The neuroscience and genomics of social behavior

Vibrating Tail, Digging, Body/Face Interaction, and Lack of Barbering: Sex-Dependent Behavioral Signatures of Social Dysfunction in 3xTg-AD Mice as Compared to Mice with Normal Aging

“…The present work using a social paradigm of genotype and sex-matched dyads contributes to the growing efforts to study social behaviors in rodents [1,9] with special attention to its complexity in models of AD (i.e., [25,27,[29][30][31]). This is important because several studies have shown that social environment (rearing conditions, enrichment, cohabitation, isolation, psychosocial stress) can be determinant and exert distinct impact in cognitive and BPSD-like symptoms as well as underlying neurobiological substrates and AD neuropathology [30,[33][34][35].…”

“…At the translational level, modeling behavioral and psychological symptoms of dementia (BPSD) in murine models of AD has been addressed using methodological approaches based on the interaction of the subject with the environment, but few involve the relation with other individuals [8]. Furthermore, social neuroscience efforts to fill the gap are also foreseen as important to improve the predictive validity of new preventive and/or therapeutic strategies for AD [9].…”