The Neuropsychology of Amphetamine and Opiate Dependence: Implications for Treatment

Ersche, Karen D.; Sahakian, Barbara J.

doi:10.1007/s11065-007-9033-y

Cited by 133 publications

(89 citation statements)

References 249 publications

(369 reference statements)

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“…It has been shown that deficits in cognitive control are associated with a reduced capacity to recognize problems with substance abuse, lower motivation to enter treatment and treatment dropout. 133,134 Berkman and colleagues 66 showed that individual differences in activation in the inhibitory control network are linked to the ability to inhibit craving in daily life to prevent smoking. These and other recent findings 135 highlight the need to monitor cognitive control capacities during treatment and may be used to identify individuals with addictions who are more vulnerable to relapse.…”

Section: Treatment Implications and Future Research Directionsmentioning

confidence: 99%

Systematic review of ERP and fMRI studies investigating inhibitory control and error processing in people

Luijten

Machielsen

Veltman

et al. 2014

J Psychiatry Neurosci

318

300

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Section: Treatment Implications and Future Research Directionsmentioning

confidence: 99%

Systematic review of ERP and fMRI studies investigating inhibitory control and error processing in people

Luijten

Machielsen

Veltman

et al. 2014

J Psychiatry Neurosci

318

300

View full text Add to dashboard Cite

“…Depending on their neurocognitive profile, addicted individuals may subsequently be allocated to more appropriate or targeted treatment interventions, rather than following a 'one size fits all' approach (Ersche & Sahakian, 2007;King & Canada, 2004). However, in order to translate the present findings into guidelines for treatment matching, several questions need to be addressed.…”

Section: Implications For Treatment Allocationmentioning

confidence: 99%

“…Risky decision-making on the CGT for example, may be due to an impairment in accurately estimating outcome probabilities instead of reflecting impulsive reward-seeking per se (Ersche & Sahakian, 2007). Although interference effects on drug-versions of the Stroop task have predominantly been explained as reflecting a selective, rapid, automatic processing bias, alternative explanations should be considered.…”

Section: Limitations Of the Reviewmentioning

confidence: 99%

Impulsivity as a vulnerability factor for poor addiction treatment outcomes: A review of neurocognitive findings among individuals with substance use disorders

Stevens

Verdejo-García

Goudriaan

et al. 2014

Journal of Substance Abuse Treatment

266

178

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With the current review, we explore the hypothesis that individual differences in neurocognitive aspects of impulsivity (i.e., cognitive and motor disinhibition, delay discounting and impulsive decision-making) among individuals with a substance use disorder are linked to unfavorable addiction treatment outcomes, including high drop-out rates and difficulties in achieving and maintaining abstinence. A systematic review of the literature was carried out using PubMed, PsycINFO and Web of Knowledge searches. Twenty-five unique empirical papers were identified and findings were considered in relation to the different impulsivity dimensions. Although conceptual/methodological heterogeneity and lack of replication are key limitations of studies in this area, findings speak for a prominent role of cognitive disinhibition, delay discounting and impulsive decision-making in the ability to successfully achieve and maintain abstinence during and following addiction treatment. In contrast, indices of motor disinhibition appear to be unrelated to abstinence levels. Whereas the relationship between impulsivity and treatment retention needs to be examined more extensively, preliminary evidence suggests that impulsive/risky decision-making is unrelated to premature treatment drop-out among individuals with a substance use disorder. The reviewed findings are discussed in terms of their clinical implications.

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“…These include increased impulsivity, cognitive inflexibility, and impaired decision making (Bechara et al, 2001;Monterosso et al, 2001;Ersche and Sahakian, 2007;Simon et al, 2007;Floresco and Whelan, 2009). Similarly, neuroimaging has revealed abnormal activation of the prefrontal cortex (PFC) and the amygdala of abusers (London et al, 2004;Ersche et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Repeated Amphetamine Exposure Disrupts Dopaminergic Modulation of Amygdala–Prefrontal Circuitry and Cognitive/Emotional Functioning

Tse¹,

Cantor²,

Floresco³

2011

J. Neurosci.

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Repeated exposure to psychostimulants such as amphetamine (AMPH) disrupts cognitive and behavioral processes mediated by the medial prefrontal cortical (mPFC) and basolateral amygdala (BLA). The present study investigated the effects of repeated AMPH exposure on the neuromodulatory actions of dopamine (DA) on BLA-mPFC circuitry and cognitive/emotional processing mediated by these circuits. Rats received five AMPH (2 mg/kg) or saline injections (controls) over 10 d, followed by 2-4 week drug washout. In vivo neurophysiological extracellular recordings in urethane-anesthetized rats were used to obtain data from mPFC neurons that were either inhibited or excited by BLA stimulation. In controls, acute AMPH attenuated BLA-evoked inhibitory or excitatory responses; these effects were mimicked by selective D 2 or D 1 agonists, respectively. However, in AMPH-treated rats, the ability of these dopaminergic manipulations to modulate BLA-driven decreases/increases in mPFC activity was abolished. Repeated AMPH also blunted the excitatory effects of ventral tegmental area stimulation on mPFC neural firing. Behavioral studies assessed the effect of repeated AMPH on decision making with conditioned punishment, a process mediated by BLA-mPFC circuitry and mesocortical DA. These treatments impaired the ability of rats to use conditioned aversive stimuli (footshock-associated cue) to guide the direction of instrumental responding. Collectively, these data suggest that repeated AMPH exposure can lead to persistent disruption of dopaminergic modulation of BLA-mPFC circuitry, which may underlie impairments in cognitive/emotional processing observed in stimulant abusers. Furthermore, they suggest that impairments in decision making guided by aversive stimuli observed in stimulant abusers may be the result of repeated drug exposure.

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The Neuropsychology of Amphetamine and Opiate Dependence: Implications for Treatment

Cited by 133 publications

References 249 publications

Systematic review of ERP and fMRI studies investigating inhibitory control and error processing in people

Systematic review of ERP and fMRI studies investigating inhibitory control and error processing in people

Impulsivity as a vulnerability factor for poor addiction treatment outcomes: A review of neurocognitive findings among individuals with substance use disorders

Repeated Amphetamine Exposure Disrupts Dopaminergic Modulation of Amygdala–Prefrontal Circuitry and Cognitive/Emotional Functioning

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