The Neutrophil-Lymphocyte Ratio and its Relationship with Insulin Resistance in Obesity

Karakaya, Serdar; Altay, Mustafa; Efe, Fatma Kaplan; Karadağ, İbrahim; Ünsal, Oktay; Bulur, Oktay; Eser, Murat; Ertuğrul, Derun Taner

doi:10.3906/sag-1804-68

Cited by 24 publications

(24 citation statements)

References 16 publications

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“…In the type 2 DM group, the N/L ratio was higher than that of the control group (p=0.01). Similar studies in the literature showed a significant increase in the N/L ratio after development of insulin resistance 12 . The N/L ratio may reach a significant level by making a comparison among higher numbers of obese and total participants in studies or larger samples.…”

Section: Discussionsupporting

confidence: 78%

“…Obesity is accepted as a chronic disease, and it is recommended to be treated even if there are no other accompanying diseases. While obesity causes several metabolic disorders, it also increases systemic inflammation and may as a result lead to function disorders and damage on the tissue and organ levels 12,13 . The ALT levels in the obese non-diabetic group and the type 2 DM group were higher in comparison to the control group, but the difference was not significant (p>0.05).…”

Section: Discussionmentioning

confidence: 99%

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Comparison of Inflammation on Obese Individuals and Patients Diagnosed with Type 2 Diabetes Mellitus

Sarıkan¹

2021

jamp

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Obesity is expressed as increased body fat tissue mass. Obesity is the most frequent cause of insulin resistance. Insulin resistance leads to formation of type 2 diabetes mellitus within a period of 10-15 years. Due to this mechanism, there is a strong relationship between obesity and type 2 diabetes mellitus. This study aimed to compare obesity and type 2 diabetes mellitus, which occur with similar mechanisms, based on the inflammation they cause. Ninety-seven male and female individuals were included in the study. The participants were divided into three groups as the control group (n=31), obese group (n=33) and type 2 diabetes group (n=33). Their clinic biochemical tests were obtained retrospectively from their files and analyzed. The Neutrophil / Lymphocyte (N/L) ratios of the control, obese non-diabetic and type 2 diabetes mellitus groups were found respectively as (mean±SD) 1.76 ± 0.69, 1.95 ± 0.89 and 2.79 ± 2.16 (p=0.01). While N/L was numerically higher in the obese non-diabetic group in comparison to the control group, the difference was not statistically significant (p>0.05). This value was found to be significantly higher in the type 2 diabetes mellitus group than the other two groups (p<0.05). It is seen that type 2 diabetes mellitus development in obese non-diabetic individuals may be prevented by weight loss as a result of lifestyle changes, healthy and balanced diet, exercise and increased mobility, and this way, progression of systemic inflammation and formation of tissue and organ damage may be counteracted. In addition, if the transformation of insulin resistance into type 2 diabetes mellitus in obese individuals can be prevented, cardiovascular morbidity and mortality may decrease.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Comparison of Inflammation on Obese Individuals and Patients Diagnosed with Type 2 Diabetes Mellitus

Sarıkan¹

2021

jamp

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“…Karakaya et al showed that the N/L ratio, which is a systemic inflammation marker, increased in insulin resistance. Also, they found that positive correlations between insulin levels and the NL ratio, WBC counts, and neutrophil counts [45]. In another study, WBC subtypes and N/L ratio were reported to be independently associated with insulin resistance [46].…”

Section: Discussionmentioning

confidence: 93%

Is insulin resistance a predictor for complete response in breast cancer patients who underwent neoadjuvant treatment?

et al. 2020

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Purpose Neoadjuvant chemotherapy is the standard front-line treatment modality in locally advanced breast cancer. Achieving pathological complete response (pCR) is a significant prognostic factor for prolonged disease-free and overall survival. Insulin resistance is defined as a pathological condition in which insulin effect is impaired in peripheral target tissues such as the skeletal muscle, liver, and adipose tissue. The relationship between breast cancer and insulin resistance is controversial. In this study, our aim is to evaluate the role of insulin resistance, body mass index (BMI), metabolic syndrome, and inflammation markers to predict complete response in breast cancer patients who underwent neoadjuvant treatment. Methods Data from 55 locally advanced non-diabetic breast cancer patients, treated with neoadjuvant chemotherapy between 2015 and 2017, were retrospectively evaluated. Homeostatic model assessment, IR = insulin resistance (HOMA-IR) was calculated by using the obtained insulin and fasting blood glucose values before neoadjuvant chemotherapy (fasting insulin × fasting glucose/405). We considered a cut-off of 2.5 for insulin resistance. The systemic inflammatory index (SII), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) were calculated. Results Twenty-five patients had no insulin resistance. The most common pathologic subtype (56%) was hormone receptor (HR) positive and human epidermal growth factor receptor-2 (Her-2)-negative invasive ductal carcinoma. Sixteen (29%) patients had a pathological complete response (pCR). We found that the probability of pCR in patients with insulin resistance was 4.7 times lower than that in patients without insulin resistance [OR: 4.7 (95%CI 1.7–17.2), p = 0.01]. Conclusion Our results revealed that insulin resistance may have a negative effect on pathological complete response (pCR) following neoadjuvant therapy particularly with hormone-positive and Her-2-negative cases of non-diabetic breast cancer.

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“…However, few studies have examined the association between WBC count and IR measured by HOMA-IR. Some studies have proposed that the circulating WBC count is a biomarker for the prognoses of cardiovascular risk and IR (16)(17)(18), but the possibility of identifying IR using elevated WBC counts has not been fully investigated.…”

Section: Introductionmentioning

confidence: 99%

The Association Between White Blood Cell Count and Insulin Resistance in Community-Dwelling Middle-Aged and Older Populations in Taiwan: A Community-Based Cross-Sectional Study

Chen

Lee

et al. 2022

Front. Med.

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BackgroundInsulin resistance (IR) is a major pathophysiological factor in the development and progression of diabetes mellitus (DM). DM is highly prevalent in Taiwan and has become one of the most common health problems in family medicine and primary care. We aimed to use white blood cell count (WBC), a common physiological parameter, to develop a simple clinical prediction rule for IR in the middle-aged and old Taiwanese population.MethodsIn this cross-sectional community-based study, the participants completed a questionnaire comprising personal and medical history data and underwent anthropometric measurements and blood sampling. IR was defined as a HOMA-IR index ≥2. Independent t-test, Mann–Whitney U test, chi-square test, Pearson's correlation test, multivariate binary logistic regression, and receiver operating characteristic curves were used to evaluate the association between the WBC count and IR.ResultsA total of 398 community-dwelling middle-aged and older persons (34.9% men) with a mean age of 64.43 ± 8.45 years were enrolled for the analysis. A significant association was identified between the WBC counts and IR, with a Pearson's correlation coefficient of 0.37 (p-value <0.001). Multivariate logistic regression revealed that WBC count (OR = 1.50; 95% CI = 1.25–1.81) was an independent risk factor for IR after adjusting for confounding variables. The area under the receiver operating characteristic curve for WBC count was 0.67, and the optimal threshold value was 5.65 1,000/uL.ConclusionA high WBC count is positively related to an increased risk of IR among middle-aged and older people in Taiwan.

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The Neutrophil-Lymphocyte Ratio and its Relationship with Insulin Resistance in Obesity

Cited by 24 publications

References 16 publications

Comparison of Inflammation on Obese Individuals and Patients Diagnosed with Type 2 Diabetes Mellitus

Comparison of Inflammation on Obese Individuals and Patients Diagnosed with Type 2 Diabetes Mellitus

Is insulin resistance a predictor for complete response in breast cancer patients who underwent neoadjuvant treatment?

The Association Between White Blood Cell Count and Insulin Resistance in Community-Dwelling Middle-Aged and Older Populations in Taiwan: A Community-Based Cross-Sectional Study

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