The Neuropsychology of Pediatric Epilepsy and Antiepileptic Drugs

Bennett, Thomas L.; Ho, Maile R.

doi:10.1007/978-0-387-78867-8_21

Cited by 3 publications

(1 citation statement)

References 96 publications

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“…Language is generally considered a cortical function, usually in the left hemisphere, and the deep gray matter of the hippocampus is also known to be involved in verbal memory (Lezak 1995). Temporal lobe epilepsy research has demonstrated an association between deficits in these functions in patients with known cortical abnormalities (Bennett and Ho 1989). And patients with known white matter lesions were found to be unaffected on verbal list-learning tasks (de Groot and Hofman 2000).…”

Section: Theoretical Models For Neurocognitive Changesmentioning

confidence: 99%

White versus gray matter function as seen on neuropsychological testing following bone marrow transplant for acute leukemia in childhood

Anderson¹,

Kunin‐Batson²,

Perkins³

et al. 2008

NDT

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Current theory suggests that neurocognitive late effects of treatments for childhood cancer such as diffi culties with attention, processing speed and visual-motor ability are the result of white matter damage. Neuroimaging studies have produced a variety of white matter fi ndings. However, although white matter is thought to be differentially affected, previous studies have not demonstrated a discrepancy between white and gray matter function. The present study included 36 children treated for childhood leukemia with hematopoietic stem cell transplant (HCT). Their performance on neurocognitive measures traditionally thought to measure white matter was compared to performance on measures thought to measure gray matter function. Composite white and gray matter standard scores were created based on neuropsychological measures that individuals with known white or gray matter damage perform poorly. As predicted, composite white matter scores (mean = 98.1) were signifi cantly lower (t = 2.26, p = 0.03) than composite gray matter scores (mean = 102.5). Additionally, as gray matter performance increased, the difference between gray and white matter scores increased (R = 0.353, p = 0.035). Overall, the results of this study support the current theory that white matter damage is responsible for the more subtle neurocognitive late effects resulting from treatment for childhood leukemia.

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Section: Theoretical Models For Neurocognitive Changesmentioning

confidence: 99%

White versus gray matter function as seen on neuropsychological testing following bone marrow transplant for acute leukemia in childhood

Anderson¹,

Kunin‐Batson²,

Perkins³

et al. 2008

NDT

View full text Add to dashboard Cite

show abstract

References

2010

Neuropsychological Assessment and Intervention for Childhood and Adolescent Disorders

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Behavioral Problems and Intelligence Quotient Changes in Pediatric Epilepsy: A Case–Control Study

Choudhary

Niranjan

Khichar

et al. 2017

Journal of Neurosciences in Rural Practice

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Background:Epilepsy is the most common chronic neurological disease and has neurological impairment as an important comorbidity.Objective:To find behavioral problems and intelligence quotient (IQ) changes associated with epilepsy and to know the association of variables such as frequency, type of seizures, and duration of disease with cognitive impairment.Materials and Methods:A descriptive cross sectional study, consisting of 50 cases (patients of epilepsy) and 50 controls (other patients of same socioeconomic status) was conducted at S.P. Medical College, Bikaner. The patients were subjected to detailed clinical history, thorough examination, Pediatric Symptom Checklist, and Bhatia's Battery of Performance intelligence Test. Data analysis was carried out with the help of SPSS 22 software.Results:The prevalence of behavioral problems in generalized and partial seizure group was high (42% and 53.8%) as compared to control group (9%). Low IQ was present more in the patients (44%) of generalized and partial seizure group as compared with the control group, and results were statistically significant. Furthermore, behavioral problems were more in patients who were having more number of seizures (≥3 per year) with significant P values (χ2 = 5.067, P = 0.024).Conclusion:We conclusively found that behavioral problems and cognitive factors, apart from control of seizures, must be kept in mind to determine how well a child with epilepsy progresses toward independence.

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The Neuropsychology of Pediatric Epilepsy and Antiepileptic Drugs

Cited by 3 publications

References 96 publications

White versus gray matter function as seen on neuropsychological testing following bone marrow transplant for acute leukemia in childhood

White versus gray matter function as seen on neuropsychological testing following bone marrow transplant for acute leukemia in childhood

References

Behavioral Problems and Intelligence Quotient Changes in Pediatric Epilepsy: A Case–Control Study

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