The neurophysiological basis and the role of inflammatory reactions in dentine hypersensitivity

Närhi, Matti; Yamamoto, Hiroshi; Ngassapa, D; Hirvonen, T.

doi:10.1016/0003-9969(94)90184-8

Cited by 68 publications

(55 citation statements)

References 51 publications

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“…The dental pulp is frequently used for the study of pain, because this structure is innervated by both A-delta and C-fiber primary afferents (see Sessle, 1987;Narhi, 1990;Narhi et al, 1994). A large number of anatomic studies using transganglionic transport of neuronal tracers (Arvidsson and Gobel, 1981;Marfut and Turner, 1984;Shigenaga et al, 1986Shigenaga et al, , 1989Takemura et al, 1991Takemura et al, , 1993, degeneration after tooth pulp extirpation (Westrum et al, 1976;Gobel and Binck, 1977;Westrum, 1980, Johnson et al, 1983), or administration of the neurotoxin ricin (Johnson et al, 1985;Henry et al, 1987;Matthews et al, 1989) have shown that tooth pulp afferents project to the trigeminal principal sensory nucleus (Vp) and all subnuclei of spinal trigeminal nucleus: the oralis (Vo), interpolaris (Vi), and caudalis (Vc; Olszewski, 1950).…”

Section: Indexing Terms: Ultrastructure; Synapse; Immunogold; Nocicepmentioning

confidence: 99%

“…It is well known that the tooth pulp is innervated by A-delta fibers that form a nerve plexus beneath the predentin and by unmyelinated (C-fiber) primary afferents that distribute around the center of tooth pulp (Sessle, 1987;Narhi, 1990;Narhi et al, 1994). Thus, the A-delta fibers are activated by stimuli applied to the dentin and mediate fast pain, whereas the C-fibers (polymodal nociceptors) are activated mainly by chemical substances like bradykinin and mediate slow pain (Narhi et al, 1994). The present finding that DCV-type boutons were exclusively found in the superficial layers of Vc suggests that this nucleus is involved in mediation of slow pain.…”

Section: Synaptic Organization Of Tooth Pulp Afferent Terminals In Trmentioning

confidence: 99%

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Synaptic organization of tooth pulp afferent terminals in the rat trigeminal sensory nuclei

Bae

Kim

Choi

et al. 2003

J of Comparative Neurology

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Previous studies provide evidence that a structure/function correlation exists in the distinct zones of the trigeminal sensory nuclei. To evaluate this relationship, we examined the ultrastructure of afferent terminals from the tooth pulp in the rat trigeminal sensory nuclei: the principalis (Vp), the dorsomedial part of oral nucleus (Vdm), and the superficial layers of caudalis (Vc), by using transganglionic transport of wheat germ agglutinin conjugated to horseradish peroxidase (WGA-HRP). A total of 93 labeled boutons were serially sectioned, in which some sections were incubated with gamma-aminobutyric acid (GABA) antiserum. Almost all labeled boutons formed asymmetric contact with nonprimary dendrites, in which more than half of labeled boutons in the Vc made synapses with their spines. The labeled boutons could be divided into two types on the basis of numbers of dense-cored vesicles (DCVs) in a boutons: S-type and DCV-type. Almost all labeled boutons in the Vp and Vdm were S-type, whereas two types were distributed evenly in the Vc. In contrast to DCV-type boutons, the S-type was frequently postsynaptic to unlabeled axon terminals containing a mixture of round, oval, and flattened vesicles (p-endings) and forming symmetrical synapses. Most p-endings examined were immunoreactive to GABA. The frequency of axoaxonic contacts was higher for labeled boutons in the Vp than in the Vdm and Vc. These results suggest that the three structures of trigeminal sensory nuclei serve distinct functions in nociceptive processing.

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Section: Indexing Terms: Ultrastructure; Synapse; Immunogold; Nocicepmentioning

confidence: 99%

Section: Synaptic Organization Of Tooth Pulp Afferent Terminals In Trmentioning

confidence: 99%

Synaptic organization of tooth pulp afferent terminals in the rat trigeminal sensory nuclei

Bae

Kim

Choi

et al. 2003

J of Comparative Neurology

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“…The cutaneous small-diameter afferents terminate extensively in the subnucleus caudalis and caudal interpolaris (Gobel et al, 1981;Hayashi, 1985;Jacquin et al, 1988), although there are some data suggesting that some might terminate further rostrally in the VBSNC (Falls, 1988;Sugimoto et al, 1997b; and see Section V). Moreover, primary afferents from the tooth pulp, which is primarily innervated by small-diameter afferents (see Sessle, 1987;Narhi et al, 1994), have been reported in both electrophysiological and anatomical investigations to terminate in great numbers in rostral as well as caudal components of the VBSNC (Tsuru et al, 1989;Hu et al, 1992b;Takemura et al, 1993;Barnett et al, 1995;and see Sessle, 1987).…”

Section: Trigeminal Brainstem Sensory Nuclear Complexmentioning

confidence: 99%

Acute and Chronic Craniofacial Pain: Brainstem Mechanisms of Nociceptive Transmission and Neuroplasticity, and Their Clinical Correlates

Sessle

2000

Critical Reviews in Oral Biology & Medicine

610

541

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This paper reviews the recent advances in knowledge of brainstem mechanisms related to craniofacial pain. It also draws attention to their clinical implications, and concludes with a brief overview and suggestions for future research directions. It first describes the general organizational features of the trigeminal brainstem sensory nuclear complex (VBSNC), including its input and output properties and intrinsic characteristics that are commensurate with its strategic role as the major brainstem relay of many types of somatosensory information derived from the face and mouth. The VBSNC plays a crucial role in craniofacial nociceptive transmission, as evidenced by clinical, behavioral, morphological, and electrophysiological data that have been especially derived from studies of the relay of cutaneous nociceptive afferent inputs through the subnucleus caudalis of the VBSNC. The recent literature, however, indicates that some fundamental differences exist in the processing of cutaneous vs. other craniofacial nociceptive inputs to the VBSNC, and that rostral components of the VBSNC may also play important roles in some of these processes. Modulatory mechanisms are also highlighted, including the neurochemical substrate by which nociceptive transmission in the VBSNC can be modulated. In addition, the long-term consequences of peripheral injury and inflammation and, in particular, the neuroplastic changes that can be induced in the VBSNC are emphasized in view of the likely role that central sensitization, as well as peripheral sensitization, can play in acute and chronic pain. The recent findings also provide new insights into craniofacial pain behavior and are particularly relevant to many approaches currently in use for the management of pain and to the development of new diagnostic and therapeutic procedures aimed at manipulating peripheral inputs and central processes underlying nociceptive transmission and its control within the VBSNC.

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“…If it is external, cold and hypertonic solutions will probably cause discomfort or pain. If it is internal, usually only occlusal contact will cause pain, even in the absence of prematurities [48].…”

Section: Sealing Of the Luting-tooth Interface And Hypersensitivitymentioning

confidence: 99%

Conventional and adhesive luting cements

Macorra

Pradíes

2002

Clinical Oral Investigations

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Luting materials for fixed prosthesis must fulfill special requirements in order to retain indirect restorations and fully maintain the integrity of abutments. The main requirements (inhibition of plaque accumulation, sealing of interface, possible antibacterial effects, acceptable solubility, wear, mechanical properties, adhesion, radiopacity, film thickness, type of curing, esthetics, storage, and cost) are reviewed to update clinical criteria on the selection of suitable materials. It can be concluded that there is no ideal luting material on the market. Alleged improvements in the physical data of newer materials do not necessarily result in better clinical performance. Only clinical trials can confirm the assumed benefits of materials.

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The neurophysiological basis and the role of inflammatory reactions in dentine hypersensitivity

Cited by 68 publications

References 51 publications

Synaptic organization of tooth pulp afferent terminals in the rat trigeminal sensory nuclei

Synaptic organization of tooth pulp afferent terminals in the rat trigeminal sensory nuclei

Acute and Chronic Craniofacial Pain: Brainstem Mechanisms of Nociceptive Transmission and Neuroplasticity, and Their Clinical Correlates

Conventional and adhesive luting cements

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