The neuroscience of adaptive thermoregulation

Angilletta, Michael J.; Youngblood, Jacob P.; Neel, Lauren K.; VandenBrooks, John M.

doi:10.1016/j.neulet.2018.10.046

Cited by 35 publications

(29 citation statements)

References 164 publications

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“…Afferent signals are then relayed to the preoptic area (POA) of the hypothalamus (Figure 3b), which represents the thermosensory processing centre in vertebrates (Morrison & Nakamura 2019). In the POA, afferent signals are processed relative to thermoregulatory set points (Angilletta et al ., 2019; Seebacher 2009). The POA can then signal sympathetic preganglionic neurons in the spinal cord via the rostral raphe pallidus (Hong & Siemens 2015), where subsequent sympathetic outflow acts to promote behavioural and physiological responses.…”

Section: Signalling Pathwaysmentioning

confidence: 99%

What do warming waters mean for fish physiology and fisheries?

Little

Loughland

Seebacher

2020

Journal of Fish Biology

125

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Environmental signals act primarily on physiological systems, which then influence higher-level functions such as movement patterns and population dynamics. Increases in average temperature and temperature variability associated with global climate change are likely to have strong effects on fish physiology and thereby on populations and fisheries. Here we review the principal mechanisms that transduce temperature signals and the physiological responses to those signals in fish. Temperature has a direct, thermodynamic effect on biochemical reaction rates. Nonetheless, plastic responses to longer-term thermal signals mean that fishes can modulate their acute thermal responses to compensate at least partially for thermodynamic effects. Energetics are particularly relevant for growth and movement, and therefore for fisheries, and temperature can have pronounced effects on energy metabolism. All energy (ATP) production is ultimately linked to mitochondria, and temperature has pronounced effects on mitochondrial efficiency and maximal capacities. Mitochondria are dependent on oxygen as the ultimate electron acceptor so that cardiovascular function and oxygen delivery link environmental inputs with energy metabolism.

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Section: Signalling Pathwaysmentioning

confidence: 99%

What do warming waters mean for fish physiology and fisheries?

Little

Loughland

Seebacher

2020

Journal of Fish Biology

125

View full text Add to dashboard Cite

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“…While progress has been made in identifying the markers and functional importance of warmsensitive POA neurons (Angilletta Jr. et al, 2019;Madden and Morrison, 2019;Siemens and Kamm, 2018;Tan and Knight, 2018), the molecular basis and physiological role of cold sensitivity in the POA has remained obscure. Here, we report the identification of CNGA3 as a cold-potentiated ion channel in a subset of cold-sensing mouse POA neurons.…”

Section: Discussionmentioning

confidence: 99%

“…The preoptic area of the hypothalamus (POA) is a key thermoregulatory region in the brain of vertebrates. It integrates signals from peripheral thermoreceptors and detects chemical cues produced by infectious agents to orchestrate physiological and behavioural thermoregulatory responses (Angilletta Jr. et al, 2019;Madden and Morrison, 2019;Siemens and Kamm, 2018;Tan and Knight, 2018). The POA of various species of mammals also contains neurons that respond to changes in local temperature (Hardy et al, 1964;Hori et al, 1980a;Kelso et al, 1982).…”

Section: Introductionmentioning

confidence: 99%

CNGA3 acts as a cold sensor in hypothalamic neurons

Feketa

Nikolaev

Merriman

et al. 2020

eLife

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Most mammals maintain their body temperature around 37°C, whereas in hibernators it can approach 0°C without triggering a thermogenic response. The remarkable plasticity of the thermoregulatory system allowed mammals to thrive in variable environmental conditions and occupy a wide range of geographical habitats, but the molecular basis of thermoregulation remains poorly understood. Here we leverage the thermoregulatory differences between mice and hibernating thirteen-lined ground squirrels (Ictidomys tridecemlineatus) to investigate the mechanism of cold sensitivity in the preoptic area (POA) of the hypothalamus, a critical thermoregulatory region. We report that, in comparison to squirrels, mice have a larger proportion of cold-sensitive neurons in the POA. We further show that mouse cold-sensitive neurons express the cyclic nucleotide-gated ion channel CNGA3, and that mouse, but not squirrel, CNGA3 is potentiated by cold. Our data reveal CNGA3 as a hypothalamic cold sensor and a molecular marker to interrogate the neuronal circuitry underlying thermoregulation.

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“…The top‐down response to temperature involves: (1) the input of thermal information from sensory neurons and integration in the central nervous system, and (2) the resulting production of a thermoregulatory response, which can be both physiological and behavioral, such as hormone release, regulation of peripheral blood flow, movement, induction of a specific posture (Angilletta et al, 2019). These behavioral changes are mainly stimulus–response reflexes.…”

Section: The State Of Knowledgementioning

confidence: 99%

The impacts of heat stress on animal cognition: Implications for adaptation to a changing climate

Soravia

Ashton

Thornton

et al. 2021

WIREs Climate Change

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With global surface air temperature rising rapidly, extensive research effort has been dedicated to assessing the consequences of this change for wildlife. While impacts on the phenology, distribution, and demography of wild animal populations are well documented, the impact of increasing temperature on cognition in these populations has received relatively little attention. Cognition encompasses the mental mechanisms that allow individuals to process information from the surrounding environment, respond accordingly, and flexibly adjust behavior. Hence, it is likely to be a key factor in allowing animals to adjust adaptively to climate change. Captive studies show that heat stress can negatively affect cognitive performance not only in the short‐term but also in the long‐term, by altering cognitive development at early life stages. Field studies indicate that cognitive performance may affect survival and reproductive success. However, the link between heat stress, cognition, and fitness in wild animals has yet to be formally established. We propose a comprehensive research framework for the collection of robust empirical datasets on heat stress and cognitive performance in the wild. We then suggest how knowledge of heat stress impacts on cognitive performance could be applied to population viability models and wildlife management actions. We believe that a joint research effort encompassing the fields of thermal physiology, behavioral ecology, comparative cognition, and conservation science, is essential to provide timely mitigation measures against the potential impacts of climate change on wildlife. This article is categorized under: Climate, Ecology, and Conservation > Observed Ecological Changes

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The neuroscience of adaptive thermoregulation

Cited by 35 publications

References 164 publications

What do warming waters mean for fish physiology and fisheries?

What do warming waters mean for fish physiology and fisheries?

CNGA3 acts as a cold sensor in hypothalamic neurons

The impacts of heat stress on animal cognition: Implications for adaptation to a changing climate

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