The neuronal organization of cerebellar lobe C1 in the mormyrid fish gnathonemus petersii (teleostei)

Nieuwenhuys, Rudolf; Pouwels, Erika; Smulders-Kersten, E.

doi:10.1007/bf00522813

Cited by 54 publications

(33 citation statements)

References 11 publications

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“…Our results confirm and extend the morphological descriptions of previous studies of cellular elements in the central lobes of the mormyrid cerebellum that were based mainly on the Golgi technique (Meek and Nieuwenhuys, 1991;Nieuwenhuys and Nicholson, 1969b;Nieuwenhuys et al, 1974). To provide a coherent picture of the different cellular elements, the presentation of our results includes a relatively complete description of the different cellular elements, including features that have already been described in previous studies.…”

Section: Resultssupporting

confidence: 91%

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Cell morphology and circuitry in the central lobes of the mormyrid cerebellum

Han

Meek

Campbell

et al. 2006

J of Comparative Neurology

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The cerebellum of mormyrid electric fish is large and unusually regular in its histological structure. We have examined the morphology of cellular elements in the central lobes of the mormyrid cerebellum. We have used intracellular injection of biocytin to determine the morphology of cells with somas in the cortex, and we have used extracellular placement of anterograde tracers in the inferior olive to label climbing fibers. Our results confirm previous Golgi studies and extend them by providing a more complete description of axonal trajectories. Most Purkinje cells in mormyrids and other actinopterygian fishes are interneurons that terminate locally in the cortex on efferent neurons that are equivalent to cerebellar nucleus cells in mammals. We confirm the markedly sagittal distribution of the fan-like dendrites of Purkinje cells, efferent cells, and molecular layer interneurons. We show that Purkinje cell axons extend further than was previously thought in the sagittal plane. We show that climbing fibers are distributed in narrow sagittal strips and that these fibers terminate exclusively in the ganglionic layer below the molecular layer where parallel fibers terminate. Our results together with those of others show that the central lobes of the mormyrid cerebellum, similar to the mammalian cerebellum, are composed of sagittally oriented modules made up of Purkinje cells, climbing fibers, molecular layer interneurons, and cerebellar efferent cells (cerebellar nucleus cells in mammals) that Purkinje cells inhibit. This modular organization is more apparent and more sharply defined in the mormyrid than in the mammal.

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Section: Resultssupporting

confidence: 91%

“…1; Meek, 1992;Nieuwenhuys and Nicholson, 1969a, b;Nieuwenhuys et al, 1974). The part known as the valvula in mormyrids is composed of a series of small ridges and covers the external surface of the brain, with the anterior portion being folded back on itself (Fig.…”

mentioning

confidence: 97%

Cell morphology and circuitry in the central lobes of the mormyrid cerebellum

Han

Meek

Campbell

et al. 2006

J of Comparative Neurology

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“…Figures 3 and 18). Indeed, the fusiform neurons of the teleost cerebellar molecular layer, described by other workers, appear similar to the cells that we have identified in our NSE preparations (Finger, 1983;Nieuwenhuys et al, 1974;Nieuwenhuys, 1967;Schnitzlein and Faucette, 1969;Larsell, 1967;Franz, 1911). However, definitively determining the identity of these cells will require either double-labeling protocols, which may be difficult because of the very weak GFAP signal, or EM histochemistry of NSE-reacted tissues (Ling et al, 1982;Akikusa et al, 1984).…”

Section: Discussionsupporting

confidence: 89%

Nonspecific esterase activity in astrocytes of the goldfish brain.

Pepperell¹,

Levine²

1996

J Histochem Cytochem.

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We examined the distribution of nonspecific esterase (NSE) activity in the brain of the goldfish, Carawius auracus, and found that the enzyme is expressed at high levels in cells that appeared to be radial astrocytes. Several instances in which neurons expressed NSE activity were also seen. To confirm the identity of the radial profiles as astrocgtes, similar sections were labeled with antiserum against goldfiih glial fibrillary acidic protein (GFAP). The concordance between the NSE and the anti-GFAP data in both the visual system and the telencephalon was essentially complete, confirming that the NSE reaction was labeling astrocytes in these structures. The two methods also gave similar results in both the cerebellum and the vagal lobes, although the concordance between them in these instances was somewhat less complete.

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“…2). These observations agree with the organization of CC reported by previous studies [Nieuwenhuys et al, 1974;Pouwels, 1978;Meek and Nieuwenhuys, 1991].…”

Section: Gross Morphology and Cytoarchitecture Of The CCsupporting

confidence: 82%

Afferent Connections of the Corpus cerebelli in Holocentrid Teleosts

Xue

Yamamoto²,

Yang³

et al. 2004

Brain Behav Evol

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The holocentrid corpus cerebelli (CC) is composed of the dorsal (CCd) and ventral (CCv) lobes. In the present study, afferent connections of the CCd and CCv in holocentrid teleosts (Sargocentron rubrum and S. diadema) were examined by means of tract-tracing methods. Tracer injections into either lobe of the CC labeled neurons in the ipsilateral area pretectalis pars anterior et posterior, nucleus paracommissuralis (NPC), nucleus accessorius opticus and nucleus tegmentocerebellaris. Labeled neurons were also present in the bilateral nucleus lateralis valvulae (NLV), nucleus raphes, nucleus reticularis lateralis and inferior reticular formation, and in the contralateral inferior olive. Injections into the CCd labeled only a few neurons in the area pretectalis pars anterior et posterior, nucleus accessorius opticus and nucleus tegmentocerebellaris, whereas many labeled cells were seen in these nuclei after CCv injections. Injections into the CCv also revealed afferent connections that were not observed after CCd injections. The CCv injections labeled additional neurons in the ipsilateral torus longitudinalis and nucleus subeminentialis and in the bilateral nucleus subvalvularis and nucleus of the commissure of Wallenberg. These differences in afferent connections suggest functional differences between the CCd and CCv. After injections into the CCd, labeled neurons in the NPC were restricted to a medial portion of the nucleus. On the other hand, after injections into the CCv, labeled neurons were found throughout the NPC. Labeled neurons in the NLV were mainly located in its rostral portion following CCd injections, whereas labeled neurons were mainly distributed in the medial portion following CCv injections. These observations suggest topographical organizations of the NPC-CC and NLV-CC projections.

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The neuronal organization of cerebellar lobe C1 in the mormyrid fish gnathonemus petersii (teleostei)

Cited by 54 publications

References 11 publications

Cell morphology and circuitry in the central lobes of the mormyrid cerebellum

Cell morphology and circuitry in the central lobes of the mormyrid cerebellum

Nonspecific esterase activity in astrocytes of the goldfish brain.

Afferent Connections of the Corpus cerebelli in Holocentrid Teleosts

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