The neuroprotective effect of traditional Chinese medicinal plants—A critical review

Development of Chinese herbal medicine for sensorineural hearing loss

“…As a “living fossil”, G. biloba is known as a valuable herb and the extracts of G. biloba leaves have been used for medicinal purposes for more than 2000 years in China 97 . G. biloba leaves have been among the most widely used CHM for centuries and applied for the treatment of Alzheimer's disease, stroke, cerebrovascular disability, depression, and vascular dementia 98 , 99 . By establishing in vivo animal models and in vitro explant cultures, standardized G. biloba leaf extract (EGb761) exhibited a protective effect on gentamicin-induced ototoxicity.…”

Role of medicinal plants as antioxidants in the treatment of oxidative stress-related human health disorders

“…Available literature well explained that higher antioxidants in medicinal plants correlate with their health-protective role in combating various oxidative stress-related chronic diseases i.e., neurodegenerative disorders, cardiac problems, diabetes, cancer etc. with slight or no side effects (Eddouks et al, 2013;Hussain et al, 2018;Mostafa and Abdellatif, 2020;Moreira et al, 2023). Raimi et al…”

Identification of BACE-1 inhibitors through directed C(sp3)–H activation on 5-oxo-pyrrolidine-3-carboxylic acid derivatives

“…Just to give some examples, different Endothelin Receptor Antagonists 21 and Glutaminyl-Peptide CycloTransferase-Like (QPCTL) inhibitors, 22 used for the treatment of Alzheimer's Disease, contain a fully substituted 5-oxopyrrolidines. Also, this scaffold is present in heliotropamide A and bisavenanthramide B-6 natural products used in traditional Chinese medicine, 23 for their acetylcholinesterase inhibitory activity and their neuroprotective effects (Fig. 1).…”