The neurotoxicity of alkyl mercury compounds

Dales, Loring G.

doi:10.1016/0002-9343(72)90131-3

Cited by 54 publications

(11 citation statements)

References 17 publications

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“…Mercury species are not known to be carcinogenic (ATSDR, 1999; US EPA, 2000) so non-cancer health endpoints, primarily with regard to neurotoxicity (Dales, 1972;Chang, 1977;Castoldi et al, 2001) were used as the basis for risk assessment.…”

Section: Human Health and Mercury In Tutuila Coral Reef Fishmentioning

confidence: 99%

Mercury (Hg) speciation in coral reef systems of remote Oceania: Implications for the artisanal fisheries of Tutuila, Samoa Islands

Morrison

Peshut

West

et al. 2015

Marine Pollution Bulletin

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We investigated Hg in muscle tissue of fish species from three trophic levels on fringing reefs of Tutuila (14°S, 171°W), plus water, sediment and turf alga. Accumulation of total Hg in the herbivore Acanthurus lineatus (Acanthuridae, lined surgeonfish, (n =40)) was negligible at 1.05 (±0.04) ngg -1 wet-weight, (~65% occurring as methyl Hg). The mid-level carnivore Parupeneus spp. (Mullidae, goatfishes (n =10)) had total Hg 29.8 (±4.5) ngg -1 wet-weight (~99% as methyl Hg). Neither A. lineatus or Parupeneus spp. showed a propensity to accumulate Hg based on body size. Both groups were assigned a status of "un-restricted" for monthly consumption limits for non-carcinogenic health endpoints for methyl Hg. The top-level carnivore Sphyraena qenie (Sphyraenidae, blackfin barracuda, n =3) had muscle tissue residues of 105, 650 and 741ngg -1 wetweight (100% methyl Hg, with increasing concentration with body mass, suggesting that S. qenie >15kg would have a recommendation of "no consumption".

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Section: Human Health and Mercury In Tutuila Coral Reef Fishmentioning

confidence: 99%

Mercury (Hg) speciation in coral reef systems of remote Oceania: Implications for the artisanal fisheries of Tutuila, Samoa Islands

Morrison

Peshut

West

et al. 2015

Marine Pollution Bulletin

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“…Neurotransmitters pmoles accumulated/ min/100 mg protein [22]. In vitro concentrations of 0.3 µM-1.0 µM CH 3 HgCI produce disturbances in high affinity uptake of certain putative neurotransmitters.…”

Section: Treatmentmentioning

confidence: 97%

Effects of methylmercuric chloride on high affinity uptake of certain putative neurotransmitters in neuroblastoma and glioma cell cultures

1979

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SUMMARYThe effect of methylmercuric chloride (CH 3 HgCl) on high affinity uptake of certain putative neurotransmitters on mouse neuroblastoma (NBE-) and rat glioma (C-6) cells in culture 3 days after treatment was studied. The energydependent accumulation of radioactive choline was decreased in NB cells after treatment with CH 3 HgCl (1 µM), whereas the accumulation of radioactive glycine or glutamate was increased. The uptake of radioactive glycine or glutamate in glioma cells was decreased after treatment with CH 3 HgCl (0.3 µM). High affinity uptake of choline was not demonstrable in glioma cells. Low concentrations of CH 3 HgCl affect the accumulation of glycine and glutamate in glioma and NB cells in an opposite manner.

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“…The predominant neuropathological feature is degenerative changes in the cerebellum. Finally, disruption of higher cognitive function has also been seen, as evidenced by depression and irritability [54].…”

Section: In Addition To Cam Products Used In This Case Whatmentioning

confidence: 99%

Case Files of the Emory University Medical Toxicology Fellowship: Inhalational Mercury Toxicity from a Traditional Vietnamese Product

Pandalai

Morgan

2011

J. Med. Toxicol.

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The neurotoxicity of alkyl mercury compounds

Cited by 54 publications

References 17 publications

Mercury (Hg) speciation in coral reef systems of remote Oceania: Implications for the artisanal fisheries of Tutuila, Samoa Islands

Mercury (Hg) speciation in coral reef systems of remote Oceania: Implications for the artisanal fisheries of Tutuila, Samoa Islands

Effects of methylmercuric chloride on high affinity uptake of certain putative neurotransmitters in neuroblastoma and glioma cell cultures

Case Files of the Emory University Medical Toxicology Fellowship: Inhalational Mercury Toxicity from a Traditional Vietnamese Product

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