of subclinical atherosclerosis, which is a risk factor for cardiovascular disease and thus can be used to predict cardiovascular events. 25 The NLR has been reported to be a potential biomarker of inflammation in tumours, 26,27 cardiovascular conditions 28 and diabetes and its complications. 29,30 The precise mechanisms that lead to this higher level of NLR in DM are not quite clear, but Li et al 25 claim that it might be a result of inflammatory responses.…”

Section: Immune Componentsmentioning

confidence: 99%

Diabetes mellitus: A review of some of the prognostic markers of response to treatment and management

Agu

2018

JMH

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Background: The WHO defined ‘diabetes mellitus’ (DM) as a metabolic disorder characterised by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from the defect in insulin secretion, or inaction, or both. When not identified early and controlled, acute and chronic life-threatening consequences may result. Identifying DM early for treatment and management, as well as clinically monitoring recovery and improvement during treatment, involves the assessments of biomarkers. The types, choice, sensitivity and descriptive information trends of these biomarkers are very important. Aim: Some prognostic biomarkers and parameters that this review identified include glycated haemoglobin, white blood cells, mean neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, total leukocytes and neutrophils, plasma low-density lipoprotein, high-density lipoprotein and very low-density lipoprotein, platelet, fibrinogen, D-dimer and C-reactive proteins. Results: These parameters display increases in DM, while red blood cell, haemoglobin concentration, activated partial thromboplastin time, prothrombin time and partial thromboplastin time are decreased. Conclusion: With sound knowledge of the variations of these markers and parameters, observed reversal during treatment and management of DM and its complications can be better monitored, and guided decisions can be made.

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“…Despite these limitations, our study has several potential strengths. Whereas previous studies covered a broad thyroid cancer spectrum from differentiated thyroid cancer to anaplastic thyroid carcinoma, [12][13][14][15] our study investigated only conventional PTCs.…”

Section: )mentioning

confidence: 99%

“…10) Among these inflammatory parameters, the pretreatment high neutrophil-to-lymphocyte ratio (NLR) has been especially associated with adverse outcomes in various cancer entities. 11) In patients with thyroid cancers, a higher NLR has been associated with larger tumor size, 12,13) high stage, 14) old age, 13,14) and poorer differentiated cancer. 15) Therefore, we investigated whether preoperative NLR is associated with poor prognostic outcomes in conventional PTCs (cPTCs) which comprises the majority of thyroid malignancies.…”

Section: Introductionmentioning

confidence: 99%

Preoperative High Neutrophil-Lymphocyte Ratio May Be Associated with Lateral Lymph Node Metastasis in Patients with Papillary Thyroid Cancers

et al. 2018

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Background and Objectives:The present study investigated the association between preoperative neutrophilto-lymphocyte ratio (NLR) and poor prognostic outcomes in conventional papillary thyroid carcinomas (cPTCs). Materials and Methods: Two hundred and five patients who underwent total thyroidectomy for cPTCs larger than 10 mm were evaluated retrospectively. Patients were classified into the low NLR (n=103) and high NLR (n=102) groups by the median NLR value (1.78) and logistic regression analysis was used to evaluate whether the NLR predicted aggressive PTC features. Patients were also classified into the disease-free (n=183) and persistence/recurrence (n=22) groups and Cox regression analysis was used to investigate factors affecting persistence/recurrence by Cox regression analysis. Results: The high NLR group had a higher presence of lateral lymph node metastasis (p=0.004) and higher radioactive iodine doses (p=0.006) than the low NLR group. High NLR was an independent predictor of lateral lymph node metastasis (LNM) (OR, 2.786; p=0.005) but was not significantly associated with persistence/recurrence. Conclusion: Preoperative high NLR was an independent predictor of lateral LNM in cPTCs.

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The Neutrophil-to-Lymphocyte Ratio Correlates with Age in Patients with Papillary Thyroid Carcinoma

Cited by 40 publications

References 19 publications

Association between neutrophil-to-lymphocyte ratio and differentiated thyroid cancer: a meta-analysis

Association between neutrophil-to-lymphocyte ratio and differentiated thyroid cancer: a meta-analysis

Diabetes mellitus: A review of some of the prognostic markers of response to treatment and management

Preoperative High Neutrophil-Lymphocyte Ratio May Be Associated with Lateral Lymph Node Metastasis in Patients with Papillary Thyroid Cancers

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