The neutrophil to lymphocyte ratio can discriminate anaplastic thyroid cancer against poorly or well differentiated cancer

Cho, Jin Seong; Park, Min‐Ho; Ryu, Young-Jae; Yoon, Junghan

doi:10.4174/astr.2015.88.4.187

Cited by 38 publications

(59 citation statements)

References 29 publications

(31 reference statements)

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“…86 In a recent study, NLR failed to discriminate benign and malignant lesions. 87 Thus, the diagnostic and prognostic significance of NRL in TCs remains uncertain. No studies are so far available investigating the occurrence, roles and prognostic significance of tumor-associated neutrophils in TC.…”

Section: Dendritic Cells (Dcs)mentioning

confidence: 99%

The immune network in thyroid cancer

2016

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The immune system plays critical roles in tumor prevention, but also in its initiation and progression. Tumors are subjected to immunosurveillance, but cancer cells generate an immunosuppressive microenvironment that favors their escape from immune-mediated elimination. During chronic inflammation, immune cells can contribute to the formation and progression of tumors by producing mitogenic, prosurvival, proangiogenic and lymphangiogenic factors. Thyroid cancer is the most frequent type of endocrine neoplasia and is the most rapidly increasing cancer in the US. In this review, we discuss recent findings on how different immune cells and mediators can contribute to thyroid cancer development and progression.

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Section: Dendritic Cells (Dcs)mentioning

confidence: 99%

The immune network in thyroid cancer

2016

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“…Parameters of the hemogram, including immune system elements (neutrophils, lymphocytes, and platelets), are used for the assessment of diseases, and immune system elements play a role in the control of infl ammation (Yao et al 2013;Choi et al 2014).…”

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confidence: 99%

Elevated neutrophil-lymphocyte ratio in patients with euthyroid chronic autoimmune thyreotidis

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et al. 2016

Endocrine Regulations

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Objective. Th e neutrophil-lymphocyte ratio (NLR), determined from peripheral blood, is accepted as an available and practical indicator of the systemic infl ammation. In this study, we aimed to determine whether the NLR was higher in euthyroid chronic autoimmune thyreotidis (CAT) patients compared to a healthy control group.Methods. A total of 112 patients were enrolled in this study, including 59 patients with euthyroid CAT on any form of therapy and 53 healthy controls. Th e CAT patients were similar in age to the healthy control group (mean 33.9±12.8 years versus 30.2±12.4 years, p=0.10). Measurements were available for the white blood cells (WBC), neutrophils, lymphocytes, platelets, C-reactive protein (CRP), thyroid peroxidase immune antibody (anti-TPO), and anti-thyroglobulin immune antibody (anti-TG). Th e NLR and platelet-lymphocyte ratio (PLR) were calculated. Diff erences between the CAT and control groups were tested using the student's t-test and the correlations were determined using Pearson's correlation coeffi cients.Results. Th ere were no diff erences between the CAT and control groups for WBCs (7.9±0.3 and 7.4±0.2, respectively; p=0.1) or neutrophils (5.5±0.3 and 5.4±1.1; p=0.9), but lymphocytes were higher in the CAT group (3.1±0.5 vs. 2.04±0.1; p=0.05) as was the NLR (4.0±0.7 vs. 2.0±0.1; p=0.01). Th e NLR was positively correlated with CRP (r=0.6, p<0.001), anti-TPO (r=0.3, p<0.001), anti-TG (r=0.3, p=0.006), WBCs (r=0.4, p<0.001), and the PLR (r=0.73, p<0.001). Th e PLR was also higher in the CAT than the control group (p=0.02).Conclusions. In this study, we found that NLR values were higher in euthyroid CAT patients than in a healthy control group and that NLR correlated with autoantibodies used to diagnose the disease.

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“…Despite these limitations, our study has several potential strengths. Whereas previous studies covered a broad thyroid cancer spectrum from differentiated thyroid cancer to anaplastic thyroid carcinoma, [12][13][14][15] our study investigated only conventional PTCs.…”

Section: )mentioning

confidence: 99%

“…11,12) Furthermore, patients with PTC had significantly lower NLR levels than patients with poorly differentiated or anaplastic thyroid cancer. 13,15) Many studies have demonstrated that…”

Section: )mentioning

confidence: 99%

“…11) In patients with thyroid cancers, a higher NLR has been associated with larger tumor size, 12,13) high stage, 14) old age, 13,14) and poorer differentiated cancer. 15) Therefore, we investigated whether preoperative NLR is associated with poor prognostic outcomes in conventional PTCs (cPTCs) which comprises the majority of thyroid malignancies.…”

Section: Introductionmentioning

confidence: 99%

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Preoperative High Neutrophil-Lymphocyte Ratio May Be Associated with Lateral Lymph Node Metastasis in Patients with Papillary Thyroid Cancers

et al. 2018

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Background and Objectives:The present study investigated the association between preoperative neutrophilto-lymphocyte ratio (NLR) and poor prognostic outcomes in conventional papillary thyroid carcinomas (cPTCs). Materials and Methods: Two hundred and five patients who underwent total thyroidectomy for cPTCs larger than 10 mm were evaluated retrospectively. Patients were classified into the low NLR (n=103) and high NLR (n=102) groups by the median NLR value (1.78) and logistic regression analysis was used to evaluate whether the NLR predicted aggressive PTC features. Patients were also classified into the disease-free (n=183) and persistence/recurrence (n=22) groups and Cox regression analysis was used to investigate factors affecting persistence/recurrence by Cox regression analysis. Results: The high NLR group had a higher presence of lateral lymph node metastasis (p=0.004) and higher radioactive iodine doses (p=0.006) than the low NLR group. High NLR was an independent predictor of lateral lymph node metastasis (LNM) (OR, 2.786; p=0.005) but was not significantly associated with persistence/recurrence. Conclusion: Preoperative high NLR was an independent predictor of lateral LNM in cPTCs.

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The neutrophil to lymphocyte ratio can discriminate anaplastic thyroid cancer against poorly or well differentiated cancer

Cited by 38 publications

References 29 publications

The immune network in thyroid cancer

The immune network in thyroid cancer

Elevated neutrophil-lymphocyte ratio in patients with euthyroid chronic autoimmune thyreotidis

Preoperative High Neutrophil-Lymphocyte Ratio May Be Associated with Lateral Lymph Node Metastasis in Patients with Papillary Thyroid Cancers

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