The Neutrophil Lymphocyte Ratio as a Successful Extubation Predictor of Prolonged Intubation in Pediatric Heart Surgery

Abstract

Background: Postoperative mechanical ventilation is required in patients undergoing congenital heart surgery. However, the duration of mechanical ventilation may be extended as a result in some patients. Inflammation is a normal and expected process following surgery and the intensive care process. However, increased and prolonged inflammation increases the risk of mortality and morbidity. The neutrophil lymphocyte ratio (NLR) can be used as a new marker of inflammation in cardiovascular diseases. The aim of our study was to evaluate the association between NLR and successful extubation in pediatric patients undergoing cardiovascular surgery with prolonged intubation.

The Relationship Between Neutrophil to Lymphocyte Ratio and Clinical Outcome in Pediatric Patients After Cardiopulmonary Bypass Surgery: A Retrospective Study

“…Many potential prognostic and predictive molecular inflammatory biomarkers have now been identified in the evaluation of poor outcomes following CPB; however, none have yet entered into clinical practice. Accumulating evidence demonstrated that NLR could reflect a systemic inflammatory response (17, 18); however, there is only one study evaluating the prognosis associations of NLR in pediatric patients with CPB (19). According to the results of the study, the NLR measured before extubation displayed significantly more variation in pediatric patients with failed extubation; less variation in NLR was found in children in whom extubation was successful (20).…”

The beneficial role of simple inflammatory blood indices in pediatric cardiology

“…46,54,60 In a study by Savluk et al, NLR varied between children with failed and successful extubation (following prolonged intubation). 61 Moreover, a high preoperative NLR was associated with acute kidney injury after tetralogy of Fallot repair. 62 Therefore, NLR may be used to identify patients at risk of postoperative complications.…”