The Neutrophil-to-Lymphocyte Ratio as a Simple Tool to Predict Severe Acute Cholecystitis and Mortality

Vela-Polanco, F F; Somalo, A. Pinillos; Escartín, Alfredo; Quezada, Jimy Harold Jara; Daigües, M.L. Gonzalez; Roses, H. Salvador; Álvarez, P. Muriel; Kissler, Jorge Juan Olsina

doi:10.1016/j.hpb.2021.08.599

Cited by 2 publications

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“…In their study conducted on 214 patients diagnosed with AC, Polanco et al found that with a cut off value of 12.48, NLR could predict mortality with 70% sensitivity, and 70% specificity (17). Furthermore, NLR was reported as an independent predictor of mortality in a multivariate analysis (17). In our study, we concluded that, with a cut-off value of 11.07, NLR had the potential to predict mortality with higher sensitivity.…”

Section: Discussionsupporting

confidence: 57%

“…The manifestations of inflammatory response are neutrophilia and lymphopenia (16). In their study conducted on 214 patients diagnosed with AC, Polanco et al found that with a cut off value of 12.48, NLR could predict mortality with 70% sensitivity, and 70% specificity (17). Furthermore, NLR was reported as an independent predictor of mortality in a multivariate analysis (17).…”

Section: Discussionmentioning

confidence: 98%

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Evaluation of inflammatory biomarkers affecting mortality in acute cholecystitis in the emergency department

VURAL,

DUYAN,

SARIDAS

et al. 2024

BLL

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OBJECTIVES: The aim of this study was to investigate the effectiveness of pan-immune inflammation value (PIV), systemic immune-inflammatory index (SII), and systemic inflammation response index (SIRI) in predicting mortality in acute cholecystitis (AC). BACKGROUND: Abdominal pain is one of the most frequent complaints encountered by physicians at emergency department (ED). METHODS: This clinical study is a cross-sectional study among patients admitted to the emergency department of a tertiary hospital and diagnosed with AC. Total survival curves were estimated by the Kaplan-Meier method. Differences according to risk groups were determined by the log-rank test. RESULTS: A total of 789 patients (survival: 737, non-survival: 52) diagnosed with AC were enrolled in the study. NLR and SII had an excellent diagnostic power in predicting 30-day mortality in the receiver operating characteristic (ROC) analysis, while the diagnostic power of SIRI and PIV was acceptable. It was observed that the probability of survival period decreased in the presence of NLR (>11.07), SII (>2315.18), SIRI (>6.55), and PIV (>1581.13) above the cut-off levels.

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Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 98%

Evaluation of inflammatory biomarkers affecting mortality in acute cholecystitis in the emergency department

VURAL,

DUYAN,

SARIDAS

et al. 2024

BLL

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A Prospective Study to Evaluate the Use of Neutrophil-to-Lymphocyte Ratio as a Prognostic Marker for Severe Acute Cholecystitis

Prabhu,

Togale

2024

Journal of the Scientific Society

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Context: Acute cholecystitis (AC) is one of the most common afflictions of the gastrointestinal system presenting to hospitals whose delayed diagnosis can lead to severe complications. Neutrophil-to-lymphocyte ratio (NLR) is a new and inexpensive predictor of severe AC that can be used as prognostic biomarker for the stratification of patients for appropriate management. Aims: The aims of the study are to determine the usefulness of the NLR as a prognostic marker and to find range that distinguishes between grades of AC and to compare NLR use with white blood cell, high sensitivity C-reactive protein, and radiological modalities in the diagnosis of severe AC. Settings and Design: This is a 1-year prospective observational study in tertiary care center. Subjects and Methods: Demographic data, investigations, and management of 110 patients diagnosed with AC were collected. Categorization in mild, moderate, or severe AC group was based on Tokyo guidelines and NLR was calculated as absolute neutrophil count/absolute lymphocyte count. Statistical Analysis Used: One-way analysis of variance. Results: Sixty-four were male and 46 were female. 23.64% had severe AC, 30.91% had moderate, and 45.45% had mild AC. Mean hospital stay and intensive care unit stay were more in severe cholecystitis group. Diabetes mellitus was commonly associated comorbidity in severe cholecystitis (35.48%). As per the study, NLR ranges <6.5 in mild, 6.5–10 in moderate, and >10 in severe AC (sensitivity of 97% and specificity of 88%). The cardiovascular system was most commonly affected in severe AC, followed by renal derangement. Conclusions: NLR has proved to be a prognostic marker to determine disease severity in patients with AC which will help in appropriate management and better patient outcome.

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The Neutrophil-to-Lymphocyte Ratio as a Simple Tool to Predict Severe Acute Cholecystitis and Mortality

Cited by 2 publications

References 0 publications

Evaluation of inflammatory biomarkers affecting mortality in acute cholecystitis in the emergency department

Evaluation of inflammatory biomarkers affecting mortality in acute cholecystitis in the emergency department

A Prospective Study to Evaluate the Use of Neutrophil-to-Lymphocyte Ratio as a Prognostic Marker for Severe Acute Cholecystitis

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