The neuroinflammatory role of microglia in Alzheimer's disease and their associated therapeutic targets
Melika AmeliMojarad,
Mandana AmeliMojarad
Abstract:IntroductionAlzheimer's disease (AD), the main cause of dementia, is characterized by synaptic loss and neurodegeneration. Amyloid‐β (Aβ) accumulation, hyperphosphorylation of tau protein, and neurofibrillary tangles (NFTs) in the brain are considered to be the initiating factors of AD. However, this hypothesis falls short of explaining many aspects of AD pathogenesis. Recently, there has been mounting evidence that neuroinflammation plays a key role in the pathophysiology of AD and causes neurodegeneration by… Show more
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