The neuronal basis of copper induced modulation of anxiety state in rat

Abbaoui, Abdellatif; Hiba, Omar El; Gamrani, Halima

doi:10.1016/j.acthis.2016.10.003

Cited by 25 publications

(16 citation statements)

References 37 publications

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“…Similar observations were also made later by Narang et al [27]. Also, it was proven that antidepressant treatment significantly reduced [13]. As known, the loss of 5 HT innervation in the brain is one of the most recognized neuronal basics of anxiety and depression disorders [53].…”

Section: Discussionsupporting

confidence: 81%

“…An excess of this metal may be associated with DA dysregulation [59]. In the study of Przybyłkowski et al, an increase in Cu content in different brain regions and slight decrease in DA levels in the striatum was demonstrated [60], a DAergic structure involved in the control of anxiety and depression [13]. Rats show a reduction of DA and its metabolites contents in striatum with an inhibition of Tyrosine Hydroxylase mRNA expression in substantia nigra pars compacta [61].…”

Section: Discussionmentioning

confidence: 99%

“…As known, the loss of 5 HT innervation in the brain is one of the most recognized neuronal basics of anxiety and depression disorders [53]. It is reported that Cu can modulate the 5 HT biosynthesis [13]. Generally, The loss of monomeric 5-HT may help account for behaviour disturbances observed, but the central control of the animal behavior is very complex and involves several other neuronal systems, especially DA [13].…”

Section: Discussionmentioning

confidence: 99%

“…Generally, The loss of monomeric 5-HT may help account for behaviour disturbances observed, but the central control of the animal behavior is very complex and involves several other neuronal systems, especially DA [13]. The dopaminergic system seems to be another target of Cu poisoning [13]. An excess of this metal may be associated with DA dysregulation [59].…”

Section: Discussionmentioning

confidence: 99%

“…It is known that Cu can ensure the well-functioning of different biological systems including CNS [13], It has a crucial role in erythropoiesis, myelin formation, synthesis of hormones, antioxidant protection and immune system modulation [14]. Serving as a structural component and cofactor for many proteins and enzymes comprising the free radical scavenger superoxide dismutase (Cu, Zn-SOD), dopamine monooxygenase, cytochrome oxidase, lysyl oxidase and ceruloplasmin, Cu regulates a large number of bodily biochemical processes [15] [16].…”

Section: Introductionmentioning

confidence: 99%

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Affective Behavior Dysregulation Was Induced by Chronic Administration of Copper in Wistar Rats

Lamtai¹,

Ouakki²,

Zghari³

et al. 2019

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As both deficiency and excess of copper (Cu) can be harmful, dysregulation in its homeostasis has been connected with various neurological disorders. The present study was undertaken to examine whether Cu chronic administration can induce alterations of affective behavior especially anxiety and depression levels in male and female rats. Twenty-four rats, for each gender, divided in control and three test groups (n = 6), were injected intraperitoneally with saline (0.9% NaCl) or CuCl 2 (0.25 mg/kg, 0.5 mg/kg and 1 mg/kg) for 8 weeks. After treatment period, animals were tested in the open-field, elevated plus maze tests for anxiety-like behavior, and forced swimming test for depression-like behavior. Results demonstrated that Cu administered chronically, exerts an anxiogenic effect in rats. In the OFT, Cu decreases the TCA and NRC parameters without modifying the locomotor activity represented by the NTS parameter. With regard to EPM, Cu decreases TOA and EOA parameters without modifying the TAE parameter. A significant increase in depression-like symptoms was also exhibited by Cu treated rats (p < 0.001). A dose of 1 mg/kg CuCl 2 showed maximum anxiety-like and depression-like symptoms as compared to controls as well as from the other two doses indicating dose-dependent effects of chronic Cu administration. Overall, these results suggest that intoxication with Cu has potentially deleterious effects on brain as reflected in behavioral dysfunctions such as depression and anxiety.

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Section: Discussionsupporting

confidence: 81%