The neuroprotective effect of exogen melatonin upon fetal hippocampus damage caused by high‐dose caffeine administration in pregnant rats
Yağmur Köse,
Cansın Şirin,
Ali Çağlar Turgut
et al.
Abstract:ObjectiveThe aim of this study is to evaluate whether exogenous melatonin (MEL) mitigates the deleterious effects of high‐dose caffeine (CAF) administration in pregnant rats upon the fetal hippocampus.Materials and methodsA total of 32 adult Wistar albino female rats were divided into four groups after conception (n = 8). At 9–20 days of pregnancy, intraperitoneal (i.p.) MEL was administered at a dose of 10 mg/kg/day in the MEL group, while i.p. CAF was administered at a dose of 60 mg/kg/day in the CAF group. … Show more
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