The neuropathies associated with diabetes mellitus

Mulder, Donald W.; Lambert, Edward H.; Bastron, James A.; Sprague, Randall G.

doi:10.1212/wnl.11.4.275

Cited by 223 publications

(79 citation statements)

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“…It results in pain, paresthesiae, and sensory loss in the lateral aspect of the thigh (31) and can lead to significant disability when the diagnosis is missed. Obesity and diabetes are the most common causes, followed by trauma due to external injury of the nerve as it runs down the lateral aspect ofthethigh.Mostwillresolvespontaneously and are therefore conservatively managed, using focal nerve block at the inguinal ligament, with a combination of lidocaine and corticosteroids as well as rest, and reduction or elimination of aggravating factors.…”

Section: Lateral Femoral Cutaneous Nervementioning

confidence: 99%

Focal Entrapment Neuropathies in Diabetes

et al. 2004

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Section: Lateral Femoral Cutaneous Nervementioning

confidence: 99%

Focal Entrapment Neuropathies in Diabetes

et al. 2004

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“…Data on sensory nerve CV in experimental models of diabetes include reduced sensory nerve CV in the dorsal spinal root [1], saphenous nerve [2], tibial nerve [5], sural and tibial nerves [6]. No detailed data on cutaneous nerve conduction velocity in experimental diabetes is available.It is also now generally agreed that peripheral nerve conduction abnormalities occur in diabetic peripheral neuropathy in man [7][8][9][10][11][12]. It is interesting that sensory nerves respond rather differently to treatment compared with motor nerves.…”

mentioning

confidence: 99%

“…It is also now generally agreed that peripheral nerve conduction abnormalities occur in diabetic peripheral neuropathy in man [7][8][9][10][11][12]. It is interesting that sensory nerves respond rather differently to treatment compared with motor nerves.…”

mentioning

confidence: 99%

The correlation between sensory nerve conduction velocities and three metabolic indices in rats treated with streptozotocin

Julu

1988

Diabetologia

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Summary.The fastest conduction velocities of the myelinated (A) and unmyelinated (C) sensory nerve fibres were measured in the saphenous nerves of rats made diabetic up to 5 weeks previously by injection of streptozotocin. The conduction velocity of the fastest A-alpha fibres in treated rats fell by 25% compared to control rats. The effect on the slow A-delta fibres was small but C-fibres were not affected. Levels of glycosylated haemoglobin, random plasma glucose, and the net changes in body weights were also measured. There were significant changes in these three metabolic indices among diabetic rats (t7 <0.001) and the three indices were inter-related. There was a good correlation between A-fibre conduction velocity and levels of glycosylated haemoglobin but no significant relationship between C-fibre conduction velocity and this metabolic index. A-fibre conduction velocity was statistically more correlated with levels of glycosylated haemoglobin than the other two metabolic indices (p < 0.01).Key words: Diabetes, streptozotocin, A-fibres, C-fibres, conduction velocity, glycosylated haemoglobin, random plasma glucose, body weight.It is now well established that peripheral nerve conduction velocity (CV) is slowed in experimental diabetes mellitus [1][2][3][4]. Of the various animal models used, motor nerve CV has been studied most. Data on sensory nerve CV in experimental models of diabetes include reduced sensory nerve CV in the dorsal spinal root [1], saphenous nerve [2], tibial nerve [5], sural and tibial nerves [6]. No detailed data on cutaneous nerve conduction velocity in experimental diabetes is available.It is also now generally agreed that peripheral nerve conduction abnormalities occur in diabetic peripheral neuropathy in man [7][8][9][10][11][12]. It is interesting that sensory nerves respond rather differently to treatment compared with motor nerves. For example, vibratory threshold did not improve with short-term insulin therapy and yet motor nerve CV increased [13]; sensory action potential showed no improvement with insulin treatment while motor nerve CV increased [14]; sensory nerve CV did not improve with diet treatment in Type 2 (non-insulin-dependent) diabetic patients but motor nerve CV improved and correlated well with fasting plasma glucose concentrations [15]. Improvement in both sensory nerve CV and sensory action potential only began after intensive insulin treatment for a long period [16]. This unique response of sensory nerves to the treatment of diabetes, and the fact that the symptoms of diabetic neuropathy are mainly sensory [17], calls for a more detailed study of the sensory nerves especially in experimental models of diabetes where the different classes of fibres can be sampled easily.This study was undertaken to provide some more data on cutaneous nerve CVs in streptozotocin-diabetes and to correlate these with three metabolic indices in order to throw light on the possible mechanism(s) leading to conduction abnormalities. Materials and methods Experimental animalsThirty femal...

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“…Five studies [2][3][4][5][6] show different changes in the neurophysiological parameters in diabetes mellitus. In diabetic nerve, conduction velocity of the action potential is decreased, the amplitude of action potentials, both sensory and motor, is smaller, and the latency time is elongated.…”

Section: Pathophysiological Changes Of Diabetes Mellitus That Can Intmentioning

confidence: 99%

Diabetes Mellitus and Neuromuscular Blockade: Review

Ignacio¹,

Felix²

2016

J Diabetes Metab

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Introduction and objectives: International Diabetes Federation (IDF) estimates that worldwide there are 415 million adults aged 20-79 with diabetes mellitus (DM). Although diabetes mellitus (DM) is a highly prevalent disease, only a handful of studies have examined the neuromuscular function in diabetic patients. Even more surprising is this data, if we think that neuromuscular blockade (NMB) is an essential part in the induction and maintenance of general anesthesia. NMB is induced by neuromuscular blocking agents (NMBA). The aim of this review is to update the knowledge of neuromuscular blockade in diabetes mellitus and its implications in clinical practice.

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The neuropathies associated with diabetes mellitus

Cited by 223 publications

References 0 publications

Focal Entrapment Neuropathies in Diabetes

Focal Entrapment Neuropathies in Diabetes

The correlation between sensory nerve conduction velocities and three metabolic indices in rats treated with streptozotocin

Diabetes Mellitus and Neuromuscular Blockade: Review

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