The neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in adolescent obsessive-compulsive disorder: Does comorbid anxiety disorder affect inflammatory response?

Özyurt, Gonca; Binici, Nagihan Cevher

doi:10.1016/j.psychres.2018.12.131

Cited by 37 publications

(44 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has also been reported that NLR value is signifi cantly higher in psychiatric disorders such as schizophrenia, bipolar and depressive disorders in adults, as compared to the control group (16)(17)(18). In addition, an elevation in the neutrophil lymphocyte ratio has been shown to be present in child and adolescent psychiatric diseases (19,20).…”

Section: Introductionmentioning

confidence: 96%

Evaluation of hematological inflammatory markers in children and adolescents with attention deficit/hyperactivity disorder

Uzun¹

2021

BLL

View full text Add to dashboard Cite

AIM: This study aims to investigate whether there is a relationship between attention-defi cit/hyperactivity disorder (ADHD) and infl ammation, using hematologic infl ammatory parameters in a large sample of children and adolescents. METHOD: This retrospective study comprises 347 children and adolescents with ADHD between 6 and 17 years of age who met the inclusion criteria as well as 205 healthy children and adolescents in the control group. Serum parameters such as white blood cell (WBC), neutrophil, lymphocyte, platelet, monocyte, eosinophil and basophil counts, mean platelet volume (MPV), and platelet distribution width (PDW) were recorded from complete blood count tests at the time of admission, while neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and other ratios were calculated based on these counts. RESULTS: NLR, PLR, MPV, PDW, WBC and neutrophil counts were signifi cantly higher in children and adolescents with ADHD than in the control group. In the ADHD group, NLR, WBC and neutrophil counts were signifi cantly higher in girls than in boys. CONCLUSIONS: The results of this study support the hypothesis that infl ammation plays an important role in the complex pathophysiology of ADHD. In addition, our data confi rm that easily obtainable and reliable hematological parameters can be used when investigating the role of infl ammation in ADHD etiology (Tab. 4, Ref.

show abstract

Section: Introductionmentioning

confidence: 96%

Evaluation of hematological inflammatory markers in children and adolescents with attention deficit/hyperactivity disorder

Uzun¹

2021

BLL

View full text Add to dashboard Cite

show abstract

“…Abbreviations: CI = confidence interval, OR = odds ratio, HR = hazard ratio. 17 Adolescent OCD 60 (23 had comorbid AD) 128 NLR in patients with comorbid AD greater than in controls, p = .004 Avcil 18 Adolescent ADHD 82 70 NLR in patients greater than in controls, p < .001 Mean values not reported Kuyumcu et al 19 Alzheimer 23 Heroin dependence 90 60 Patients 1.86 ± 0.89 Controls 1.30 ± 0.31 p = .011…”

mentioning

confidence: 99%

Neutrophil–lymphocyte ratio – a simple, accessible measure of inflammation, morbidity and prognosis in psychiatric disorders?

Zulfic

Weickert

et al. 2020

Australas Psychiatry

View full text Add to dashboard Cite

Objective: A narrative review to describe the utility of the neutrophil-lymphocyte ratio (NLR) as an inflammatory marker in psychiatric and non-psychiatric disorders and to discuss the potential role of NLR in psychiatric research. Conclusions: NLR is inexpensive and readily available using division of two measures obtained on routine blood testing. NLR is elevated in a number of psychiatric disorders. It can predict morbidity and mortality in a wide range of non-psychiatric conditions, but this has not been confirmed in psychiatric conditions. It can be calculated in large, pre-existing datasets to investigate clinical correlates of inflammatory processes. NLR may have a future role in identifying patients with an inflammatory phenotype who could benefit from adjunctive anti-inflammatory medications.

show abstract

“…A small negative effect was observed among three studies investigating lymphocyte levels, indicating lymphocytes were decreased in individuals with anxiety‐based disorders when compared with controls; however, this was not statistically significant (Hedges’ g = −0.20, 95% CI [−0.54, 0.14], p = .25). Moderate heterogeneity was reported between studies ( Q = 3.35, I 2 = 40, p = .19), although Uçar et al (2019) found individuals with OCD had significantly lower levels of lymphocytes, Ozyurt and Binici (2019) and Ayaydin et al (2016) did not find a statistically significant between‐group difference.…”

Section: Resultsmentioning

confidence: 97%

“…A small, nonsignificant between‐group difference was observed (Hedges’ g = 0.13, 95% CI [−0.64, 0.89], p =.74), with large heterogeneity ( Q = 15.66 , I 2 = 87, p < .001). Specifically, Ozyurt and Binici (2019) found individuals with OCD had significantly higher neutrophil levels, whereas Uçar et al (2019) found no difference between groups, and Ayaydin et al (2016) reported lower, but not statistically significant levels of neutrophils among individuals with PTSD.…”

Section: Resultsmentioning

confidence: 99%

“…OCD was the most common anxiety‐based disorder investigated ( Nstudies = 6), with single studies investigating PTSD (Ayaydin et al, 2016) and GAD (Khandaker et al, 2016). Ozyurt and Binici (2019), who recruited individuals with a primary diagnosis of OCD, also included individuals with co‐morbid generalised anxiety disorder (GAD), social anxiety disorder and specific phobia. Gariup et al (2015) used a sample of combined psychiatric disorders, from which authors extracted data specific to anxiety disorders and PTSD.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Review: Inflammation and anxiety‐based disorders in children and adolescents – a systematic review and meta‐analysis

Parsons

Roberts²,

Mills

2020

Child Adoles Ment Health

View full text Add to dashboard Cite

Background Anxiety‐based disorders are common and are often chronic with an onset during childhood or adolescence. An emerging literature has examined the role of inflammation in these disorders by measuring blood concentrations of inflammatory markers such as cytokines, C‐reactive protein (CRP) and immune markers such as white blood cell counts. However, existing results are inconsistent, with available meta‐analyses only including adult populations. We believe this is the first systematic review and meta‐analysis to investigate these inconsistencies among the population of children and adolescents. Methods A systematic search of five electronic databases was conducted to identify studies which compared inflammatory markers between individuals with an anxiety‐based disorder and healthy controls. Study quality was assessed, and pooled effect sizes (Hedges’ g) were calculated using random‐effects meta‐analyses. Results Nine independent studies were identified. The combined meta‐analysis of 16 cytokines and CRP was approaching significance; however, no significant between‐group difference was observed for meta‐analyses of individual inflammatory or immune markers. Heterogeneity was high, and quality assessments identified important limitations; primarily, small sample sizes and a lack of control over confounding variables. Conclusions Although no significant effects were observed, the small number of included studies and limitations in study or reporting quality render these findings provisional. Research in this area has the potential for important clinical implications in relation to therapeutic interventions. Important recommendations for further research are put forth.

show abstract

The neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in adolescent obsessive-compulsive disorder: Does comorbid anxiety disorder affect inflammatory response?

Cited by 37 publications

References 43 publications

Evaluation of hematological inflammatory markers in children and adolescents with attention deficit/hyperactivity disorder

Evaluation of hematological inflammatory markers in children and adolescents with attention deficit/hyperactivity disorder

Neutrophil–lymphocyte ratio – a simple, accessible measure of inflammation, morbidity and prognosis in psychiatric disorders?

Review: Inflammation and anxiety‐based disorders in children and adolescents – a systematic review and meta‐analysis

Contact Info

Product

Resources

About