The neurotoxicological aspects of the toxic oil syndrome (TOS) in Spain

Altenkirch, H.; Stoltenburg-Didinger, G.; Koeppel, C.

doi:10.1016/0300-483x(88)90170-9

Cited by 15 publications

(8 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Workers exposed to methyl-n-butyl ketone (an ink solvent and cleaning agent) displayed peripheral neuropathy involving sensory and motor changes of the hands and feet [42,43]. Some solvents, including ethers, ketones, alcohols and various combinations, are commonly used in glues, cements and paints and can be neurotoxic when inhaled [43,48,49]. Repeated exposure to such solvents can lead to permanent neurological e ects due to severe and permanent loss of nerve cells [43,50].…”

Section: Discussionmentioning

confidence: 99%

Effects of long-term low-level solvent exposure on cognitive function

Saygun

Ekici²,

Muluk³

et al. 2012

CIM

View full text Add to dashboard Cite

TurkeyE ects of long-term low-level solvent exposure on cognitive function Abstract Purpose: e e ects of long-term low-level exposures to solvents on cognitive function were investigated.Methods: A total of 389 workers at a gun factory, those exposed to solvents (n=193) and those that were not exposed to solvents during work (n=196), were included. All the workers were given a questionnaire. Cognitive function was evaluated by Mini-mental Status Examination (MMSE) and psychological status was assessed by Hospital Anxiety and Depression (HAD) Scale. Results:No di erences were found in the MMSE and HAD scores between solventexposed workers and control workers (p>0.05). In the workers who had used a mask for a longer time, orientation scores were lower. Daytime sleepiness was related to lower recall scores.. Le -handed workers had higher total HAD scores than right-handed workers.Conclusions: Long-term low-level exposure to solvents did not a ect cognitive function in the workers, according to their MMSE scores. Duration of solvent exposure was also not related to MMSE Scores. Short sleep duration and daytime sleepiness may negatively a ect cognitive function.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of long-term low-level solvent exposure on cognitive function

Saygun

Ekici²,

Muluk³

et al. 2012

CIM

View full text Add to dashboard Cite

show abstract

“…In 1981, an unusual epidemic occurred in Spain that was traced to the ingestion of an adulterated olive oil used for cooking purposes (32). The epidemic affected at least 20,000 individuals and resulted in more than 500 deaths (33). The epidemic was quickly traced to the illegal sales of an industrial grade of rapeseed oil for human consumption under the guise of olive oil (32).…”

Section: Spanish Toxic Oilmentioning

confidence: 99%

“…The Spanish oil syndrome can be divided into two clinical phases: acute and chronic. In the acute toxic-allergic phase, most patients presented with respiratory symptoms particularly interstitial pneumonia, dyspnea, and coughing (33). Other frequent symptoms in the initial phase were fever, pruriginous skin rash, itching, nausea, vomiting, arthralgias, and myalgias (33,34).…”

Section: Spanish Toxic Oilmentioning

confidence: 99%

“…In the acute toxic-allergic phase, most patients presented with respiratory symptoms particularly interstitial pneumonia, dyspnea, and coughing (33). Other frequent symptoms in the initial phase were fever, pruriginous skin rash, itching, nausea, vomiting, arthralgias, and myalgias (33,34). Lymphadenopathy was observed in half of the patients, while moderate hepatosplenomegaly was encountered in one-third (33).…”

Section: Spanish Toxic Oilmentioning

confidence: 99%

“…Other frequent symptoms in the initial phase were fever, pruriginous skin rash, itching, nausea, vomiting, arthralgias, and myalgias (33,34). Lymphadenopathy was observed in half of the patients, while moderate hepatosplenomegaly was encountered in one-third (33). Clinical findings included marked eosinophilia, lymphopenia, elevated lactate dehydrogenase levels in serum, and increased serum IgG (33).…”

Section: Spanish Toxic Oilmentioning

confidence: 99%

See 2 more Smart Citations

Foodborne toxicants affecting the lung

Taylor

Nordlee

Kapels

1992

Pediatric Allergy Immunology

View full text Add to dashboard Cite

Foods contain several toxicants that can exert adverse effects on the lung. Some of these toxicants are naturally occurring substances such as the pyrrolizidine alkaloids, histamine, the sweet potato toxins, perilla ketone, paralytic shellfish toxins, the red tide toxins, and botulinum toxins. Other foodborne toxicants affecting the lungs are additives (nitrite, BHT, carrageenan), processing‐induced toxicants (the agent involved in Spanish toxic oil syndrome, the mutagens from cooked meats), or environmental contaminants (paraquat, PCBs, PCDFs). Some of these toxicants have primary effects on other organ systems. For example, paralytic shellfish toxins, the red tide toxin, and botulinum toxins are primarily neurotoxins whose effects on the lung are secondary. The pyrrolizidine alkaloids primarily affect the liver. However, some of the toxicants exert their primary effects on the lung (paraquat, the sweet potato toxins, perilla ketone). For some of the foodborne toxicants affecting the lungs, these effects are only noted in experimental animals fed high doses of the toxicant for prolonged periods of time. Examples would include BHT, nitrite, and carrageenan. These particular chemicals are likely to be safe to consume under more normal circumstances of exposure.

show abstract