The Neurologic Complications of Hemophilia

Femoral nerve conduction in diabetes and chronic occlusive vascular disease.

“…At necropsy they discovered degenerative changes in the myelin sheaths, but no degeneration of anterior or posterior roots. Involvement of the femoral nerve in many other maladies has been described such as in haemophilia (Aggeler and Lucia, 1944;Lyons, 1953), in osteoarthritis of the hip joint (Moffie, 1953), and in abdominal surgery by pressure from retractors (Johnson and Montgomery, 1958). None of the patients in the present series had such damage.…”

Ischaemic Lesions of Peripheral Nerves: A Review

“…In haemophilia lesions of the peripheral nerves are uncommon, and when they do occur are usually due to the direct pressure of a haematoma; the nerve most frequently affected appears to be the femoral (Aggeler and Lucia, 1944). Occasionally when haemorrhage beneath 84 ISCHAEMIC LESIONS OF PERIPHERAL NERVES the deep fascia occurs in a limb, there may be serious interference with the circulation and ischaemic lesions of the peripheral nerves may result; this was the sequence of events in the case reported by Lord (1926) and in the two cases observed by Seddon and quoted by Parkes (1945).…”

Spinal epidural haematoma in a patient with haemophilia-B

“…1,2 The most common neurological complication of haemophilia is bleeding into the peripheral nerve compartments and the incidence is between 1.3 and 20.4%. 3,4 Bleeding into the central nervous system is seen in about 2.2 to 7.8% of cases. 5,6 Intracranial haemorrhage remains as the leading cause of death, and carries a mortality of about 30%.…”