The neurotrophin receptors trkA, trkB and trkC are differentially regulated after excitotoxic lesion in rat striatum

Canals, Josep M.; Checa, Núria; Marco, Sonia; Michels, Alice; Pérez‐Navarro, Esther; Alberch, Jordi

doi:10.1016/s0169-328x(99)00130-8

Cited by 34 publications

(26 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the striatum, the NGFresponsive cells are cholinergic interneurons [4,8] , and our results confirmed that 3-NP does not affect all striatal cell populations equally. [4,36] .…”

Section: Neurotrophinsupporting

confidence: 81%

See 1 more Smart Citation

3-Nitropropionic acid modifies neurotrophin mRNA expression in the mouse striatum: 18S-rRNA is a reliable control gene for studies of the striatum

2012

View full text Add to dashboard Cite

Objective The aim of the present study was to determine the changes in the mRNA levels of neurotrophins and their receptors in the striatal tissue of mice treated with 3-nitropropionic acid (3-NP). Methods At 1 and 48 h after the last drug administration, the mRNA expression of nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4/5 as well as their receptors p75, TrkA, TrkB and TrkC, was evaluated using semi-quantitative (semi-Q) and real-time RT-PCR. β-actin mRNA and ribosomal 18S (18S rRNA) were tested as internal controls. Results 3-NP treatment did not affect mRNA expression of all neurotrophins and their respective receptors equally. Also, differences in neurotrophin and receptor mRNA expression were observed between semi-Q and real-time RT-PCR. Real-time RT-PCR was more accurate in evaluating the mRNA expression of the neurotrophins than semi-Q, and 18S rRNA was more reliable than β-actin as an internal control. Conclusion Neurotrophins and their receptors expression is differentially affected by neuronal damage produced by inhibition of mitochondrial respiration with 3-NP treatment in low, sub-chronic doses in vivo.

show abstract

“…In the striatum, the NGFresponsive cells are cholinergic interneurons [4,8] , and our results confirmed that 3-NP does not affect all striatal cell populations equally. [4,36] .…”

Section: Neurotrophinsupporting

confidence: 81%

“…The expression levels of neurotrophins and their receptors change in the presence of neuronal damage, e.g., after excitotoxic lesioning of the striatum [4,8,9] .…”

Section: Introductionmentioning

confidence: 99%

3-Nitropropionic acid modifies neurotrophin mRNA expression in the mouse striatum: 18S-rRNA is a reliable control gene for studies of the striatum

2012

View full text Add to dashboard Cite

show abstract

“…In our transgenic model we detected increases in NT3 levels in SN but not in LC that could also act on TrkB receptors. This may be explained that it could be a differential regulation between the ligand and its receptor as it has been described in other brain areas (Canals et al, 1998(Canals et al, , 1999. Although we cannot rule out that the lack of a fine dissection of the LC did not allow detecting small changes in NT-3 levels.…”

Section: Discussionmentioning

confidence: 80%

Transgenic mice overexpressing the full-length neurotrophin receptor TrkC exhibit increased catecholaminergic neuron density in specific brain areas and increased anxiety-like behavior and panic reaction

Dierssen

Gratacòs

Sahún

et al. 2006

Neurobiology of Disease

Self Cite

View full text Add to dashboard Cite

“…Although it has been widely demonstrated that synaptic activity regulates neurotrophin expression (Thoenen, 1995;McAllister et al, 1999), it has been suggested that neuronal activity alone is not a sufficient stimulus for the induction of BDNF mRNA after seizures (DugichDjordjevic et al, 1992). In previous studies, we have shown that intrastriatal injection of glutamate receptor agonists induced a differential regulation of the expression of neurotrophins and their receptors (Canals et al, 1998(Canals et al, , 1999Checa et al, 2000). These results could be related to a direct activation of specific glutamate receptors, although injury-induced changes in neurotrophin expression cannot be ruled out.…”

Section: Discussionmentioning

confidence: 86%

Expression of Brain-Derived Neurotrophic Factor in Cortical Neurons Is Regulated by Striatal Target Area

et al. 2001

Self Cite

View full text Add to dashboard Cite

Changes in BDNF expression after different types of brain insults are related to neuroprotection, stimulation of sprouting, and synaptic reorganization. In the cerebral cortex, an autocrine-paracrine mechanism for BDNF has been proposed because the distribution patterns of BDNF and TrkB expression are almost identical. Moreover, cortical BDNF is anterogradely transported to the striatum, suggesting a role of BDNF in the functional interaction between the two brain regions. Here we have examined the expression of this neurotrophin in the cerebral cortex after various striatal lesions. Intrastriatal injection of quinolinate, kainate, 3-nitropropionic acid, or colchicine increased BDNF mRNA levels in cerebral cortex. In contrast, stimulation of neuronal activity in the striatum did not change cortical BDNF expression. Both excitatory amino acids increased BDNF expression in neurons of cortical layers II/III, V, and VI that project to the striatum. Moreover, grafting a BDNFsecreting cell line prevented both the loss of striatal neurons and the cortical upregulation of BDNF induced by excitotoxins. Because retrograde transport in the corticostriatal pathway was intact after striatal lesions, our results suggest that striatal damage upregulates endogenous BDNF in corticostriatal neurons by a transneuronal mechanism, which may constitute a protective mechanism for striatal and/or cortical cells.

show abstract

The neurotrophin receptors trkA, trkB and trkC are differentially regulated after excitotoxic lesion in rat striatum

Cited by 34 publications

References 48 publications

3-Nitropropionic acid modifies neurotrophin mRNA expression in the mouse striatum: 18S-rRNA is a reliable control gene for studies of the striatum

3-Nitropropionic acid modifies neurotrophin mRNA expression in the mouse striatum: 18S-rRNA is a reliable control gene for studies of the striatum

Transgenic mice overexpressing the full-length neurotrophin receptor TrkC exhibit increased catecholaminergic neuron density in specific brain areas and increased anxiety-like behavior and panic reaction

Expression of Brain-Derived Neurotrophic Factor in Cortical Neurons Is Regulated by Striatal Target Area

Contact Info

Product

Resources

About