The neurogenic contribution to synovial leucocyte infiltration and other outcome measures in a guinea pig model of arthritis

Hood, Vivienne C.; Cruwys, Simon; Urbán, László; Kidd, Bruce L.

doi:10.1016/s0304-3940(00)01790-0

Cited by 21 publications

(7 citation statements)

References 6 publications

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“…Although CIA differs from RA in being rapidly progressive, it is established as a useful model for preclinical testing of treatments for RA . Central neurological influences originating in the spinal cord have been implicated in the generation of inflammatory arthritis by experiments in which the development of arthritis is limited by prior joint denervation .…”

Section: Discussionmentioning

confidence: 99%

Dorsal Root Ganglion Field Stimulation Prevents Inflammation and Joint Damage in a Rat Model of Rheumatoid Arthritis

Pan

Zhang

Chao

et al. 2018

Neuromodulation: Technology at the Neural Interface

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Section: Discussionmentioning

confidence: 99%

Dorsal Root Ganglion Field Stimulation Prevents Inflammation and Joint Damage in a Rat Model of Rheumatoid Arthritis

Pan

Zhang

Chao

et al. 2018

Neuromodulation: Technology at the Neural Interface

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“…Primary-afferent activation leading to contralateral activation of homologous afferents has been suggested to take place in the symmetric spread of arthritis [32]. It is hypothesized that the contralateral phenomena in joint affections is an attempt to upregulate protective proinflammatory responses in the preparation for an insult which has already occurred [33]. In a recent study using a burn injury model affecting the hind paw of rats leading to allodynia, it was shown that the allodynia was spread to the contralateral limb, and in this case, microglial activation occurred on both the ipsilateral and contralateral sides of the spinal cord [34].…”

Section: Discussionmentioning

confidence: 99%

A new feature of importance for the TNF-alpha system in inflammation—Bilateral myositis that develops early in response to unilateral overuse shows a marked involvement of TNF-alpha not only in the exercised side but also contralaterally

Renström

Stål²,

Forsgren³

2013

MRI

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Using a rabbit model leading to myositis in response to exercise-induced muscle overuse, we have previously observed that TNF-alpha is involved in the exercised muscle in early developing myositis as well as both ipsi-and contralaterally in the myositis which develops in response to a lengthened period of overuse. It is unknown if TNF-alpha can also be engaged contralaterally in early stages of myositis. The hypothesis was that this is the case. It was therefore evaluated whether the TNF-alpha system is early involved contralaterally. An experimental model of 1 week of overuse of the soleus muscle on one side leading to myositis was used, and in situ hybridization and immunohistochemistry were applied to study the expression patterns of TNF-alpha in the soleus muscle in the contralateral side. TNF-alpha was expressed in the myositis process which occurred contralaterally. There were thus TNF-alpha mRNA reactions in the cells of the inflammatory infiltrates, in blood vessel walls and in certain of the muscle fibers. Parts of the latter were necrotic fibers, whereas others were interpreted to be in a regenerative stage. TNF-alpha immunoreactions were seen for infiltrating white blood cells. The observations show that the TNF-alpha system is early involved in the cross-over effects that occur in response to unilateral muscle overuse leading to myositis bilaterally. TNF-alpha is likely to have pro-inflammatory and destructive effects but also to have effects in the muscle regenerative processes. The occurrence of an early involvement of the TNF-alpha system contralaterally to the injury side shows a new aspect of importance of this system in inflammation.

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“…7 However, systemic administration of capsaicin does not selectively target articular nerves, and anti-inflammatory and other toxic effects may be mediated by the action of capsaicin at non-articular sites. As the development of PsA had been prevented in our patient by sensory denervation we proceeded to test this hypothesis by investigating the effect of localised surgical selective sensory denervation of the knee in an animal model of acute inflammatory arthritis.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of sensory denervation in inflammatory arthritis (evidence of regulatory neuroimmune pathways in the arthritic joint)

Kane

Lockhart²,

Bálint

et al. 2005

Annals of the Rheumatic Diseases

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Objective: To investigate the direct effect of joint innervation on immune mediated joint inflammation in a patient with psoriatic arthritis (PsA). Case report: The patient developed arthritis mutilans in all digits of both hands with the exception of the left 4th finger, which had prior sensory denervation following traumatic nerve dissection. Plain radiography, ultrasonography and nerve conduction studies of the hands confirmed the absence of articular disease and sensory innervation in the left 4th digit. Methods: This relationship between joint innervation and joint inflammation was investigated experimentally by prior surgical sensory denervation of the medial aspect of the knee in six Wistar rats in which carrageenan induced arthritis was subsequently induced. Prior sensory denervation-with preservation of muscle function-prevented the development of inflammatory arthritis in the denervated knee. Discussion: Observations in human and animal inflammatory arthritis suggest that regulatory neuroimmune pathways in the joint are an important mechanism that modulates the clinical expression of inflammatory arthritis.A 60 year old woman presented with psoriasis, which she had had since age 16, and psoriatic arthritis (PsA) since age 45. Initial involvement of the right hand had progressed to an inflammatory polyarthritis, affecting the small joints of both hands and both knees, and to dactylitis of the toes but without spondylitis or sacroiliitis. Current drug treatment comprised methotrexate and rofecoxib and there were no signs of active synovitis of the hands, either upon clinical examination or by laser Doppler imaging. 1 On examination the patient was noted to have established arthritis mutilans of the metacarpophalangeal (MCP), proximal interphalangeal (PIP), and distal interphalangeal (DIP) joints of the hands with complete sparing of the left 4th digit ( fig 1A). Of note the left palm had been lacerated as a child-before the onset of skin or joint disease-with consequent nerve injury and loss of sensation in the left 4th finger. The left 4th digit was noted to be hypoplastic with a normal range of active and passive movement but with loss of soft touch, pinprick, and vibration sensation along the entire digit distal to the laceration. Investigations were consistent with inactive PsA (rheumatoid factor negative, C reactive protein ,6 mg/l, erythrocyte sedimentation rate 1 mm/1st h).Plain radiography of the hand confirmed a symmetrical destructive arthropathy of the MCP, PIP, and DIP joints with features of bony resorption and periosteal proliferation in all digits, but with sparing of the small joints of the left 4th digit ( fig 1B). Ultrasonography-a more sensitive measure of joint inflammation and damage-of PIP joints in the right and left 4th digits demonstrated proliferative changes in the right 4th digit but not in the left 4th digit ( fig 1C). Nerve conduction studies confirmed the complete absence of sensory innervation in the left 4th digit. On stimulation of the 4th digit no reproducible sensory r...

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The neurogenic contribution to synovial leucocyte infiltration and other outcome measures in a guinea pig model of arthritis

Cited by 21 publications

References 6 publications

Dorsal Root Ganglion Field Stimulation Prevents Inflammation and Joint Damage in a Rat Model of Rheumatoid Arthritis

Dorsal Root Ganglion Field Stimulation Prevents Inflammation and Joint Damage in a Rat Model of Rheumatoid Arthritis

A new feature of importance for the TNF-alpha system in inflammation—Bilateral myositis that develops early in response to unilateral overuse shows a marked involvement of TNF-alpha not only in the exercised side but also contralaterally

Protective effect of sensory denervation in inflammatory arthritis (evidence of regulatory neuroimmune pathways in the arthritic joint)

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