The neutrophil-lymphocyte ratio: A promising predictor of mortality in coronary care unit patients — A cohort study

Sun, Huankun; Que, Jia-Qun; Peng, Yu; Ye, Haihao; Xiang, Huaqiang; Han, Yineng; Wang, Jie; Ji, Kangting

doi:10.1016/j.intimp.2019.105692

Cited by 32 publications

(23 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NLR level is helpful in demonstrating inflammatory activation in psychiatric disorders and could work as a reproducible biomarker in systemic inflammatory activities that could be detected routinely [ 11 , 26 ]. In the general population, Meng et al reported that the elevated NLR level was independently associated with depression symptoms among females, but not among the males [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Association between Neutrophil-to-Lymphocyte Ratio and Diabetic Depression in U.S. Adults with Diabetes: Findings from the 2009-2016 National Health and Nutrition Examination Survey (NHANES)

Wang

Zhou

2020

BioMed Research International

Self Cite

View full text Add to dashboard Cite

Objective. To determine the association between neutrophil-to-lymphocyte ratio (NLR) and clinically relevant depressive symptoms in people with diabetes. Methods. This cross-sectional study was conducted among adults (age >18) with diabetes in the National Health and Nutrition Examination Survey (NHANES) between 2009 and 2016. NLR was calculated from complete blood count. Nine-item Patient Health Questionnaire (PHQ-9) was used to measure depression, with scores ≥10 indicating the presence of clinically relevant symptoms. Multivariable logistic regression was used to calculate the odds ratio (OR) with 95% confidence interval (CI) of clinically relevant depressive symptoms in relation to the NLR. We performed the smooth curve fitting and established a weighted generalized additive model to identify the nonlinearity of NLR and depression in diabetes patients. To account for the nonlinear relationship between NLR and depression in diabetes patients, weighted two-piecewise linear model was applied. Results. We included 2,820 eligible participants, of which 371 (12.4%) had clinically relevant depressive symptoms. In the unadjusted model, the OR (95% CI) of clinically relevant depressive symptoms for the second (NLR 1.75-2.57) and third (NLR >2.57) were 1.24 (0.90, 1.70) and 1.68 (1.23, 2.30), respectively, compared to the reference group ( NLR < 1.75 ). After controlling for potential confounding factors, NLR was significantly associated with clinically relevant symptoms ( odds ratio = 1.57 , 95% confidence interval: 1.13–1.87; P for trend = .0078). Nonlinear relationships were observed, and a two-piecewise linear regression model was established. The inflection point of NLR was 2.87. To the left of the inflection point ( NLR ≤ 2.87 ), the OR (95% CIs) was 1.33 (1.07–1.66) ( P < .031 ). Conclusions. Elevated levels of NLR are independently associated with increased odds of clinically relevant depressive symptoms in people with diabetes. Prospective study is needed to further analyze the role of NLR in depression in diabetic patients.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Neutrophil-to-lymphocyte ratio (NLR) is a widely accepted biomarker for the evaluation of overall inflammation status [ 11 , 12 ]. It is cost-effective, an easily available index of the inflammatory levels that is easily obtained from complete blood counts, based on neutrophil and lymphocyte counts [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

The Association between Neutrophil-to-Lymphocyte Ratio and Diabetic Depression in U.S. Adults with Diabetes: Findings from the 2009-2016 National Health and Nutrition Examination Survey (NHANES)

Wang

Zhou

2020

BioMed Research International

Self Cite

View full text Add to dashboard Cite

show abstract

“…15 Inflammatory biomarkers could potentially be used to predict depression in diabetic patients. Abnormal increases in inflammatory blood cell parameters including neutrophil count, neutrophil-to-lymphocyte ratio, 16,17 monocyte-to-lymphocyte ratio, 18 and platelet-tolymphocyte ratio 19,20 serve as simple markers of inflammation and their ability to predict depression has been assessed. But these biomarkers involve only two types of immune-inflammatory cells and might not accurately reflect the inflammation status.…”

Section: Introductionmentioning

confidence: 99%

Association Between Systemic Immune-Inflammation Index and Diabetic Depression

Wang¹,

Zhou²,

Dai³

et al. 2021

CIA

Self Cite

View full text Add to dashboard Cite

“…Higher NLR was correlated with more advanced disease stage in autoimmune disease [17,18] and it was proved to be an independent prognosis factor in infections disease [11,19], diffuse large B-cell lymphoma [20,21], and so on. Whilst, a higher NLR predicts increased 30-day mortality in critically ill patients [13,22,23]. In this study, we observed that nonsurvivor had a higher NLR compared with survivor, and higher NLR was correlated with older age, longer PT, higher creatinine, and lower HB.…”

Section: Discussionmentioning

confidence: 45%

The prognostic value of NLR for early death in secondary Hemophagocytic lymphohistiocytosis patients: an analysis of 92 patients

Pan

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Hemophagocytic lymphohistiocytosis (HLH) a hyperinflammation disease and have high early mortality. The neutrophil-lymphocyte ratio (NLR) plays a prognostic role in various inflammation conditions. However, the role of NLR in HLH remains unknown.Results: 92 patients were collected from Sep 2014 to Dec 2019, the median age was 50 years (16-88) and 54 patients (58.6%) were male. 39 patients (42.3%) died during a 30-day follow-up. In addition, NLR was higher in nonsurvivor than survivor (P=0.005), higher NLR was correlated with older age (P=0.020), worse survival status (P=0.006), lower HB level (P=0.008), longer PT level (P=0.010), higher creatinine level (0.027) and higher IL-6 level (P=0.008)and in multivariate analysis, NLR (HR=2.508, 95%CI: 1.275-4.934), was indicated as an independent prognostic factor for early death. Conclusions: NLR was correlated with early death in HLH, suggest NLR could be used as a reference indicator for the monitoring and management of HLH.

show abstract

The neutrophil-lymphocyte ratio: A promising predictor of mortality in coronary care unit patients — A cohort study

Cited by 32 publications

References 36 publications

The Association between Neutrophil-to-Lymphocyte Ratio and Diabetic Depression in U.S. Adults with Diabetes: Findings from the 2009-2016 National Health and Nutrition Examination Survey (NHANES)

The Association between Neutrophil-to-Lymphocyte Ratio and Diabetic Depression in U.S. Adults with Diabetes: Findings from the 2009-2016 National Health and Nutrition Examination Survey (NHANES)

Association Between Systemic Immune-Inflammation Index and Diabetic Depression

The prognostic value of NLR for early death in secondary Hemophagocytic lymphohistiocytosis patients: an analysis of 92 patients

Contact Info

Product

Resources

About