The neurophysiology of concussion

Blood-Brain Barrier Breakdown Following Traumatic Brain Injury: A Possible Role in Posttraumatic Epilepsy

“…In accordance with earlier studies [16, 23–25], we find that patients with mild to moderate TBI commonly have abnormal EEG recordings. Interestingly, although PTE patients were more likely to have interictal sharp activity on their EEG than non-epileptic post-traumatic patients, quantitative analyses did not reveal significant differences between the two groups.…”

Blood-Brain Barrier Breakdown Following Traumatic Brain Injury: A Possible Role in Posttraumatic Epilepsy

“…In accordance with earlier studies [16, 23–25], we find that patients with mild to moderate TBI commonly have abnormal EEG recordings. Interestingly, although PTE patients were more likely to have interictal sharp activity on their EEG than non-epileptic post-traumatic patients, quantitative analyses did not reveal significant differences between the two groups.…”

Mechanosensory Stimulation Evokes Acute Concussion-Like Behavior by Activating GIRKs Coupled to Muscarinic Receptors in a Simple Vertebrate

“…Our results show only the activation of rapid-transient detectors evokes KO inhibition (Fig. 2), in agreement with the observation that concussive blows have to reach certain speed to be effective (Shaw, 2002). …”

Mild TBI Changes Brain and Plasma Neurosteroid Levels in Mice

“…This confirms that loss of consciousness may occur following mTBI with little or no accompanying acute neuropathology. 38 , 44 , 54 , 55 Although our findings may seem to corroborate reports regarding mTBI mostly as a disorder of function rather than structure, 5 , 56 advanced neuroimaging such as diffusion tensor and kurtosis imaging have already challenged this view. 50 , 57 , 58 mTBI may thus be more accurately assessed as a disorder including cognitive as well as microstructural alterations, rather than an isolated paradigm.…”

Blood-Brain Barrier Breakdown Following Traumatic Brain Injury: A Possible Role in Posttraumatic Epilepsy

“…In accordance with earlier studies [16, 23–25], we find that patients with mild to moderate TBI commonly have abnormal EEG recordings. Interestingly, although PTE patients were more likely to have interictal sharp activity on their EEG than non-epileptic post-traumatic patients, quantitative analyses did not reveal significant differences between the two groups.…”

Mechanosensory Stimulation Evokes Acute Concussion-Like Behavior by Activating GIRKs Coupled to Muscarinic Receptors in a Simple Vertebrate

“…Our results show only the activation of rapid-transient detectors evokes KO inhibition (Fig. 2), in agreement with the observation that concussive blows have to reach certain speed to be effective (Shaw, 2002). …”

Mild TBI Changes Brain and Plasma Neurosteroid Levels in Mice

“…This confirms that loss of consciousness may occur following mTBI with little or no accompanying acute neuropathology. 38 , 44 , 54 , 55 Although our findings may seem to corroborate reports regarding mTBI mostly as a disorder of function rather than structure, 5 , 56 advanced neuroimaging such as diffusion tensor and kurtosis imaging have already challenged this view. 50 , 57 , 58 mTBI may thus be more accurately assessed as a disorder including cognitive as well as microstructural alterations, rather than an isolated paradigm.…”

Blood-Brain Barrier Breakdown Following Traumatic Brain Injury: A Possible Role in Posttraumatic Epilepsy

“…In accordance with earlier studies [16, 23–25], we find that patients with mild to moderate TBI commonly have abnormal EEG recordings. Interestingly, although PTE patients were more likely to have interictal sharp activity on their EEG than non-epileptic post-traumatic patients, quantitative analyses did not reveal significant differences between the two groups.…”

Mechanosensory Stimulation Evokes Acute Concussion-Like Behavior by Activating GIRKs Coupled to Muscarinic Receptors in a Simple Vertebrate

“…Our results show only the activation of rapid-transient detectors evokes KO inhibition (Fig. 2), in agreement with the observation that concussive blows have to reach certain speed to be effective (Shaw, 2002). …”

Mild TBI Changes Brain and Plasma Neurosteroid Levels in Mice

“…This confirms that loss of consciousness may occur following mTBI with little or no accompanying acute neuropathology. 38 , 44 , 54 , 55 Although our findings may seem to corroborate reports regarding mTBI mostly as a disorder of function rather than structure, 5 , 56 advanced neuroimaging such as diffusion tensor and kurtosis imaging have already challenged this view. 50 , 57 , 58 mTBI may thus be more accurately assessed as a disorder including cognitive as well as microstructural alterations, rather than an isolated paradigm.…”